Cavitary pulmonary involvement of diffuse large B-cell lymphoma transformed from extra nodal marginal zone B-cell lymphoma MALT type

Yamane, Hiromichi; Ohsawa, Masahiro; Shiote, Yasuhiro; Umemura, Shigeki; Suwaki, Toshimitsu; Shirakawa, Atsuko; Kamei, Haruhito; Takigawa, Nagio; Kiura, Katsuyuki

doi:10.1007/s12328-011-0259-0

Cited by 3 publications

(3 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Elevated LDH levels may serve as an additional diagnostic clue as they may represent tumour growth and invasive potential in neoplastic diseases. LDH was reported elevated in three cases as well as in ours 11 13 17…”

Section: Discussionsupporting

confidence: 67%

Diffuse large B cell lymphoma presenting as multiple cavitary lung lesions

Uppal,

Hassan,

Ahari

2023

BMJ Case Rep

View full text Add to dashboard Cite

A female patient in her 50s presented to the hospital with a 2 months history of shortness of breath and productive cough. She also had ongoing fatigue and unintentional weight loss. Investigations demonstrated a normal white cell count and elevated lactate dehydrogenase). A CT scan of the chest revealed multiple bilateral cavitary lung masses and pulmonary nodules. Bronchoscopy with transbronchial biopsy and fine needle aspiration of mediastinal lymph node was performed. The histopathology was consistent with the non-germinal centre B cell subtype of diffuse large B cell lymphoma (DLBCL). A regimen of rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone was started, which improved her symptoms. Although a rare presentation, this case highlights the need to consider DLBCL among the differential diagnoses for cavitary lung lesions when the workup fails to elicit an alternate cause. Given its aggressive nature, prompt diagnosis and treatment are critical.

show abstract

Section: Discussionsupporting

confidence: 67%

Diffuse large B cell lymphoma presenting as multiple cavitary lung lesions

Uppal,

Hassan,

Ahari

2023

BMJ Case Rep

View full text Add to dashboard Cite

show abstract

“…We searched on PubMed to find reports of DLBCL with cavitary lung diseases; only four cases were found in the literature (Table ) [2–5]. In all four cases, the initial diagnosis after bronchoscope was not DLBCL; two were lung abscesses, one was granulomatosis with polyangiitis, and in the remaining case transbronchial biopsy specimens revealed no malignant cell but only granulomatous infiltration.…”

Section: Discussionmentioning

confidence: 99%

Diffuse large B‐cell lymphoma presenting with cavitary lung disease

Hibino

Imai

Jinta

2020

Respirology Case Reports

View full text Add to dashboard Cite

Diffuse large B-cell lymphoma (DLBCL) with cavitary lung disease is rare and is often difficult to differentiate from primary lung cancer, granulomatous disease, or an infectious disease based on imaging findings alone. We herein report a case in which a patient with DLBCL presented with cavitary lung disease and splenic mass, which was diagnosed by transbronchial biopsy. DLBCL should be considered as a differential diagnosis in patients with cavitary lung diseases who have rare metastatic lesions for primary lung cancer, such as intra-abdominal lymph nodes or spleen.

show abstract

“…Pulmonary involvement of diffuse large B-cell lymphoma (DLBCL) is rare and even rarer is its presentation as bilateral multiple bulky mass lesions with cavitations. [1][2][3][4][5][6][7][8] In such situations it is difficult to differentiate it from granulomatous diseases, vasculitides or even a primary/ metastatic lung tumor. 9,10 Cytological evaluation of these lesions, coupled with biopsy helps solving the dilemma, but only when the material obtained is representative and optimal for examination.…”

Section: Introductionmentioning

confidence: 99%