Causes of Heterochromia Iridis with Special Reference to Paralysis of the Cervical Sympathetic

Abstract

This abstract of a candidate's thesis presented for membership in the American Ophthalmological Society, includes the reports of cases, a general review of the literature of the subject, the results of experiments, and histologic observations on the effect of extirpation of the cervical sympathetic in the rab'bit, the conclusions reached from the investigation, and a bibliography. P. P. CALHOUN Primary.. Acquired submit the following as a working basis of study: { Heredity. Sympathetic paralysis. Cyclitis and cataract. With [-Sympathetic paror J alysis. without T Cyclitis or Calais ract. Injuries. Sidero-{ [" sis bulbi. J Uveal infection-] Myopia. I Glaucoma.

Don’t it make my blue eyes brown: heterochromia and other abnormalities of the iris

“…In 1893 Angelucci noted a de-pigmentation of the uveal tract of dogs and rabbits, which had been subjected to surgical excision of the superior cervical ganglion, 16 and in 1904 Abelsdorff 24 noted heterochromia in cats following similar procedures. Subsequently, Calhoun in 1919 25 reported a series of experiments on rabbits and rodents in which he noted that hypo-pigmentation of the iris was related to the length of survival after sympathectomy. Clinically, the association of congenital Horner's syndrome and iris de-pigmentation, producing heterochromia, is wellrecognised.…”

The Use of Thermography in Familial Congenital Horner's Syndrome

“…Our two cases are unlike the ones previously reported in that opposite sides were affected by the condition. Calhoun (1919) recorded right-sided involvement in all four affected members of his family, and three of the cases described by Durham (1958) were left-sided, although he did not mention the side affected in his other two cases. On the other hand, it is known that when uniovular twins have simple heterochromia iridis, the colour change may be on the ipsilateral or contralateral side (Mann 1937).…”

“…We know of only three such reports in the last 60 years. Calhoun (1919) described a family in which three first-degree cousins and a mutual great aunt had congenital sympathetic heterochromia iridis. Durham (1958) reported a two-year-old child with congenital Horner's syndrome whose father, an aunt, an uncle and a cousin had similar findings.…”

A case of acquired iris depigmentation as a possible complication of levobunolol eye drops

“…The effects of iris depigmentation following cervical sympathectomy in rabbits and rodents has been described in 1919 by Calhoun 3. The peripheral stroma is generally depigmented reflecting the distribution of sympathetic neurons in the above situations.…”