CCL20/CCR6 expression profile in pancreatic cancer

Rubie, Claudia; Frick, Vilma Oliveira; Ghadjar, Pirus; Wagner, Mathias; Grimm, Henner; Vicinus, Benjamin; Justinger, Christoph; Graeber, Stefan; Schilling, Martin K.

doi:10.1186/1479-5876-8-45

Cited by 58 publications

(46 citation statements)

References 38 publications

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“…(Mrizak et al , 2015) CCL20 is certainly up-regulated in PDAC tissue at both the mRNA and protein level although whether this is secreted in exosomes is still to be determined. (Rubie et al , 2010) IL-2 is a key regulator of the proliferation and differentiation of a variety of innate immune cell subsets including CD8 + T-Cells, NK cells and Tregs. (Boyman et al , 2015) Clayton et al have demonstrated that exosomes derived from a variety of tumour cell lines inhibit the IL-2 induced proliferation of predominantly CD4 + T-Cells although this effect was not seen on CD4 + FOXP3 + Treg cells.…”

Section: Exosomes and The Adaptive Immune Response To Pdacmentioning

confidence: 99%

The role of exosomes in the pathogenesis of pancreatic ductal adenocarcinoma

Robinson

Fan

White

et al. 2016

The International Journal of Biochemistry & Cell Biology

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Section: Exosomes and The Adaptive Immune Response To Pdacmentioning

confidence: 99%

The role of exosomes in the pathogenesis of pancreatic ductal adenocarcinoma

Robinson

Fan

White

et al. 2016

The International Journal of Biochemistry & Cell Biology

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“…In pancreatic adenocarcinoma (PAC) patients, CCL20 mRNA and protein expression was found to be significantly associated with advanced T-stage [154] . It is interesting that CCR6, a canonical CCL20 receptor, is upregulated in chronic pancreatitis, pancreatic cystadenoma and pancreatic carcinoma compared to controls [154] . It has also been reported that, in metastatic pancreatic carcinoma, expression of the angiogenic chemokines CXCL5 and CXCL8 is highly elevated compared to pancreatic cystadenoma or chronic pancreatitis [138] .…”

Section: Pancreasmentioning

confidence: 99%

“…Upregulated in chronic pancreatitis, pancreatic cystadenoma and pancreatic carcinoma [154] CXCL5, CXCL8…”

Section: Ccr6mentioning

confidence: 99%

“…CCL20 is well known for its expression in various human cancers [152][153][154][155] . In pancreatic adenocarcinoma (PAC) patients, CCL20 mRNA and protein expression was found to be significantly associated with advanced T-stage [154] . It is interesting that CCR6, a canonical CCL20 receptor, is upregulated in chronic pancreatitis, pancreatic cystadenoma and pancreatic carcinoma compared to controls [154] .…”

Section: Pancreasmentioning

confidence: 99%

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Chemokines, chemokine receptors and the gastrointestinal system

Miyazaki¹,

Takabe²,

Yeudall³

2013

WJG

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Core tip: The chemokine network makes an attractive target for therapeutic intervention in many tumor types, including those of the gastrointestinal tract. However, we need to define more selective and specific targets, to minimize systemic side effects during treatment. INTRODUCTION Cancer development and progression in the gastrointestinal tractCancer is a disease in which normal cells acquire genetic and epigenetic abnormalities [1,2] , leading to disorientation of conventional processes for the maintenance of normal cell physiology. These aberrant genetic and epigenetic modifications to the normal cell induce abnormal cell motility, proliferation, and survival, eventually enabling these cells to invade into adjacent tissues and even to migrate to regional or distant organs where they may grow continuously as metastatic lesions [3] . For many cancer patients, metastasis is generally the major cause of disease-related death [4,5] . Therefore, it is indispensable to elucidate the basic molecular mechanisms of tumor development to identify effective therapeutic targets, which can possibly reduce the side-effects of treatment, and define useful molecular markers for early detection and prediction of disease course. Especially, the newly emerged concept of personalized medicine may require in-depth assessment of potential therapeutic molecular target(s) in each individual case through analysis of sig- REVIEW Chemokines, chemokine receptors and the gastrointestinal system AbstractThe biological properties of tumor cells are known to be regulated by a multitude of cytokines and growth factors, which include epidermal growth factor receptor agonists and members of the transforming growth factor β family. Furthermore, the recent explosion of research in the field of chemokine function as mediators of tumor progression has led to the possibility that these small, immunomodulatory proteins also play key roles in carcinogenesis and may, therefore, be potential targets for novel therapeutic approaches. In this review, we will summarize recently reported findings in chemokine biology with a focus on the gastrointestinal tract.

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“…In our previous studies, the role of certain chemokines was outlined in distinct gastrointestinal tumors, such as hepatocellular carcinoma, and pancreatic and colorectal cancer (7)(8)(9). Chemokine receptors are linked to seven-transmembrane heterotrimeric G proteins and divided into the chemokine (C-X-C motif) receptor (CXCR) and the chemokine (C-C motif) receptor �CCR�, which mediate a range of pro� and anti�inflammatory responses through the interaction with the two major CXC and CC subfamilies of chemokines, respectively (10).…”

Section: Introductionmentioning

confidence: 99%

CXCL12/CXCR4 display an inverse mRNA expression profile in gastric carcinoma that correlates with tumor progression

et al. 2015

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Abstract. Chemokines and their receptors have been shown to contribute to tumor growth and metastatic spread in various gastrointestinal cancer entities. In the present study, the mRNA expression profiles and clinical significance of chemokine ligand CXCL12 and its corresponding receptor CXCR4 were investigated in patients with gastric cancer (GC). Using quantitative polymerase chain reaction, the expression profile of CXCL12/CXCR4 was analyzed in resection specimens from the patients with GC (n=66) and in corresponding normal gastric tissues. Upon investigating CXCL12/CXCR4 mRNA expression levels in the GC tissues, significant downregulation of CXCL12 expression was demonstrated (P<0.05), whereas CXCR4 mRNA expression was shown to be significantly upregulated (P<0.05). Likewise, in gastric carcinoma patients undergoing neoadjuvant chemotherapy, CXCR4 expression was found to be significantly upregulated (P<0.05), whereas in GC patients with lymph and vein infiltration, CXCL12 mRNA expression was significantly downregulated �� hese results demon� (P<0.05). These results demon-. These results demonstrate a significant inverse association between the development and progress of GC and CXCL12/CXCR4 mRNA expression. CXCR4 mRNA upregulation was promoted under the effect of neoadjuvant chemotherapy prior to surgery in GC patients, whereas higher tumor stages with lymph and vein infiltration negatively affected CXCL12 mRNA expression.

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CCL20/CCR6 expression profile in pancreatic cancer

Cited by 58 publications

References 38 publications

The role of exosomes in the pathogenesis of pancreatic ductal adenocarcinoma

The role of exosomes in the pathogenesis of pancreatic ductal adenocarcinoma

Chemokines, chemokine receptors and the gastrointestinal system

CXCL12/CXCR4 display an inverse mRNA expression profile in gastric carcinoma that correlates with tumor progression

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