Causative Relationships of Parathyroid Hormone to Renogenic and Reniprival Cardiovacular Disease

Lehr, David

doi:10.1111/j.1749-6632.1959.tb44216.x

Cited by 39 publications

(12 citation statements)

References 53 publications

(2 reference statements)

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“…The myocardial lesions we observed resemble those described in uremic patients (18), renoprival dogs (19), and rats (10,20). The destructive arterial lesions often seen in the renoprival state were not observed in the present study.…”

Section: Discussionsupporting

confidence: 80%

The Role of the Microbial Flora in Uremia

Carter

Einheber

Bauer

et al. 1966

The Journal of Experimental Medicine

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In the preceding paper, the adverse influence of the indigenous microbial flora on rats rendered uremic by bilateral nephrectomy was shown by a comparison of the postnephrectomy survival times of germfree (GF), limited-flora, and conventionalized (CONV) rats (I). This report concerns the histopathology of these animals and the biochemical and morphologic observations on groups of G F and CONV rats sacrificed 48 and 72 hr after bilateral nephrectomy and of their controls. These studies have provided some correlations between the metabolic and structural alterations of the renoprival state. They reveal that uremic colitis is bacterially induced, that cardiovascular pathology is modified by the microbial state of the host, and provide tangible evidence of the effect of the indigenous microbial flora on the uremic host. Materials and MethodsChemistry.--Chemical determinations were made on a group of rats separate from those previously reported (1). 4-to 6-month-old germfree Fischer rats were used. Half were conventionalized a month before surgery as previously described (1). Bilateral nephrectomy or sham nephrectomy was performed as before (1) under halothane anesthesia (2). 48 or 72 hr after surgery, rats were removed from their isolators and anesthetized with halothane. 10 mg/kg body weight of sodium heparin (u.s.P., without preservative) in sterile isotonic saline were given intraperitoneally. Laparotomy was performed, the abdominal aorta was cannniated with PE 50 tubing, and the rats were exsanguinated; the variable volumes of blood collected *

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Section: Discussionsupporting

confidence: 80%

The Role of the Microbial Flora in Uremia

Carter

Einheber

Bauer

et al. 1966

The Journal of Experimental Medicine

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“…Group II -uremic rats (n = 10): In one group of animals, uremia was induced by sequential intraperitoneal injection of sodium-sulfacetylthiazole (SAT), 15 mg/kg b.w., twice weekly for 4 weeks according to a modification of the original Lehr's method [3]. All animals were weighed daily, and estimation of blood urea nitrogen (BUN) and venous hematocrit was made at two weekly intervals.…”

Section: Methodsmentioning

confidence: 99%

Acute Effects of Salmon Calcitonin on Renal Electrolyte Excretion in Intact, Thyroparathyroidectomized and Sulfacetylthiazole-Induced Uremic Rats

Kawamura¹,

Daizyo²,

Hosokawa³

et al. 1978

Nephron

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Acute effects of salmon calcitonin (CT) on renal electrolyte excretion were investigated in intact, thyroparathyroidectomized (TPTX) and uremic rats. Glomerular filtration rate did not change during CT infusion and there was no volume expansion in any experimental group. Plasma calcium levels gradually fell below the control period in each experimental group. Urinary calcium excretion increased at the early period in both intact and TPTX rats but fell below the control period with the continuous infusion of CT. In uremic rats, a decrease in plasma calcium was followed by a decrease in calcium excretion. Plasma phosphate gradually decreased and simultaneously measured phosphate excretion increased in both intact and TPTX rats. In uremic rats, however, there was no change in phosphate excretion and only a slight decrease of plasma phosphate. Phosphaturia is the result of the predominant renal action of CT and occurs even when the filtered load of phosphate decreases. In uremic animals, there appears to be a resistance to exogenous CT which manifests itself by the absence of natriuretic, calciuric and phosphaturic responses.

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“…In view of the definite preventive effect of parathyroidectomy on Na-sulfaacetylthiazole-induced cardiovascular changes suggesting the importance of calcium metabolism (Lehr and Martin, 1956;Lehr, 1959), a study on the effect of thyrocalcitonin on this well defined experimental lesion appears to be of interest.…”

mentioning

confidence: 99%

Effect of Age and Thyrocalcitonin on Myocardial Changes Induced by Sodium Sulfaacetylthiazole

et al. 1968

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SYNOPSISNa-sulfaacetylthiazole, 0.5g/kg body weight, was injected into immature and adult rats to produce obstructive nephropathy. Necrotic changes in the myocardium were found in all of the 9 adult rats of about 120days of age, whereas no such changes occured in immature animals of about 40days of age. Thyrocalcitonin, 50 mMRC units a day injected subcutaneously for one week, completely inhibited the occurrence of such myocardial lesion in adult animals, as did parathyroidectomy performed one week previously. Serum calcium was decreased from the normal adult level in thyrocalcitonin treated or parathyroidectomized animals but not in untreated immature rats. Thyrocalcitonin appears to have some effect on cardiovascular system in addition to the known effect on the bone.

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Causative Relationships of Parathyroid Hormone to Renogenic and Reniprival Cardiovacular Disease

Cited by 39 publications

References 53 publications

The Role of the Microbial Flora in Uremia

The Role of the Microbial Flora in Uremia

Acute Effects of Salmon Calcitonin on Renal Electrolyte Excretion in Intact, Thyroparathyroidectomized and Sulfacetylthiazole-Induced Uremic Rats

Effect of Age and Thyrocalcitonin on Myocardial Changes Induced by Sodium Sulfaacetylthiazole

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