Distribution OfCCR-5Δ32,CCR2-64I, andSDF-1-3′AAlleles Among Jordanians

Khabour, Omar F.; Abu-Haweleh, Laila J.; Alzoubi, Karem H.

doi:10.1089/aid.2012.0107

Cited by 7 publications

(4 citation statements)

References 32 publications

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“…In Portugal, one of the countries that has most significantly influenced the genetic background of the Brazilian population, a frequency of 8% was reported for the general population, which is at the limit of statistical significance when compared with the frequency observed in this study (P = 0.05) (Carvalho et al, 2014). In Middle Eastern countries, variation in the allele-D32 frequency was more apparent, ranging from 0.6-14%, with the highest frequencies found in Turkey (9.1%) and Israel (14.3 %) (P < 0.05) (Martinson et al, 2000;Khabour et al, 2013;Tanyel et al, 2013). In contrast, allele-D32 is rarely seen in Asian and African countries (Table 4).…”

Section: Discussioncontrasting

confidence: 60%

Prevalence of CCR5-Δ32 and CCR2-V64I polymorphisms in a mixed population from northeastern Brazil

Ferreira-Fernandes

et al. 2015

Genet. Mol. Res.

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ABSTRACT. Chemokines are low-molecular weight proteins that play a key role in inflammatory processes. Genomic variations in chemokine receptors are associated with the susceptibility to various diseases. Polymorphisms in chemokine receptor type 5 (CCR5)-D32 and CCR2-V64I are related to human immunodeficiency virus infection resistance, which has led to genetic association studies for several other diseases. Given the heterogeneous distribution of these polymorphisms in different global populations and within Brazilian populations, we analyzed the prevalence of CCR5-D32 and CCR2-V64I polymorphisms in a mixed population from northeastern Brazil. The study included 223 individuals from the general population of the city of Parnaíba, Piauí, who had a mean age of 73 years. Of these individuals, 37.2% were men 11711 CCR5-D32 and CCR2-V64I polymorphisms in Piauí, Brazil ©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 14 (4): 11710-11718 (2015) and 62.8% were women. Polymorphisms were analyzed using DNA extracted from peripheral blood leukocytes by using polymerase chain reaction alone (CCR5-D32) or accompanied by restriction endonuclease digestion (CCR2-V64I). In both cases, the genotypes were determined using 8% polyacrylamide gel electrophoresis and silver nitrate staining. The population conformed to Hardy-Weinberg equilibrium for both the loci studied. No individuals were homozygous for allele-D32, which was present in 1.8% of the population, whereas allele-64I was present in 13.9% of the participants studied; 74.9% were homozygous for the wild-type allele, while 22.4 and 2.7% were heterozygous and homozygous for the mutant allele, respectively. Additional studies are needed to investigate the relationship between these polymorphisms and disease etiopathogenesis in reference populations.

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Section: Discussioncontrasting

confidence: 60%

Prevalence of CCR5-Δ32 and CCR2-V64I polymorphisms in a mixed population from northeastern Brazil

Ferreira-Fernandes

et al. 2015

Genet. Mol. Res.

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“…The frequencies of the CCR2-64I allele in African populations have been higher than what has been observed in Caucasians (7%–10%), while Asian populations show a wider range from 1%–30% 22. A study on subjects selected from different regions of Jordan showed that this allele is common among Jordanians, with a prevalence of 17.5% 8. The CCR2-64I mutation appears to be common in all ethnic groups,10 and the observation is in accordance with the theory that it is an ancient one 23.…”

Section: Discussionmentioning

confidence: 90%

CCR2 Genetic Polymorphism And Its Potential Effect On HIV Acquisition In A Population Of Children Living In The Northern Region Of Cameroon

Ngoufack

Nkenfou

Tiedeu

et al. 2019

TACG

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Background and objectivesThe association of chemokine receptor-2 (CCR2) polymorphism with HIV transmission or disease progression remains highly controversial. The role of CCR2-64I allele in HIV infection may differ from one population to another because of their genetic background. The objectives of this study were to characterize the CCR2 genetic polymorphism and to determine its potential effect in HIV acquisition in children living in the Northern Region of Cameroon.Materials and methodsA cross-sectional study was carried out in five health facilities in the Northern region of Cameroon. DNA was extracted from the Buffy coat of each participant using the QIAamp®DNA mini kit. The DNA extract was then subjected to polymorphic analyses. CCR2 genotypes were analyzed by polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP). The Chi-Squared test was used for the assessment of the Hardy-Weinberg equilibrium.ResultsA total of 134 children under 15 years comprised of 38 HIV-exposed infected (28.36%) and 96 HIV-exposed un-infected (71.64%) participants were recruited. Prevalences of 44.78% wild type homozygous, 48.52% heterozygous and 6.7% mutant homozygous alleles were found in the overall population. An allelic frequency of 29.69% for the mutant allele CCR2-64I was found in HIV-exposed un-infected individuals as compared to 34.21% in HIV-infected children (p=0.47).ConclusionThe CCR2-64I allele is relatively common in the Northern Region of Cameroon, with a similar distribution among HIV-exposed un-infected and infected children. As this allele alone does not seem to confer protection against HIV-1 infection, further studies using genotype-combination of CCR2 polymorphism and other single nucleotide polymorphisms would be of great relevance in both HIV prevention and novel therapeutic strategies.

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“…The SDF1‐3′A allele frequency ranges widely across different global populations ranging from 1% to 43%. SDF1‐3′A allele frequency has been reported to be high in Asians and Arabs (Voevodin et al ., ; Ikegawa et al ., ; Ramana et al ., ; Wang et al ., ; Verma et al ., ; Salem et al ., ; Amara et al ., ; Khabour et al ., ) in contrast to very low SDF1‐3′A allele frequency in Africans (Magierowska et al ., ; Petersen et al ., ), Table S1.…”

Section: Resultsmentioning

confidence: 99%

Analysis of CCR5 and SDF‐1 genetic variants and HIV infection in Indian population

Gupta

Padh

2015

Int J Immunogenetics

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HIV-1 infection and progression exhibits interindividual variation. The polymorphism in the chemokine receptors CCR5 and CXCR4, the principal coreceptors for HIV-1 and their ligands like SDF-1 have a profound effect in altering the HIV-1 disease progression rate. A single nucleotide polymorphism designated SDF1-3'UTR-801G-A has been associated with resistance to HIV-1 infection or delayed progression to AIDS. In this study, the SDF1-3'A polymorphism, CCR5∆32 polymorphism and CCR5 promoter polymorphism at positions 58934 G/T, 59029 G/A, 59353 T/C, 59356 C/T, 59402 A/G and 59653 C/T were analysed in Indian population. The polymorphisms in HIV-1 patients and healthy individuals were evaluated by conventional PCR, RFLP-PCR and direct sequencing techniques. The CCR5∆32 mutant allele was found to be almost absent in Indian population. The analysis of the CCR5-59356C/T polymorphism revealed a trend towards an association of the C allele with an increased risk of HIV-1 infection. The frequency of allele CCR5-59356C was higher in HIV-1 patients (100%) as compared to healthy control subjects (89%, P = 0.003). The correlation of SDF1-3'A and CCR5 promoter CCR5-58934G/T, CCR5-59029G/A, CCR5-59353T/C, CCR5-59402 A/G and CCR5-59653C/T polymorphisms and protection to HIV-1 infection and progression to AIDS was found to be nonsignificant. Nine haplotypes with more than 1% frequency were detected but were not significant in their protective role against HIV. Comparative analysis with global populations showed a noteworthy difference in CCR5 and SDF-1 polymorphisms' frequency distribution, indicating the ethnic variability of Indians. Although susceptibility to infections cannot be completely dependent on one or few genetic variants, it is important to remember that SDF-1 and CCR5 variants have been correlated globally with HIV-1 infection and disease progression. In the light of that, higher frequency of SDF-1 variants in the Indian population is noteworthy.

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Distribution OfCCR-5Δ32,CCR2-64I, andSDF-1-3′AAlleles Among Jordanians

Cited by 7 publications

References 32 publications

Prevalence of CCR5-Δ32 and CCR2-V64I polymorphisms in a mixed population from northeastern Brazil

Prevalence of CCR5-Δ32 and CCR2-V64I polymorphisms in a mixed population from northeastern Brazil

<p>CCR2 Genetic Polymorphism And Its Potential Effect On HIV Acquisition In A Population Of Children Living In The Northern Region Of Cameroon</p>

Analysis of CCR5 and SDF‐1 genetic variants and HIV infection in Indian population

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