Diffuse large B cell lymphoma presenting as cavitary lung lesions—A misleading clinical debut diagnosed by fine‐needle aspiration

Pathak, Priya; Acharya, Vishak; Rai, Santosh; Prasad, Krishna; Kamath, Sneha; Patwardhan, Maitreyi; Adiga, Deepa

doi:10.1002/dc.24878

Cited by 1 publication

(2 citation statements)

References 14 publications

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“…Only a few cases have been described with a cavitary lung lesion (table 1). Fewer still have presented with multiple cavitary lung lesions 8 9…”

Section: Discussionmentioning

confidence: 99%

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Diffuse large B cell lymphoma presenting as multiple cavitary lung lesions

Uppal,

Hassan,

Ahari

2023

BMJ Case Rep

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A female patient in her 50s presented to the hospital with a 2 months history of shortness of breath and productive cough. She also had ongoing fatigue and unintentional weight loss. Investigations demonstrated a normal white cell count and elevated lactate dehydrogenase). A CT scan of the chest revealed multiple bilateral cavitary lung masses and pulmonary nodules. Bronchoscopy with transbronchial biopsy and fine needle aspiration of mediastinal lymph node was performed. The histopathology was consistent with the non-germinal centre B cell subtype of diffuse large B cell lymphoma (DLBCL). A regimen of rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone was started, which improved her symptoms. Although a rare presentation, this case highlights the need to consider DLBCL among the differential diagnoses for cavitary lung lesions when the workup fails to elicit an alternate cause. Given its aggressive nature, prompt diagnosis and treatment are critical.

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“…Only a few cases have been described with a cavitary lung lesion (table 1). Fewer still have presented with multiple cavitary lung lesions 8 9…”

Section: Discussionmentioning

confidence: 99%

“…Of the two cases with multiple cavitary lesions, one had a known inguinal lymphoma, and the lung lesions were found during the staging workup 8. The other was suspected to have an infectious aetiology or vasculitis, and the diagnosis was delayed by 9 months from the initial CT showing the cavitations 9…”

Section: Discussionmentioning

confidence: 99%