2001
DOI: 10.1083/jcb.152.5.f29
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Caveolin, Cholesterol, and Lipid Droplets?

Abstract: Caveolins constitute the coat of caveolae, specialized domains of the plasma membrane. A large body of evidence suggests that caveolae are enriched in sphingolipids and cholesterol. Besides a role in signal transduction and in the sorting of membrane components, a diverse range of functions has been assigned to the caveolins in the cellular homeostasis of cholesterol. Cholesterol is essential for numerous membrane processes, and its concentration in the cell is governed by a delicate sensor-effector mechanism.… Show more

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Cited by 108 publications
(98 citation statements)
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“…Similar to the caveolins, it is apparently the overexpression of stomatin that targets this protein to the LBs. In other words, the transport of highly expressed caveolins or stomatin to the LBs may represent an "overflow" pathway from the ER (16). The formation of LBs and the co-localization of endogenous stomatin additionally depend on the availability of fatty acids.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Similar to the caveolins, it is apparently the overexpression of stomatin that targets this protein to the LBs. In other words, the transport of highly expressed caveolins or stomatin to the LBs may represent an "overflow" pathway from the ER (16). The formation of LBs and the co-localization of endogenous stomatin additionally depend on the availability of fatty acids.…”
Section: Discussionmentioning
confidence: 99%
“…LBs are found in most eukaryotic cells and play a role in the storage and turnover of neutral lipids, notably triacylglycerol, cholesteryl ester, and retinyl ester, depending on the cell type (15)(16)(17)(18). They are thought to originate from the membrane of the ER with newly synthesized neutral lipids being inserted between the bilayer causing the cytoplasmic leaflet to bulge and eventually bud off into the cytoplasm.…”
mentioning
confidence: 99%
“…A major hypothesis accounting for LD formation is that LDs originate from the accumulation of neutral lipids in ER membranes. The synthesis of neutral lipids leads to their accumulation in a space between the leaflets of the membranous bilayers of the ER, with subsequent budding off of LDs from it (14,(40)(41)(42). A part of proteins identified in LDs may be transferred from ER membranes to LDs in the course of LD formation.…”
Section: Localization Of Acsl3 In Lds and Cellular Membranesmentioning
confidence: 99%
“…8,9 Initially considered to be mere conduits for endocytosis, caveolae are now recognized to have pleiotropic effects on numerous cellular events. Caveolin family members have been proposed to participate in vesicular trafficking , 10 lipid metabolism , 11,12 and various signal transduction processes. The "caveolae signaling hypothesis" states that caveolae serve as an integrated platform to concentrate and modulate the activity of specific lipidmodified signaling molecules, including Src family tyrosine kinases, H-Ras, eNOS, and heterotrimeric G proteins.…”
mentioning
confidence: 99%