CD molecules 2006 — Human cell differentiation molecules

Zola, Heddy; Swart, Bernadette; Banham, Alison H.; Barry, Simon C.; Beare, A. S.; Bensussan, Armand; Boumsell, Laurence; Buckley, Chris; Bühring, Hans Jörg; Clark, Georgina J.; Engel, Pablo; Fox, David A.; Jin, Bo; Macardle, Peter J.; Malavasi, Fabio; Mason, David Y.; Stockinger, Hannes; Yang, Xifeng

doi:10.1016/j.jim.2006.11.001

Cited by 126 publications

(72 citation statements)

References 12 publications

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“…This expansion was reinforced with a name change; they are now the HCDM (Human Cell Differentiation Molecules) (Zola et al, 2007) Unfortunately there is not the same sort of all-inclusive drive toward a comprehensive characterization and evaluation of antibodies against tissue-bound cells. We feel that a comparable initiative directed towards solid organs, using the strategies and techniques described in this document, would yield many additional tools and reagents for the study of normal and pathological tissues.…”

Section: Resultsmentioning

confidence: 99%

Flow Cytometric Sorting of Cells from Solid Tissue – Reagent Development and Application

Canaday¹,

Dorrell²

2012

Flow Cytometry - Recent Perspectives

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Section: Resultsmentioning

confidence: 99%

Flow Cytometric Sorting of Cells from Solid Tissue – Reagent Development and Application

Canaday¹,

Dorrell²

2012

Flow Cytometry - Recent Perspectives

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“…From 2004, the Human Leukocyte Differ entiation Antigens Workshop was followed by a series of Human Cell Differentiation Molecules Workshops in order to assign a CD nomencla ture to nonleukocytespecific antibodies and cellular markers as well [50]. To date, approxi mately 500 CD markers have been identified, but a full classification is still missing [51,52].…”

Section: Role Of CD Markers In Diagnosticsmentioning

confidence: 99%

Cell Surface Membrane Proteins as Personalized Biomarkers: Where we Stand and Where we are Headed

et al. 2013

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Personalized medicine requires the development of a wide array of biomarker diagnostic assays, reflecting individual variations and thus allowing tailored therapeutic interventions. Membrane proteins comprise approximately 30% of total human proteins; they play a key role in various physiological functions and pathological conditions, although, currently, only a limited number of membrane proteins are applied as biomarkers. In many normal tissues, cell surface membrane proteins are not easily accessible for diagnostic sampling, and tumor-derived membrane preparations – while serving as potential tumor biomarkers – may not reflect physiological protein expression. In addition to post-translational modifications, which may include glycosylation, phosphorylation and lipid modifications, the trafficking of membrane proteins is also regulated. Moreover, a tight cellular quality control monitors membrane protein maturation, and continuous removal and reinsertion, involving special signaling systems, occurs in many cases. However, cell surface membrane proteins already serve as valuable prognostic and predicative biomarkers, for example, in hematological and immunological diseases, by the determination of the cluster of differentiation markers. In this review, we demonstrate the relevance of cell surface membrane biomarkers in various diseases and call attention to the potential application of red blood cell (erythrocyte) membrane proteins in this regard. Surprisingly, red blood cells express hundreds of membrane proteins, which seem to reflect a general genetic and regulatory background, and may serve as relatively stable and easily accessible personalized membrane biomarkers. Quantitative membrane protein detection in red blood cells by flow cytometry may bring a breakthrough in this regard.

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“…Use of more than one marker can make the cell selection very specific. However, not all cell types have a known specific surface marker [27].…”

Section: Challenges In Cell Sortingmentioning

confidence: 99%

Use of Microfluidic Technology for Cell Separation

Mohamed¹

2012

Blood Cell - An Overview of Studies in Hematology

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CD molecules 2006 — Human cell differentiation molecules

Cited by 126 publications

References 12 publications

Flow Cytometric Sorting of Cells from Solid Tissue – Reagent Development and Application

Flow Cytometric Sorting of Cells from Solid Tissue – Reagent Development and Application

Cell Surface Membrane Proteins as Personalized Biomarkers: Where we Stand and Where we are Headed

Use of Microfluidic Technology for Cell Separation

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