CCR5 promoter polymorphisms and HIV-1 perinatal transmission in Brazilian children

Souza, Paulo Roberto Eleutério de; Arraes, Luiz Cláudio; Filho, José Luiz de Lima; Bruneska, Danyelly; Milanese, Michele; Crovella, Sérgio

doi:10.1016/j.jri.2005.09.001

Cited by 14 publications

(10 citation statements)

References 18 publications

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“…[1][2][3] Genetic variations in certain chemokines and their receptors have been reported to be responsible for resistance to HIV-1 infection, delayed progression to AIDS, response to the treatment, and mother-to-child transmission. 4 Chemokine receptors are proteins found on the cell surface. 5 The entry of HIV-1 virus to the host cells is primarily mediated by the CD4 receptor and at least one coreceptor from multi-CC and CXC chemokine receptors.…”

Section: Introductionmentioning

confidence: 99%

Distribution OfCCR-5Δ32,CCR2-64I, andSDF-1-3′AAlleles Among Jordanians

Khabour

Abu-Haweleh²,

Alzoubi³

2013

AIDS Research and Human Retroviruses

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Entry of HIV virus into cells is mediated by chemokine receptors. Genetic variations in chemokine receptors have been shown to modulate susceptibility to HIV infection and disease course. In this study, the frequencies of CCR5 (CCR5-Δ32), CCR2 (CCR2-64I), and SDF-1 (SDF-1-3') gene polymorphisms were determined in a Jordanian population. A total of 540 subjects were randomly selected from different regions of Jordan (South, Middle, and North). Six individuals were found to carry the CCR5-Δ32 allele (0.6%) and only in the heterozygous genotype. The frequencies of CCR2-64I and SDF1-3'A were 17.5% and 34.2%, respectively. In addition, no significant difference in the distribution of the examined polymorphisms among different regions of Jordan was detected. In conclusion, the CCR5-Δ32 allele is rare, whereas the CCR2-64I and SDF1-3'A alleles are common among Jordanians.

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Section: Introductionmentioning

confidence: 99%

Distribution OfCCR-5Δ32,CCR2-64I, andSDF-1-3′AAlleles Among Jordanians

Khabour

Abu-Haweleh²,

Alzoubi³

2013

AIDS Research and Human Retroviruses

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“…The combined genotypes CT/TT also contribute to the higher risk of HIV-1 infection, indicating that the T allele of CCR5 59653 has a negative effect on HIV-1 infection for its carriers. No other associations between the allelic and genotypic frequencies and susceptibility to HIV-1 infection reached statistical significance ( p > 0.05), which is not consistent with previous reports in other ethnic populations (Kostrikis et al, 1999;Clegg et al, 2000;de Souza et al, 2006;Kaur et al, 2007). Some scholars accepted the concordant conclusion that HIV-1-infected individuals carrying the CCR5 59029-GG genotype progress to AIDS more slowly than those carrying CCR5 59029-AA (McDermott et al, 1998;Clegg et al, 2000;Knudsen et al, 2001;Kaur et al, 2007).…”

Section: Discussionmentioning

confidence: 59%

“…The allele of CCR5-D32 is common in the European populations, but almost absent from the African and Asian populations (Martinson et al, 1997). In addition, the CCR5 promoter polymorphisms, CCR5 59029-G homozygotes, were associated with delayed disease progression compared with the CCR5 59029-A homozygotes (McDermott et al, 1998;Clegg et al, 2000;Knudsen et al, 2001;Kaur et al, 2007); while CCR5 59353-C was reported to be associated with HIV pathogenesis in the Korean populations ( Jang et al, 2008), as well as with increased risk of vertical transmission of HIV-1 infection in Brazilian children (de Souza et al, 2006). In the Northern Chinese population, no significant association was found on the single-nucleotide polymorphism (SNPs) in the CCR5 promoter region.…”

Section: Introductionmentioning

confidence: 97%

The Genetic Associations and Epistatic Effects of theCCR5Promoter andCCR2-V64I Polymorphisms on Susceptibility to HIV-1 Infection in a Northern Han Chinese Population

Sheng²,

Wang³

et al. 2012

Genetic Testing and Molecular Biomarkers

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The outcome of human immunodeficiency virus (HIV)-1 infection and course to AIDS are variable among individuals. Both chemokine receptor 5 (CCR5) and CCR2 gene polymorphisms play essential roles in the susceptibility of HIV-1 infection. To investigate the main and epistatic effects of the CCR5 promoter and CCR2-V64I polymorphisms on HIV-1 infection in the Northern Han Chinese, subjects of 91 HIV-1-infected patients and 91 health controls were recruited. Single-nucleotide polymorphisms (SNPs) in the CCR5 promoter region and CCR2-V64I variants were genotyped. In the single-locus analysis, CCR5 58755-G and CCR5 59653-T alleles were significantly associated with HIV-1 infection (odds ratio [OR]=0.529, 95% confidence interval [CI]: 0.295-0.948; OR=1.710, 95% CI: 1.039-2.814). After adjustment with age and gender, subjects with the CCR5 59653-CT genotype showed the increased risk of HIV-1 infection compared with those with the wild-type CC genotype (adjusted OR=2.502; 95% CI: 1.332-4.698). No positive association was observed in other SNPs. Haplotype-based association analysis revealed that the haplotype TATGC was associated with the susceptibility to HIV-1 infection (p=0.003). Besides, we found the significant epistatic effects between the CCR5 58755-A/G and CCR5 59029-A/G polymorphisms associated with the lower risk of HIV-1 infection. In addition, we also identified the best three-factor interaction model, including the CCR5 58755-A/G, 59029-A/G, and CCR2-V64I polymorphisms, indicating that there were also strong gene-gene interactions between the CCR5 promoter and CCR2 polymorphisms on the susceptibility of HIV-1 infection. These findings contribute to understanding the genetic mechanism for the susceptibility of HIV-1 infection in Northern Han Chinese.

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“…As in adults, a single or a few founder variants are typically transmitted (Hahn et al, 2003;Renjifo et al, 2003;Verhofstede et al, 2003;Ramakrishnan et al, 2005Ramakrishnan et al, , 2006Gray et al, 2007a;Kourtis et al, 2011;Mabuka et al, 2013). Fetal or neonatal gene polymorphisms in IL-1, stromal cell-derived factor 1, Toll-like receptor 9, CCR5 (the HIV coreceptor), CCL3L1 (the ligand for CCR5), the Fc receptor γRIIA, CCR2 (a receptor that mediates the migration of monocytes to tissues), and the HLA alleles class I and II of the mother and of the fetus also affect perinatal transmission of HIV (Brouwer et al, 2004(Brouwer et al, , 2005Pillay and Phillips, 2005;De Souza et al, 2006;Kuhn et al, 2007;Ricci et al, 2010;Gianesin et al, 2012;Ahir et al, 2013). Several obstetrical events and practices, such as the duration of membrane rupture and cesarean section, increase or decrease HIV transmission, respectively (Cotter et al, 2012;Briand et al, 2013).…”

Section: Maternal To Child Transmissionmentioning

confidence: 99%