CD10 Immunostaining distinguishes atypical polypoid adenomyofibroma (atypical polypoid adenomyoma) from endometrial carcinoma invading the myometrium

Ohishi, Yoshihiro; Kaku, Tsunehisa; Kobayashi, Hiroaki; Aishima, Shinichi; Umekita, Yoshihisa; Wake, Norio; Tsuneyoshi, Masazumi

doi:10.1016/j.humpath.2008.02.006

Cited by 37 publications

(15 citation statements)

References 23 publications

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“…The spindle cells within APAM are considered to be fibromuscular stromal cells, which show positive immunoreactivity for α‐SMA . The immunocytochemical analysis in the present study clearly demonstrated that fascicles of the spindle cells around the crowded endometrial glands are positive for α‐SMA, therefore, these spindle cells are considered to be fibromuscular stromal cells.…”

Section: Discussionsupporting

confidence: 61%

Cytomorphological features of atypical polypoid adenomyoma of the endometrium

et al. 2019

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Section: Discussionsupporting

confidence: 61%

Cytomorphological features of atypical polypoid adenomyoma of the endometrium

et al. 2019

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“…Ohishi et al . recently described the differences in the CD10 immunoreactivity or immunostaining pattern between the stromal components of APA and myoinvasive endometrial carcinoma 11 . This approach may be of great value in the future.…”

Section: Discussionmentioning

confidence: 96%

“…10 Ohishi et al recently described the differences in the CD10 immunoreactivity or immunostaining pattern between the stromal components of APA and myoinvasive endometrial carcinoma. 11 This approach may be of great value in the future. In conclusion, if endometrial hyperplasia is detected in a patient with APA, a strict follow-up examination by performing endometrial biopsy is mandatory.…”

Section: Discussionmentioning

confidence: 99%

Case of atypical polypoid adenomyoma that possibly underwent a serial progression from endometrial hyperplasia to carcinoma

Fukuda¹,

Sakurai²,

Yamamoto³

et al. 2011

J of Obstet and Gynaecol

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Atypical polypoid adenomyoma is a rare uterine tumor composed of atypical endometrial glands, which often exhibit squamous metaplasia, and a cellular smooth muscle stroma. Although atypical polypoid adenomyoma is categorized as a benign lesion, it is reportedly associated with endometrial cancer, and it shows persistence and recurrence even after conservative medical treatment. We present a rare case of atypical polypoid adenomyoma that possibly underwent a serial pathological change from endometrial hyperplasia to carcinoma in a 40-year-old woman with no history of pregnancy. She was diagnosed with atypical polypoid adenomyoma during polypectomy surgery. After resecting the atypical polypoid adenomyoma, endometrial hyperplasia complex was detected. This condition eventually progressed from atypical hyperplasia complex to endometrial adenocarcinoma, and total abdominal hysterectomy was performed. A patient with atypical polypoid adenomyoma who wishes to preserve her fertility should be carefully monitored for endometrial carcinoma. If endometrial hyperplasia is detected in such a patient, a meticulous follow-up examination by performing endometrial biopsy is mandatory.

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“…It has been suggested that CD10 may be helpful as it is absent in the stromal component of APA, while the myoinvasive glands of endometrioid adenocarcinoma are typically surrounded by a thin rim of CD10 positive stromal cells ('fringe-like' staining pattern). 65 h-caldesmon can be of use as it is strongly expressed in myometrial smooth muscle invaded by endometrioid adenocarcinoma while the myomatous or fibromyomatous stroma of APA is usually negative. 66 Less commonly, the differential diagnosis includes an endometrial polyp with variable amounts of smooth muscle (adenomyomatous polyp) or an endometrioid-type adenomyoma.…”

Section: Adenomyomasmentioning

confidence: 99%

A practical approach to the diagnosis of mixed epithelial and mesenchymal tumours of the uterus

McCluggage

2016

Modern Pathology

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The current 2014 World Health Organization (WHO) Classification of mixed epithelial and mesenchymal tumours of the uterus includes categories of carcinosarcoma, adenosarcoma, adenofibroma, adenomyoma and atypical polypoid adenomyoma, the last two lesions being composed of an admixture of benign epithelial and mesenchymal elements with a prominent smooth muscle component. In this review, each of these categories of uterine neoplasm is covered with an emphasis on practical tips for the surgical pathologist and new developments. In particular, helpful clues in the distinction between carcinosarcoma and dedifferentiated endometrial carcinoma will be discussed. In addition, salient features to help distinguish between adenofibroma, adenosarcoma, embryonal rhabdomyosarcoma and other mesenchymal neoplasms in the differential diagnosis will be outlined. Finally, a discussion of adenomyoma and its main differential diagnostic considerations will be covered.

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CD10 Immunostaining distinguishes atypical polypoid adenomyofibroma (atypical polypoid adenomyoma) from endometrial carcinoma invading the myometrium

Cited by 37 publications

References 23 publications

Cytomorphological features of atypical polypoid adenomyoma of the endometrium

Cytomorphological features of atypical polypoid adenomyoma of the endometrium

Case of atypical polypoid adenomyoma that possibly underwent a serial progression from endometrial hyperplasia to carcinoma

A practical approach to the diagnosis of mixed epithelial and mesenchymal tumours of the uterus

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