Cytomorphological features of atypical polypoid adenomyoma of the endometrium

Abstract

This study highlights the cytomorphological features of atypical polypoid adenomyoma (APAM). Squamous morules and/or short fascicles of spindle cells were found in five of the six cases. A combination of cytomorphological features can lead to a suspicion of APAM and avoid an overdiagnosis as endometrioid carcinoma.

Lesion‐targeted cytology to improve cytological sampling for atypical polypoid adenomyomas of the uterus: A case series and review of the literature

“…We reviewed 27 cases of APAs with cytological findings reported in the English literature (Table 2). 8‐11,13‐26 Seven of those cases involved neither atypical glandular cells nor spindle cells of APAs, similar to Cases 1 and 2. This suggests that cytological sampling of APAs is more difficult than expected.…”

“…In contrast, routine cytology of specimens in Cases 1-5 did not reveal spindle cells (Table 1) We reviewed 27 cases of APAs with cytological findings reported in the English literature (Table 2). [8][9][10][11][13][14][15][16][17][18][19][20][21][22][23][24][25][26] Our data suggest that the LTC method is an appropriate approach to increase the diagnostic accuracy of APAs.…”

“…As the histology suggests, to obtain accurate cytological and histological diagnoses of APAs, it is crucial to identify the presence of mesenchymal components without atypia, in addition to atypical glandular components. To date, there have been only a few reports of APAs diagnosed cytologically in the English literature 8‐11 …”

“…To date, there have been only a few reports of APAs diagnosed cytologically in the English literature. [8][9][10][11] Although the utility of cytology for various lesions in the cervix and endometrium is widely known, little attention has been paid to the utility of cytology in the diagnosis of APAs. In addition, no studies have examined cytological sampling methods to improve the cytological diagnosis of APAs.…”

Small‐cell neuroendocrine carcinoma in directly sampled endometrial cytology: A monocentric retrospective study of six cases

“…In recent years, reports have demonstrated the utility of endometrial cytological examination, particularly liquid‐based cytology, in the diagnosis of endometrial carcinoma and various types of benign and reactive conditions . However, studies on the cytological features of endometrial small‐cell NEC are scarce, and the utility of endometrial cytology has not been elucidated.…”