Cav-1 promotes atherosclerosis by activating JNK-associated signaling

Wang, Dongxia; Pan, Yongquan; Liu, Bing; Dai, Li

doi:10.1016/j.bbrc.2018.05.036

Cited by 26 publications

(23 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Lin et al [16] revealed that ox-LDL upregulates caveolin-1 phosphorylation, which leads to HUVEC apoptosis and macrophage recruitment, suggesting that caveolin is positively associated with inflammation. Caveolin also exerts inflammation-regulatory effects by modulating inflammatory signaling pathways including NF-kB and MAPK [17]. Further, caveolin directly interacts with and binds eNOS [6], Toll-like receptor (TLR-4), ERK, and Akt [4].…”

Section: 1mentioning

confidence: 99%

“…Caveolin plays a critical role in atherosclerosis by modulating inflammation or vascular remodeling in vascular smooth muscle cells. Wang et al revealed that caveolin-1 promotes atherosclerosis in ApoE −/− mice by upregulating ox-LDL-induced inflammation in vascular smooth muscle cells, which is mediated by JNK activation [17]. Similarly, Forrester SJ et al [28] revealed that caveolin-1 +/+ mice show increased AngII-induced vascular remodeling.…”

Section: Caveolin and Phonotypic Changes In Smooth Muscle Cellsmentioning

confidence: 99%

See 1 more Smart Citation

Caveolin as a Novel Potential Therapeutic Target in Cardiac and Vascular Diseases: A Mini Review

Tian¹,

Popal²,

Huang³

et al. 2020

Aging and disease

View full text Add to dashboard Cite

Caveolin, a structural protein of caveolae, play roles in the regulation of endothelial function, cellular lipid homeostasis, and cardiac function by affecting the activity and biogenesis of nitric oxide, and by modulating signal transduction pathways that mediate inflammatory responses and oxidative stress. In this review, we present the role of caveolin in cardiac and vascular diseases and the relevant signaling pathways involved. Furthermore, we discuss a novel therapeutic perspective comprising crosstalk between caveolin and autophagy.

show abstract

Section: 1mentioning

confidence: 99%

Section: Caveolin and Phonotypic Changes In Smooth Muscle Cellsmentioning

confidence: 99%

Caveolin as a Novel Potential Therapeutic Target in Cardiac and Vascular Diseases: A Mini Review

Tian¹,

Popal²,

Huang³

et al. 2020

Aging and disease

View full text Add to dashboard Cite

show abstract

“…Activated by TNF-α, CAV-1 reduces 3T3-L1 cell differentiation and blocks insulin-mediated glucose uptake [56]. CAV-1 was associated with lipoprotein metabolism, lipolysis [57], cholesterol homeostasis [58], fatty acid intake [59], and atherosclerosis [60], so CAV-1 played key regulation role in adipogenic differentiation and glycolipid metabolism.…”

Section: Discussionmentioning

confidence: 99%

LncRNA IMFlnc1 Promotes Porcine Intramuscular Adipocyte Adipogenesis by Sponging Mir-199a-5p to Up-regulate CAV-1

Wang

Chen

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: Local Chinese local pig breeds have thinner muscle fiber and higher intramuscular-fat (IMF) content. But its regulation mechanism has not been discussed in-depth. Studies indicated that long non coding RNAs (lncRNAs) play important role in muscle and fat development.Results: The lncRNAs expressional differences in the longissimus dorsi (LD) muscle were identified between Huainan pigs (local Chinese pigs, fat-type, HN) and Large White pigs (lean-type, LW) at 38, 58, and 78 days post conception (dpc). In total, 2131 novel lncRNAs were identified in 18 samples, and 291, 305, and 683 differentially expressed lncRNAs (DELs) were found between these two breeds at three stages, respectively. GO and KEGG analysis of the DEL co expressed mRNAs showed that muscle development and energy metabolism were more active at 58 dpc in HN, but at 78 dpc in LW pigs. Muscle cell differentiation and myofibril assembly might associated with earlier myogenesis and primary-muscle-fiber assembly in HN, and cell proliferation, insulin, and the MAPK pathway might contribute to longer proliferation in LW pigs. The PI3K/Akt and cAMP pathways were associated with higher IMF deposition in HN. IMFlnc1 was selected for functional verification, and results indicated that it regulated the expressional level of caveolin-1 (CAV-1) by acting as competing endogenous RNA (ceRNA) to sponge miR-199a-5p.Conclusions: Our data contributed to understanding lncRNAs in porcine-muscle development and IMF deposition, and provided valuable information for improving pig-meat quality.

show abstract

“…Activated by TNF-α, CAV-1 reduces 3T3-L1 cell differentiation and blocks insulin-mediated glucose uptake [72]. CAV-1 was associated with lipoprotein metabolism [73], lipolysis [73], cholesterol homeostasis [74], fatty acid intake [75], and atherosclerosis [76], so CAV-1 is an important regulator of adipogenic differentiation and glycolipid metabolism.…”

Section: Discussionmentioning

confidence: 99%

LncRNA IMFlnc1 promotes porcine intramuscular adipocyte differentiation by sponging miR-199a-5p to up-regulate CAV-1

Wang

Chen

et al. 2020

Preprint

View full text Add to dashboard Cite

Background Local Chinese local pig breeds have better meat quality, such as thinner muscle fiber and higher intramuscular-fat (IMF) content. However, its molecular regulation mechanism has not been discussed in-depth. Studies indicated that long non coding RNAs (lncRNAs) participate in the regulation of muscle and fat development. The expressional differences of lncRNAs in the longissimus dorsi (LD) muscle were identified between Huainan pigs (local Chinese pigs, fat-type, HN) and Large White pigs (lean-type, LW) at 38, 58, and 78 days post conception (dpc).Results In total, 2131 novel lncRNAs were identified in 18 samples, and 291, 305, and 683 differentially expressed lncRNAs (DELs) were found between these two breeds at three stages, respectively. GO and KEGG analysis of the DEL co expressed mRNAs showed that muscle development and energy metabolism were more active at 58 dpc in HN, but at 78 dpc in LW pigs. Muscle cell differentiation and myofibril assembly might contribute to earlier myogenesis and primary-muscle-fiber assembly in HN, and cell proliferation, insulin, and the mitogen-activated protein kinase (MAPK) pathway might contribute to longer proliferation in LW pigs. The PI3K/Akt and cAMP pathways were associated with higher IMF deposition in HN. IMFlnc1 was selected for functional verification, and results indicated that it regulated the expressional level of caveolin-1 (CAV-1) as a competing endogenous RNA (ceRNA) for miR-199a-5p.Conclusion Our data contributed to understanding lncRNAs in porcine-muscle development and IMF deposition, and provided valuable information for improving pig-meat quality.

show abstract

Cav-1 promotes atherosclerosis by activating JNK-associated signaling

Cited by 26 publications

References 33 publications

Caveolin as a Novel Potential Therapeutic Target in Cardiac and Vascular Diseases: A Mini Review

Caveolin as a Novel Potential Therapeutic Target in Cardiac and Vascular Diseases: A Mini Review

LncRNA IMFlnc1 Promotes Porcine Intramuscular Adipocyte Adipogenesis by Sponging Mir-199a-5p to Up-regulate CAV-1

LncRNA IMFlnc1 promotes porcine intramuscular adipocyte differentiation by sponging miR-199a-5p to up-regulate CAV-1

Contact Info

Product

Resources

About