Cause of Death Among Patients With Thyroid Cancer: A Population-Based Study

Wang, Qian; Zeng, Zhen; Nan, Junjie; Zheng, Yongqiang; Liu, Huanbing

doi:10.3389/fonc.2022.852347

Cited by 10 publications

(13 citation statements)

References 44 publications

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“…Recent years, several studies have suggested that cancer patients have a higher risk of CVD related death compared with general population (12,14). Wang's study showed that the cardiovascular mortality rates of 1, 3 and 5 years in cancer patients were 6.0%, 10.8% and 17.9%, respectively, and the total cardiovascular mortality rates were 25.8% (17).…”

Section: Discussionmentioning

confidence: 99%

“…Our study have several limitations: first, factors such as patient's comorbidities (hyperlipidemia, diabetes, dyslipidemia, obesity and history of CVDs), bad habits (alcohol use and smoking habit), family history, detailed information of radiation and chemotherapy (type, dosage, and duration) may influence CVD related death in EC patients, but these information are not included in the SEER database (12,14). Second, because only…”

Section: Discussionmentioning

confidence: 99%

“…All cause of death was referring to the total number of deaths during the follow-up period, non-cancer death included seven categories: cardiovascular disease, infectious disease, respiratory disease, kidney disease, gastrointestinal disease, external injury, and other causes of death. CVD included disease of heart, hypertension without heart disease, cerebrovascular diseases, aortic aneurysm and dissection, atherosclerosis and other diseases of arteries, arterioles, capillaries (14).…”

Section: Classification Of Cause Of Deathmentioning

confidence: 99%

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Cardiovascular disease related death among patients with esophagus cancer: A population-based competing risk analysis

et al. 2022

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The proportion of non-cancer death in patients with esophagus cancer (EC) still increasing, especially cardiovascular disease (CVD) related death. The aim of this study was assess non-cancer causes of death and identified independent risk factors of CVD related death in EC patients. Patients diagnosed with EC were extracted from the Surveillance, Epidemiology, and End Result database (SEER) database for analysis. Standardized mortality rates (SMRs) for non-EC deaths were calculated, the risk of death were assessed and compared with US general population. Multivariate competitive risk analysis were performed to select independent risk factors for death from CVD in EC patients. A total of 43739 EC patients were enrolled and 35139 died during follow-up, of which 4248 died from non-cancer cause of death. The risk of non-cancer death in EC patients was 2.27-fold higher than in the general population (SMR=2.27; 95% CI, 2.20-2.34). CVD were the most important cause of non-cancer death in EC patients, accounting for 43.4% of non-cancer of deaths. Compare with the general population, EC patients have higher risk of death from disease of heart (SMR, 2.24; 95% CI, 2.13-2.35), pneumonia and influenza (SMR, 2.92; 95% CI, 2.50-3.39), septicemia (SMR, 5.01; 95% CI, 4.30-5.79), along with other causes. Patients with advanced age and patients who received radiotherapy has higher risk of death caused by CVD, patients with female sex, poor differentiated and undifferentiated, regional and distant stage, married, diagnosed between 2010-2016 has lower risk of CVD related death, compared with patients without any treatment measures, patients received chemotherapy alone has lower risk of death from CVD. Non-cancer cause of death has become an important cause of death in EC patients. Improving public awareness of the major risk factors for non-cancer death is beneficial to the prevention and treatment of malignant tumors.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Classification Of Cause Of Deathmentioning

confidence: 99%

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Cardiovascular disease related death among patients with esophagus cancer: A population-based competing risk analysis

et al. 2022

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“…Improvements in the detection of TC and therapeutic strategies have likewise resulted in a more favorable course for this disease. Because the mortality rates for TC remained stable at around 0.5 deaths per 100,000, the number of patients surviving is on the rise (8,9).…”

Section: Introductionmentioning

confidence: 99%

Thyroid and renal cancers: A bidirectional association

Bellini

Lori

Forte³

et al. 2022

Front. Oncol.

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There is a deep interrelation between the thyroid gland and the kidney parenchyma, with dysfunction of the first leading to significant changes in renal metabolism and vice versa. Given the recognition of cancer as a systemic disease, the raise of thyroid tumors and the common association of several malignancies, such as breast cancer, prostate cancer, colorectal cancer, and other, with an increased risk of kidney disease, public health alert for these conditions is warranted. A systematic review of the current evidence on the bidirectional relationship between thyroid and renal cancers was conducted including 18 studies, highlighting patient’s characteristics, histology, time for secondary malignancy to develop from the first diagnosis, treatment, and follow-up. A total of 776 patients were identified; median age was 64 years (range: 7–76 years). Obesity and family history were identified as the most common risk factors, and genetic susceptibility was suggested with a potential strong association with Cowden syndrome. Controversy on chemo and radiotherapy effects was found, as not all patients were previously exposed to these treatments. Men were more likely to develop kidney cancer after a primary thyroid malignancy, with 423/776 (54%) experiencing renal disease secondarily. Median time after the first malignancy was 5.2 years (range: 0–20 years). With the advancement of current oncological therapy, the prognosis for thyroid cancer patients has improved, although there has been a corresponding rise in the incidence of multiple secondary malignancy within the same population, particularly concerning the kidney. Surgery can achieve disease-free survival, if surveillance follow-up allows for an early localized form, where radical treatment is recommended.

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“…Wang et al reported that the non-cancer cause was the dominant cause of death (10,387 out of 22,386) in patients with thyroid cancer. The proportion of thyroid-caused death and other cancer-caused death were 31.0 and 22.6%, respectively ( 38 ). Based on 834,510 colorectal cancer patients, Chen et al concluded that the mortality risk from non-cancer cause increased.…”

Section: Discussionmentioning

confidence: 99%

Non-cancer Causes of Death Following Initial Synchronous Bone Metastasis in Cancer Patients

Abdelazeem

Abbas

et al. 2022

Front. Med.

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PurposeTo investigate the non-cancer causes of death (COD) in cancer patients with synchronous bone metastasis (BM) that is based on the Surveillance, Epidemiology, and End Results (SEER) database.MethodsThe retrospective cohort study included malignant cancer patients with synchronous BM diagnosed from 2010 to 2018 in the SEER database. The frequencies and proportion of non-cancer COD were calculated and analyzed in different genders, ages, and races subgroups.ResultsA total of 97,997 patients were deceased and included into the current study and 6,782 patients were died of non-cancer causes with a male predominance (N = 4,515, 66.6%). Around half of deaths (N = 3,254, 48.0%) occurred within 6 months after diagnosis while 721 patients were deceased after 3 years. Lung and bronchus cancer, prostate cancer, breast cancer, kidney and renal pelvis cancer, and liver cancer were proved to be the top five cancer types resulting in non-cancer caused death. Cardiovascular and cerebrovascular diseases were the leading non-cancer cause of death (N = 2,618), followed by COPD and associated conditions (N = 553) and septicemia, infectious and parasitic diseases (N = 544). Sub-analyses stratified by gender, age and race were performed and the similar results with slightly difference were observed.ConclusionsCardiovascular and cerebrovascular diseases were the main non-cancer cause of death in cancer patients with synchronous BM. Other non-cancer causes included COPD, septicemia, infectious and parasitic diseases, and so on. These findings should be considered by physicians. Physicians can counsel cancer patients with BM regarding survivorship with death causes screening and focus on prevention of non-cancer deaths.

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Cause of Death Among Patients With Thyroid Cancer: A Population-Based Study

Cited by 10 publications

References 44 publications

Cardiovascular disease related death among patients with esophagus cancer: A population-based competing risk analysis

Cardiovascular disease related death among patients with esophagus cancer: A population-based competing risk analysis

Thyroid and renal cancers: A bidirectional association

Non-cancer Causes of Death Following Initial Synchronous Bone Metastasis in Cancer Patients

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