Causes of death within 1 year of resection for lung cancer. Early mortality after resection

Toker, Alper; Dilege, Şükrü; Ziyade, Sedat; Eroğlu, Osman; Tanju, Serhan; Yılmazbayhan, Dilek; Kiliçarslan, Z.R.; Kalayci, Goksel

doi:10.1016/j.ejcts.2004.01.012

Cited by 7 publications

(4 citation statements)

References 16 publications

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“…In recent years, with the improvement of anesthesia, surgical technique and perioperative nursing, the operative mortality relevant to pneumonectomy has significantly reduced 7 , 8 . However, there still remains considerate debate whether pneumonectomy itself is a risk factor for postoperative complications or long-term outcome 9 - 12 . Furthermore, it is still unclear whether induction therapy improves the prognosis of patients underwent pneumonectomy and the efficacy of pneumonectomy for resectable small cell lung cancer (SCLC).…”

Section: Introductionmentioning

confidence: 99%

Comprehensive study of prognostic risk factors of patients underwent pneumonectomy

Gu¹,

Wang²,

Pan³

et al. 2017

J. Cancer

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Introduction: To investigate postoperative complications and the prognostic risk factors of patients underwent pneumonectomy. Methods: Four hundred and six patients underwent pneumonectomy were subjected to the study. All the clinicopathologic data including age, gender, smoking history, surgical treatment, postoperative complications, tumor staging and the follow-up information were investigated. Results: The 30-day and 90-day mortality rates were 3.2% and 6.2%, respectively. Postoperative complications developed in 149 patients (36.7%), mainly included arrhythmia, transfusion, pulmonary infection, bronchopleural fistula and acute respiratory distress syndrome. During the follow-up, 189 patients experienced a relapse, consisting of 51 patients with local recurrence and 138 with distant recurrence. The median survival time was 24.4 months and the overall 1-year, 3-year and 5-year survival rates were 82.7%, 50.9% and 32.5%, respectively. Moreover, the overall 1-year, 3-year, 5-year survival rates for patients with non-small cell lung cancer (NSCLC) were 84.1%, 52.1% and 32.5%, respectively and patients with small cell lung cancer (SCLC) were 56.1%, 38.5% and 28.8%, respectively. Among NSCLCs, adenocarcinomas had a worse prognosis than squamous carcinomas. Compared to right pneumonectomy, patients with left pneumonectomy had a better prognosis. Multivariable analysis revealed ICU stay, disease stage, nodal stage and adjuvant chemotherapy were all significant predictors of overall survival (OS). Conclusions: Pneumonectomy is still a valuable and effective treatment option for patients with advanced lung cancer. Surgeons should be more cautious when patients had higher disease stage, adenocarcinoma and right-side lung cancer. Neoadjuvant chemotherapy did not affect the prognosis. Pneumonectomy could also achieve acceptable survival outcomes in well-selected SCLC patients.

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Section: Introductionmentioning

confidence: 99%

Comprehensive study of prognostic risk factors of patients underwent pneumonectomy

Gu¹,

Wang²,

Pan³

et al. 2017

J. Cancer

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“…Progression of the disease in NSCLC is usually local or distant, the latter being more common (2). Furthermore, progression of the disease is the major cause of death documented in patients treated with complete surgery (1). The risk factors identified for a major progression of the disease are advanced TNM stage, lymph node spread, nonepidermoid histology, and occurrence in males (2).…”

Section: Discussionmentioning

confidence: 99%

“…The most common progression of the disease in patients undergoing surgery for non‐small cell lung cancer (NSCLC) is distant recurrence followed by intrathoracic recurrence (1,2). Brain, bone, hepatic tissue, and adrenal tissue are the most common sites of distant metastases, in descending order.…”

mentioning

confidence: 99%

Surgical Treatment of Solitary Metastasis in the Male Breast from Non-Small Cell Lung Cancer

Gómez-Caro

Piñero²,

Roca

et al. 2006

Breast Journal

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“…Risk of secondary occurrence of cancer/metastases after resection of the primary tumor was assumed to be 9.80% [ 29 ]. Annual mortality rate of curative patients was set to 4.7% and to 36.0% for palliative patients [ 28 , 32 , 33 ].…”

Section: Methodsmentioning

confidence: 99%

Cost-Effectiveness of Artificial Intelligence Support in Computed Tomography-Based Lung Cancer Screening

Ziegelmayer

Graf

Makowski

et al. 2022

Cancers

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Background: Lung cancer screening is already implemented in the USA and strongly recommended by European Radiological and Thoracic societies as well. Upon implementation, the total number of thoracic computed tomographies (CT) is likely to rise significantly. As shown in previous studies, modern artificial intelligence-based algorithms are on-par or even exceed radiologist’s performance in lung nodule detection and classification. Therefore, the aim of this study was to evaluate the cost-effectiveness of an AI-based system in the context of baseline lung cancer screening. Methods: In this retrospective study, a decision model based on Markov simulation was developed to estimate the quality-adjusted life-years (QALYs) and lifetime costs of the diagnostic modalities. Literature research was performed to determine model input parameters. Model uncertainty and possible costs of the AI-system were assessed using deterministic and probabilistic sensitivity analysis. Results: In the base case scenario CT + AI resulted in a negative incremental cost-effectiveness ratio (ICER) as compared to CT only, showing lower costs and higher effectiveness. Threshold analysis showed that the ICER remained negative up to a threshold of USD 68 for the AI support. The willingness-to-pay of USD 100,000 was crossed at a value of USD 1240. Deterministic and probabilistic sensitivity analysis showed model robustness for varying input parameters. Conclusion: Based on our results, the use of an AI-based system in the initial low-dose CT scan of lung cancer screening is a feasible diagnostic strategy from a cost-effectiveness perspective.

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Causes of death within 1 year of resection for lung cancer. Early mortality after resection

Abstract: The patients with pathological stage 3 disease, with large cell histology or who had undergone pneumonectomy have a higher risk of mortality within 1 year. These patients require detailed preoperative work up in terms of metastatic disease and cardiopulmonary physiological status.

Cited by 7 publications

References 16 publications

Comprehensive study of prognostic risk factors of patients underwent pneumonectomy

Comprehensive study of prognostic risk factors of patients underwent pneumonectomy

Surgical Treatment of Solitary Metastasis in the Male Breast from Non-Small Cell Lung Cancer

Cost-Effectiveness of Artificial Intelligence Support in Computed Tomography-Based Lung Cancer Screening

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