CD13 Autoantibodies Are Elevated in Sera From Mothers of Infants With Neonatal Cholestasis of Different Causes

Xu, Xinling; Rahbar, Afsar; Omarsdottir, Soley; Teng, Jonas; Németh, Antal; Fischler, Björn; Söderberg‐Nauclér, Cecilia

doi:10.1097/mpg.0000000000001266

Cited by 6 publications

(5 citation statements)

References 30 publications

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“…Jaundice was temporarily improved with ganciclovir. Previous reports showed that CMV is associated with hepatitis and BA ( 12 , 13 ). These suggested that not only CPHD but also CMV might have contributed to cholestasis in our case.…”

Section: Discussionmentioning

confidence: 92%

A case of an infant with congenital combined pituitary hormone deficiency and normalized liver histology of infantile cholestasis after hormone replacement therapy

Wada

Kobayashi

Moriyama

et al. 2017

Clin Pediatr Endocrinol

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Abstract. Congenital combined pituitary hormone deficiency (CPHD) may present with cholestasis in the neonate or during early infancy. However, its precise mechanism is unknown. A 3-mo-old boy presented with cryptorchidism and hypoplastic scrotum after birth. Neonatal jaundice was noted but temporarily improved with phototherapy. Jaundice recurred at 2 mo of age. Elevated direct bilirubin (D-Bil) and liver dysfunction were found but cholangiography showed no signs of biliary atresia (BA). Liver biopsy findings showed giant cell formation of hepatocytes with hypoplastic bile ducts. Subsequent magnetic resonance imaging (MRI) of the head revealed a hypoplastic pituitary gland with an ectopic posterior lobe, and the patient was diagnosed with congenital CPHD based on decreased secretion of cortisol and GH by the pituitary anterior lobe load test. D-Bil levels promptly improved after hydrocortisone (HDC) replacement. We subsequently began replacement with levothyroxine (L-T 4 ) and GH, and liver histology showed normal interlobular bile ducts at 8 mo old. This is the first case report of proven histological improvement after hormone replacement therapy. This suggested that pituitary-mediated hormones, especially cortisol, might be involved in the development of the bile ducts.

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Section: Discussionmentioning

confidence: 92%

A case of an infant with congenital combined pituitary hormone deficiency and normalized liver histology of infantile cholestasis after hormone replacement therapy

Wada

Kobayashi

Moriyama

et al. 2017

Clin Pediatr Endocrinol

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“…However, careful attention to the patient’s history can be informative. For example, Wetzler et al recently described a case report of an adolescent that described an inability to drink from a water fountain without coughing, due to his H-type fistula [ 11 ]. Our patient described the ability to reflux quantities of food and liquid on command.…”

Section: Discussionmentioning

confidence: 99%

Adolescent With VACTERL Association Presents With Recurrent Pneumonia

Stack

Westmoreland

2020

Cureus

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VACTERL is a condition that includes various anatomic anomalies including vertebral, cardiac, tracheoesophageal fistula (TEF), renal, and limb defects. TEF can be found in up to 80% of patients with the condition. Although TEFs are usually identified early in life, the H-type TEF can be more difficult to detect. We report the case of a 15-year-old male with a previous diagnosis of VACTERL who presented with a history of recurrent pneumonia, chest pain, and asthma and was found to have a previously undetected H-type TEF that was surgically repaired. When evaluating a patient with features of VACTERL, it is important to choose studies that can explore the presence of all associated features. Clinical history and type of imaging utilized can be essential in making a timely diagnosis, especially for H-type TEF.

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“…[5][6][7][8][9] Based on Xu et al, 2017 study found that CD13-specific autoantibodies, known to be induced by HCMV infection, that exist in mothers of infant cholestasis but not in mothers of healthy infants. 10 The incidence of cholestasis increases in infants with less gestational age and low birth weight babies, because it is associated with impaired liver function. Other risk factors associated with cholestasis are babies who experience recurrent sepsis and parenteral nutrition.…”

Section: Introductionmentioning

confidence: 99%

Correlation between Maternal Infection and Infant Cholestasis

Mulia

Ranuh

Ernawati

2021

Universitas Airlangga

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Introduction: Infant cholestasis has been associated to viral infection. Cytomegalovirus in the pathogenesis of neonatal hepatitis has been already known and it is one of the possible etiological of biliary atresia. The aim of this study was to outline the correlation between maternal infection and infant cholestasis (aged 0-1 year old) in Department of Pediatrics Dr. Soetomo General Hospital, Surabaya. Methods: A case-control study of pregnant women who gave birth in Dr. Soetomo General Hospital from June 2016 to June 2017. The data were taken from medical records. The cases were defined as pregnant women with babies who had cholestasis, and the control was pregnant women who gave birth to a baby without cholestasis within the age of 0-1 year old. Sample cases in this study were drawn from the total population, with the inclusion criteria babies who had cholestasis, and exclusion criteria that include complications of pregnancy and a history of infant’s parent with genetic disorders. The control variable studied was maternal infection history and sex. Samples were taken by purposive control. The data were obtained then summarized and analyzed by univariate and bivariate, using the chi-square table analysis. Results: The number of cases that met the inclusion criteria were 68 patients, and the amount of control taken was 110 patients. The total number of patients studied was 178 patients. Univariate analysis found the cholestasis was more common in mother with infection during pregnancy (73.53% from the total of cholestasis). Bivariate analyzes found relationship between pregnancy infection and cholestasis (p = <0.001, or = 20.726). Conclusion:The maternal infection is significantly associated with cholestasis in infants.

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CD13 Autoantibodies Are Elevated in Sera From Mothers of Infants With Neonatal Cholestasis of Different Causes

Cited by 6 publications

References 30 publications

A case of an infant with congenital combined pituitary hormone deficiency and normalized liver histology of infantile cholestasis after hormone replacement therapy

A case of an infant with congenital combined pituitary hormone deficiency and normalized liver histology of infantile cholestasis after hormone replacement therapy

Adolescent With VACTERL Association Presents With Recurrent Pneumonia

Correlation between Maternal Infection and Infant Cholestasis

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