Causative pathogens and antibiotic resistance in children hospitalized for urinary tract infection

Koçak, Mesut; Büyükkaragöz, Bahar; Tayfur, Aslı Çelebi; Çaltık, Aysun; Köksoy, Adem Yasin; Çizmeci, Zeynep; Günbey, Sacit

doi:10.1111/ped.12842

Cited by 32 publications

(42 citation statements)

References 19 publications

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“…In the present cohort, there was a female predominance of 67.5% as compared with other studies, but in the present study 55.8% of ESBL patients were <1 year of age, similar to a case–control study from Turkey . Kizilca et al .…”

Section: Discussionsupporting

confidence: 86%

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Urinary tract infection caused by extended‐spectrum β‐lactamase‐producing bacteria: Risk factors and antibiotic resistance

Albaramki

Abdelghani

Dalaeen

et al. 2019

Pediatrics International

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Background The aim of this study was to investigate the risk factors for acquisition of extended spectrum β‐lactamase (ESBL)‐producing bacteria in community‐acquired urinary tract infection (UTI) and to evaluate their antimicrobial resistance. Methods The medical records of hospitalized children were retrospectively evaluated. Children with ESBL‐producing bacteria UTI were matched with controls with non‐ESBL‐producing bacteria UTI of the same age and gender. Results A total of 243 patients with community‐acquired UTI in a 5 year period were evaluated, of whom 46% had UTI caused by ESBL bacteria. Seventy‐seven cases were matched with 77 controls. There were no significant differences in the clinical presentation between the two groups apart from a longer hospital stay in the ESBL group (9.1 ± 5.5 days vs 8.0 ± 4.4 days, P = 0.013). Significant potential risk factors for ESBL‐UTI were previous use of antibiotics in the last 3 months, previous hospitalization in the last 3 months, history of recurrent UTI, and presence of renal anomalies. On logistic regression analysis, history of previous hospitalization in the last 3 months (OR, 3.83; 95%CI: 1.49–9.84) was identified as an independent significant risk factor for ESBL‐UTI. There was a significantly higher resistance to amoxicillin‐clavulanate, amikacin, gentamycin and quinolones in the ESBL group compared with the control group. Conclusion Recognizing the risk factors for ESBL‐UTI helps to identify the high‐risk cases and enables proper management.

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Section: Discussionsupporting

confidence: 86%

“…This would promote ESBL presence in a dormant subclinical way. Also we did not include children in the outpatient clinics with UTI . A very recent study, however, by Hanna‐Wakim et al .…”

Section: Discussionmentioning

confidence: 99%

Urinary tract infection caused by extended‐spectrum β‐lactamase‐producing bacteria: Risk factors and antibiotic resistance

Albaramki

Abdelghani

Dalaeen

et al. 2019

Pediatrics International

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“…In addition, the high prevalence of the Gram-negative bacteria like E. coli is in agreement with previous studies (8,13,14) This report is related to the physiopathology of UTIs often associated with a strong colonization of the perineum by enteric bacteria of the gastro-intestinal tract or from the environment through catheters. Sekhsokh et al suggested that specific factors of the pathoge-nicity of E. coli play an important role, as this bacterium possesses some pili capable of binding to the urinary epithelium and preventing their elimination by urine (8).…”

Section: Discussionsupporting

confidence: 79%

“…The predominance of E. coli among the Gram-negative bacilli confirms the works of Kocak et al who showed that this bacterium was the most implicated in catheterassociated UTIs (13).…”

Section: Discussionsupporting

confidence: 75%

Catheter-Associated Urinary Tract Infections at a Hospital in Zinvie, Benin (West Africa)

et al. 2016

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Background: Urinary tract infections are one of the most common nosocomial infections. They are progressively becoming a serious and very recurrent public health problem in Africa. With respect to the limited data available on this situation in Benin, the present study was conducted. Objectives: Its objective was to determine the prevalence of the urinary tract infections among catheterized patients at a hospital in Zinvie (Benin). Patients and Methods:This prospective cross-sectional study was conducted on 60 inpatients from the Services of Emergencies, Medicine and Surgery of the hospital. Urine was collected twice per patient: 10 minutes and 48 hours after the insertion of the catheter. All urine samples were subjected to bacteriological analyses. The sensitivity of bacteria isolates was tested with prescribed antibiotics in the hospital. Hygiene practices during catheterization were recorded by direct observation using a checklist. Results: Two days later, (48 hours after the catheterization), 14 patients out of 60 (23.33%) presented with a urinary infection, of which 1 patient (1.66%) was already infected before the process. Gram-negative bacteria were the most isolated bacteria (79%), with Escherichia coli as the most identified species (63%) followed by Pseudomonas spp. (11%) and Acinetobacter spp. (5%). Gram-positive cocci isolates were essentially Staphylococcus aureus (21%). All bacteria isolates were multidrug resistant. Conclusions: Only a few number of health workers do respect hygiene rules before and after catheterization. Therefore, it is necessary to train health workers involved in such activities on good hygiene practices during catheterization.

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“…Інфекція сечових шляхів (ІСШ) є однією з осно-вних причин госпіталізації дітей до стаціонару [1]. Дані про поширеність цієї патології змушують ме-дичних працівників бути уважними ще й через ши-року різноманітність неспецифічних симптомів, притаманних для різних варіантів клінічного пере-бігу, що може спостерігатись в даних пацієнтів, -від асимптоматичного і легкого до бактеріємії та септичного шоку [2].…”

Section: вступunclassified

Резистентність До Протимікробних Препаратів Серед Клінічних Ізолятів, Виділених При Інфекції Сечових Шляхів У Дітей

Vodianyk

Grechukha

Ponyatovskiy

et al. 2021

KIDNEYS

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Актуальність. Інфекція сечових шляхів (ІСШ) — одна з основних причин госпіталізації дітей до стаціонару. Однією з основних причин неефективного лікування ІСШ у дітей є антибіотикорезистентність збудників ІСШ. Метою дослідження було визначення стану поширеності антибіотикорезистентності серед збудників інфекції сечових шляхів. Матеріали та методи. Дослідження антибіотикорезистентності проводилося на 61 клінічному ізоляті, що були виділені зі зразків сечі дітей, які були госпіталізовані з приводу захворювання на різні форми ІСШ. Визначення чутливості до 23 антимікробних препаратів здійснювалося за допомогою методу антимікробних дисків з подальшим визначенням зон затримок росту. Результати. Найбільшу ефективність щодо збудників інфекцій сечових шляхів мали представники групи аміноглікозидів (амікацин — до 91,9 % клінічних ізолятів, гентаміцин — до 82 %). Цефалоспорини ІІІ покоління мали різний рівень антибіотикорезистентності, що коливалася у межах від 11,8 % (цефтизоксим) до 42,5 % (цефподоксим). Зберігається високий рівень чутливості до синтетичних протимікробних препаратів: чутливість до фурагіну становила 89,8 %, до фосфоміцину — 86,5 %. Висновки. Рівень антибіотикорезистентності щодо збудників ІСШ значно варіює у різних антибактеріальних препаратів, а також залежно від форми ІСШ, тому проведення дослідження антибіотикорезистентності є важливим етапом в лікуванні хворих на ІСШ.

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Causative pathogens and antibiotic resistance in children hospitalized for urinary tract infection

Abstract: The prevalence of UTI with ESBL (+) bacterial strains with multi-drug resistance is increasing in the hospitalized pediatric population, therefore rational use of antibiotics is essential.

Cited by 32 publications

References 19 publications

Urinary tract infection caused by extended‐spectrum β‐lactamase‐producing bacteria: Risk factors and antibiotic resistance

Urinary tract infection caused by extended‐spectrum β‐lactamase‐producing bacteria: Risk factors and antibiotic resistance

Catheter-Associated Urinary Tract Infections at a Hospital in Zinvie, Benin (West Africa)

Резистентність До Протимікробних Препаратів Серед Клінічних Ізолятів, Виділених При Інфекції Сечових Шляхів У Дітей

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