CBCL-pediatric bipolar disorder phenotype: severe ADHD or bipolar disorder?

Holtmann, Martin; Goth, Kirstin; Wöckel, Lars; Poustka, Fritz; Bölte, Sven

doi:10.1007/s00702-007-0823-4

Cited by 80 publications

(71 citation statements)

References 25 publications

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“…Incidentally, the CBCL-DP was previously called CBCL juvenile bipolar disorder and was used to detect juvenile bipolarity profile [44]. More recent studies have shown, however, that the CBCL-DP outcome refers to a broader dysregulation spectrum [16,17,36,43,45]. Hence, the CBCL-DP phenotype has been consistently associated with a wide range of maladaptive axis I diagnoses including ADHD, oppositional defiant disorder and conduct disorder [19,30], as was also the case in our study using the SDQ-DP.…”

Section: Discussionmentioning

confidence: 99%

“…So far no other study has been done on the SDQ-DP in the clinical setting. On the other hand, between 6 and 20% of children meet the CBCL-DP criteria in clinical samples [4,29,30,36]. Lower prevalence of the CBCL-DP may indicate higher sensitivity and/or lower specificity of the SDQ-DP at a cut-off score of ≥5.…”

Section: Discussionmentioning

confidence: 99%

“…For example, attention deficit hyperactivity disorder (ADHD), bipolar disorder, autism and schizophrenia genetic regions have been implicated in CBCL-DP susceptibility [7]. However, none of these disorders has been univocally associated with the CBCL-DP [2,16,17,36,43]. The CBCL-DP has been frequently seen in children with bipolar disorder and those who later develop bipolar disorder as young adults [5,17].…”

Section: Discussionmentioning

confidence: 99%

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Prevalence and Correlates of Psychopathology in Children and Adolescents Evaluated with the Strengths and Difficulties Questionnaire Dysregulation Profile in a Clinical Setting

Carballo

Serrano-Drozdowskyj²,

Nieto³

et al. 2014

Psychopathology

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Background: The clinical presentation of children and adolescents referred to mental health services is frequently complicated by comorbid and severe affective and behavioral dysregulation. This dysregulation phenotype seems to be an indicator of overall psychopathology, symptom severity and functional impairment. Currently, this phenotype is assessed by the Child Behavior Checklist. However, the widely used Strengths and Difficulties Questionnaire (SDQ) has been recently validated to screen the Dysregulation Profile (SDQ-DP) in clinical settings. The objective of this study was to determine the prevalence and demographic, psychosocial and clinical correlates of the SDQ-DP phenotype in a Spanish clinical sample. Sampling and Methods: In a clinical sample of 623 consecutively referred children and adolescents (4-17 years old), we compared clinical and sociodemographic correlates between subjects who met the SDQ-DP criteria (DP) and those who did not (NO_DP). Sociodemographic data, parent-rated SDQ, Children's Global Assessment Scale, Clinical Global Impression, family Apgar scale and clinical diagnoses were collected by experienced child and adolescent psychiatrists. Results: Overall in our sample, 175 subjects (28.1%) met the SDQ-DP criteria (DP group). Compared with the NO_DP group, the DP subjects had significantly higher scores on internalizing and externalizing psychopathology, problems with peers and overall problems as well as significantly lower scores on prosocial behavior. Clinical diagnoses assigned revealed that DP subjects showed significantly greater psychiatric comorbidity. DP subjects also showed significantly worse family functioning and increased symptom severity and significantly lower scores on psychosocial functioning. Conclusions: A high prevalence of children and adolescents with the dysregulated profile, assessed by the SDQ-DP, was found in our clinical setting. The SDQ-DP may serve as an index of overall psychological severity and functional impairment. In addition, it may indicate family dysfunction. Further research is needed to validate the clinical value of SDQ-DP by examining longitudinal stability, heritability, adult outcome, risk factors and diagnostic correlates.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Prevalence and Correlates of Psychopathology in Children and Adolescents Evaluated with the Strengths and Difficulties Questionnaire Dysregulation Profile in a Clinical Setting

Carballo

Serrano-Drozdowskyj²,

Nieto³

et al. 2014

Psychopathology

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“…Associations between ADHD and BPD in children is a controversial topic, as is the diagnosis of childhood mania [61,62]. This is because mania can present differently in children and adults, so that hyperactivity, mood changes and aggression can represent overlap between mania, ADHD, CD and ODD in childhood [63]. This uncertainty has led to a claim that BPD is often not recognised only in children but also to a concern that BPD is being over-diagnosed [64].…”

Section: Main Findingsmentioning

confidence: 99%

Associations of Past Oppositional Defiant Disorder in Adults with Attention-Deficit/Hyperactivity Disorder~!2008-09-19~!2008-10-22~!2008-11-28~!

Dowson¹

2008

TOPJ

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Abstract:Objective: While DSM-IV Attention-deficit/hyperactivity disorder (ADHD) comorbid with antisocial behaviours identified by DSM-IV conduct disorder (CD) has been claimed as a 'distinct subtype', there is less information about the validity of a subtype based on the more prevalent comorbidity of oppositional defiant disorder (ODD). The present study investigated the associations of past ODD with past and recent psychopathology in adults with ADHD.Methods: 94 clinic-referred adults (73 male; 21 female) with DSM-IV ADHD, and their informants, completed questionnaires.Results: 59% of males had past ODD (with or without past CD), 42% had past CD (with or without past ODD) and 36% had past ODD and past CD; for females, 57%, 33% and 29% respectively. In males with the DSM-IV ADHD 'combined' type (i.e. the most common presentation of ADHD), ratings of past ODD, when compared with those of past CD, were more strongly correlated with past and recent ADHD-related hyperactivity/impulsivity and with past and recent functional impairment. In females, ratings of past ODD, compared with those of past CD, also yielded stronger correlations with features of ADHD. In males and females, ratings of past CD (but not of ODD) were correlated with features of personality disorders. Conclusions:The results indicated that ODD ( and a history of ODD) is relevant in studies of the validity of ADHD subtypes based on comorbid antisocial behaviour. Identification of valid subtypes is important for studies of clinical course and response to treatment.

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“…Neste estudo, crianças e adolescentes com THB apresentaram T escores elevados, acima de 70, nos domínios atenção, agressividade e ansiedade/depressão (Mick et al, 2003). Entretanto, esse perfil CLCB-THB ainda não é consenso na literatura (Youngstrom et al, 2005;Holtmann et al, 2008). Os sintomas afetivos influenciam o quadro clínico e o prognóstico em indivíduos com TDAH, assim como dificultam a compreensão dos limites entre diferentes diagnósticos.…”

Section: Descriptorsunclassified

O uso da atenção como classificador diagnóstico em crianças e adolescentes com transtorno do humor bipolar e transtorno de déficit de atenção e hiperatividade

Kleinman¹

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AgradecimentosAos pacientes e seus dedicados pais, que, pela busca de se compreenderem melhor e pela esperança em nós médicos, se esforçam em nos ajudar nas pesquisas.A Beny Lafer, a admiração é tanta que dificilmente conseguirei transmitir em poucas palavras. Ser sua aluna é um privilégio. Agradeço pelo aprendizado científico, sempre instigador, vivido semanalmente. Agradeço pelas nossas reuniões específicas sobre o doutorado, que sempre me iluminaram, e pelos sábios ensinamentos sobre as relações humanas existentes no Proman.A Luis Augusto Paim Rohde, a sua coorientação foi precisa, sempre com pontuações essenciais que me permitiram melhorar, aprofundar e acreditar neste estudo.A Sheila Cavalcante Caetano, a nossa troca sempre foi um dos grandes motivadores desta pesquisa. Aprendo demais com você. E, apesar da dor inicial da separação, sei que essa parceria tão forte sempre permanecerá e redescobriremos novas formas de continuar juntas.A Helena Brentani, este trabalho não existiria sem você. Graças às nossas maravilhosas reuniões, que me ensinaram a pensar "fora da caixa", é que essas ideias surgiram borbulhantes procurando uma forma de se concretizarem.A Cristiana Rocca, este estudo não teria acontecido sem o seu olhar, sem a sua incansável dedicação e carinho. Agradeço de coração a oportunidade dessa nossa parceria.A Ênio Roberto de Andrade, por ter me aberto as portas da Psiquiatria Infantil, do Sepia e por ter sempre acreditado em mim.A Bernardo dos Santos, por tornar este estudo possível, pelas deliciosas horas de "fosforilação" estatística e pela disponibilidade, sempre alerta, para contornar as minhas angústias matemáticas com calmas explicações.A Bernardo Gomes, pelo seu apoio, pelo companheirismo, pela cumplicidade, por trazer ao Prothuia um olhar construtivo permitindo a consolidação de um grupo coeso e produtivo.A Edmir Cavalcanti Gurgel Pini Nader, querida amiga, pelo carinho e ajuda irrestrita ao longo de todos esses anos. Como agradeço o nosso incrível reencontro.Aos colegas Alessandra Bizeli Oliveira Sartori, Silvia Letícia dos Santos, Carolina Moreira, Guilherme Ferreira, Julio Renó Sawada, Ana Maria Teixeira, este trabalho é fruto desse grupo chamado Prothuia.A Taís Albuquerque e suas companheiras pela prontidão e cuidados constantes.A Cristian Zeni, agradeço todo o carinho, amizade e esforço para tornar a colaboração SP-POA possível.A todos os colegas do Proman, as nossas reuniões semanais são de um aprendizado constante, agradeço a oportunidade de fazer parte disso.A José Amaral, meu anjinho eletrônico, agradeço o carinho, a amizade e a disponibilidade de estar sempre pronto para me salvar dos sustos e entraves eletrônicos.A Karla Almeida e Lena Nabuco Abreu, pelo cuidado constante, pelas risadas e farras que trazem leveza e reenergizam o nosso dia a dia.A Eliza Fukushima e Isabel Ataide, que com muito carinho cuidaram para que tudo desse certo.Ao CNPq, pelo apoio financeiro concedido sob a forma de bolsa de estudo.A meu querido marido, Fernando, agradeço a paciência incondicional nessa long...

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CBCL-pediatric bipolar disorder phenotype: severe ADHD or bipolar disorder?

Cited by 80 publications

References 25 publications

Prevalence and Correlates of Psychopathology in Children and Adolescents Evaluated with the Strengths and Difficulties Questionnaire Dysregulation Profile in a Clinical Setting

Prevalence and Correlates of Psychopathology in Children and Adolescents Evaluated with the Strengths and Difficulties Questionnaire Dysregulation Profile in a Clinical Setting

Associations of Past Oppositional Defiant Disorder in Adults with Attention-Deficit/Hyperactivity Disorder~!2008-09-19~!2008-10-22~!2008-11-28~!

O uso da atenção como classificador diagnóstico em crianças e adolescentes com transtorno do humor bipolar e transtorno de déficit de atenção e hiperatividade

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