CCAAT/enhancer-binding protein-β has a role in osteoblast proliferation and differentiation

CCAAT/Enhancer-Binding Protein Homologous Protein (CHOP) Regulates Osteoblast Differentiation

“…This finding indicates that a cell-autonomous activity of endogenous C/EBP␤ is stimulatory for osteogenesis. However, Iyer et al reported that C/EBP␤ negatively regulates osteoblast differentiation of MC3T3-E1 cells (13). As it is possible that C/EBP␤ differentially regulates osteoblast differentiation in a cell-type-and context-dependent manner, we used primary calvarial osteoblasts to resolve this issue.…”

“…These reports strongly suggest that C/EBPs have a certain role in modifying the function of Runx2. Moreover, it has been reported that overexpression of C/EBP␤ stimulates the proliferation of a mouse osteoblastic cell line, MC3T3-E1, but suppresses its osteoblast differentiation (13). Collectively, although it is clear that C/EBPs control osteoblast differentiation in appropriate stages, it is unclear and controversial whether C/EBPs are promotive or suppressive of osteogenesis.…”

Histone demethylase Kdm4b functions as a co-factor of C/EBPβ to promote mitotic clonal expansion during differentiation of 3T3-L1 preadipocytes

“…[12][13][14][15] Despite the important role of C/EBPb in growth stimulation, the mechanism underlying MCE is not fully understood.…”

CCAAT/enhancer binding protein β-deficiency enhances type 1 diabetic bone phenotype by increasing marrow adiposity and bone resorption

“…LIP, or both) C/EBP␤ is expressed. C/EBP␤ is normally expressed during early and late stages of osteoblast differentiation, with decreased expression during middle stages (17,23). Complete knockout of C/EBP␤ in mice results in decreased total body mass and total bone mineral density (BMD) (54).…”