Non-cancer Causes of Death Following Initial Synchronous Bone Metastasis in Cancer Patients

Xu, Yao; Abdelazeem, Basel; Abbas, Kirellos Said; Lin, Yile; Wu, Haixiao; Zhou, Fei; Peltzer, Karl; Чехонин, В. П.; Li, Shu; Li, Huiyang; Ma, Wenjuan; Zhang, Chao

doi:10.3389/fmed.2022.899544

Cited by 2 publications

(3 citation statements)

References 39 publications

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“…Our previous analysis showed that non-cancer causes covered 6.9% of patients diagnosed with malignant cancer with synchronous bone metastases. Common non-cancer COD included cardiovascular and cerebrovascular diseases, COPD and associated conditions, and septicemia, infectious and parasitic diseases [5] . The population-based cohort study based on the SEER database focusing on the COD during prostate cancer survivorship reported, the risk for death from most other non-cancer causes of men with distant prostate cancer was heightened.…”

Section: Discussionmentioning

confidence: 99%

“…In the present study, we conducted a pan-cancer analysis among eighteen different cancer types. The classification of cancer types was defined according to the variable of 'Site recode ICD-O-3/WHO 2008', which was described in our previous article [5] . The mortality trend and COD among pan-cancer were analyzed and visualized.…”

Section: Primary Tumors and Cause Of Death Datamentioning

confidence: 99%

“…The risk of dying from cancer and non-cancer causes were influenced by primary cancer types, clinical stage, treatment, and age especially. Individuals diagnosed with certain cancer types, such as lung and bronchus cancer, prostate cancer [4] , breast cancer, kidney, and renal pelvis cancer, and liver cancer, were proved to be prone to die of non-cancer causes [5,6] . One of the most common non-cancer COD was reported to be cardiovascular and cerebrovascular diseases [6,7] .…”

Section: Introductionmentioning

confidence: 99%

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Age-related Disparities in Pan-Cancer Mortality and Causes of Death: Analysis of Surveillance, Epidemiology, and End Results (SEER) Data

Lin,

Li,

et al. 2024

J. Cancer

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Comprehensive analysis of mortality and causes of death (COD) in cancers was of importance to conduct intervention strategies. The current study aimed to investigate the mortality rate and COD among cancers, and to explore the disparities between age. Initially, cancer patients diagnosed between 2010 and 2019 from the surveillance, epidemiology, and end results (SEER) database were extracted. Then, frequencies and percentage of deaths, and mortality rate in different age groups were calculated. Meanwhile, age distribution of different COD across tumor types was illustrated while the standardized mortality ratios (SMR) stratified by age were calculated and visualized. A total of 2,670,403 death records were included and digestive system cancer (688,953 death cases) was the most common primary cancer type. The mortality rate increased by 5.6% annually in total death, 4.0% in cancer-specific death and 10.9% in non-cancer cause. As for cancer-specific death, the age distribution varied among different primary tumor types due to prone age and prognosis of cancer. The top five non-cancer causes in patients older than 50 were cardiovascular and cerebrovascular disease, other causes, COPD and associated conditions, diabetes as well as Alzheimer. The SMRs of these causes were higher among younger patients and gradually dropped in older age groups. Mortality and COD of cancer patients were heterogeneous in age group due to primary tumor types, prone age and prognosis of cancer. Our study conducted that non-cancer COD was a critical part in clinical practice as well as cancer-specific death. Individualized treatment and clinical intervention should be made after fully considering of the risk factor for death in different diagnosis ages and tumor types.

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Section: Discussionmentioning

confidence: 99%

Section: Primary Tumors and Cause Of Death Datamentioning

confidence: 99%