“…However, although relatively high levels of CB1 receptors were described in the 1990s in many olfactory brain areas of rodents [20][21][22][23], their olfactory-related functions only started to be studied during the last decade. Notably, the involvement of CB1 receptors in specific odor-related processes has been reported in specialized olfactory structures such as the olfactory epithelium (OE; [24][25][26][27]), the main olfactory bulb (MOB; [18,[28][29][30][31][32][33][34]), and the piriform cortex (PC; [35][36][37][38][39][40]), but also in other brain areas processing olfactory information [41][42][43][44]. For the sake of clarity in this review, we will focus on describing the role of the ECS, particularly CB1 receptor signaling, in specific main olfactory areas (i.e., OE, MOB, and PC).…”