Causative drugs and clinical outcome in Stevens Johnson Syndrome (SJS), Toxic Epidermal Necrolysis (TEN), and SJS-TEN overlap in children

Sethuraman, Gomathy; Sharma, Vinod; Pahwa, Pooja; Khetan, Pooja

doi:10.4103/0019-5154.96192

Cited by 23 publications

(10 citation statements)

References 9 publications

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“…For the meta-analysis at the study level, 11 studies [18][19][20][21][22][23][24][25][26][27][28] provided information on 12 independent comparisons of glucocorticosteroids vs supportive care (Figure 3A). Although the combined point estimate reflects a beneficial treatment effect, it was not statistically significant (OR, 0.54; 95% CI, 0.29-1.01).…”

Section: Glucocorticosteroidsmentioning

confidence: 99%

Systemic Immunomodulating Therapies for Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis

et al. 2017

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Section: Glucocorticosteroidsmentioning

confidence: 99%

Systemic Immunomodulating Therapies for Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis

et al. 2017

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“… 3 Among these drugs, sulfonamides, penicillin, and anticonvulsants are the commonest implicating agents for SJS/ TEN. 4 , 5 …”

Section: Discussionmentioning

confidence: 99%

Drug-related Stevens–Johnson Syndrome and Toxic Epidermal Necrolysis: A Review

Arora

Panwar

Gupta

2021

Indian Journal of Critical Care Medicine

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A bstract Introduction Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare, life-threatening, allergic reactions affecting the skin and mucous membranes. SJS is considered to be a milder form with less than 10% of body surface area (BSA) involvement. We report successful management of two cases of SJS and TEN. Firstly, a case of a 24-year-old female who presented with rashes over face, chest, and upper limbs after the oral intake of ciprofloxacin and local application of moxifloxacin eye drops. She developed high-grade fever and difficulty in breathing requiring intubation and lung-protective mechanical ventilation and was treated with high-dose methylprednisolone, azithromycin, soframycin skin dressings, and topical ocular antibiotics. Secondly, another case of a 16-year-old female who developed bullous eruptions over the trunk, arms, hands, face, and sole involving 60% of BSA, after oral intake of albendazole. She was diagnosed as TEN and successfully managed with sterile silver nitrate, soframycin dressings, and antibiotics. Key message Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are life-threatening, allergic reactions affecting the skin and mucous membranes. Early identification, withdrawal of the suspected drug, and early transfer to a specialized center decrease mortality. How to cite this article Arora R, Pande RK, Panwar S, Gupta V. Drug-related Stevens–Johnson Syndrome and Toxic Epidermal Necrolysis: A Review. Indian J Crit Care Med 2021;25(5):575–579.

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“…It can trigger a series of events that lead to keratinocyte apoptosis. [8][9][10][11][12][13] Most involved pharmacological classes in TEN are antiepileptics, followed by antibiotics, hypouricemic agents and NSAIDs. 11,14,15 In our case an adverse reaction to allopurinol was observed.…”

Section: Discussionmentioning

confidence: 99%

Toxic epidermic necrolysis by allopurinol: a case report

Cerra

Castagna²,

Greco

et al. 2019

Geriatr Care

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Toxic epidermal necrolysis (TEN) or Lyell’s syndrome is a rare but serious potentially fatal autoimmune dermatologic disease. It is characterized by cutaneous damage due to apoptosis of the keratinocytes with consequent dermo-epidermal separation for a >30% extension of the body surface, associated with mucosal lesions. It is due to the activation of the immune system, often following the intake of potentially toxic drugs [antibiotics, antiepileptics, non-steroidal antinflammatory drugs (NSAIDs), allopurinol] or after infection with herpetic viruses or mycoplasma. We describe the case of an 82- year-old man starting therapy of Allopurinol for hyperuricemia. After four days the patient shows an extensive erythematous rash localized to the trunk and upper limbs. The following day the rash also involves the face, tending to the confluence and after another two days, the macules turn into de-epithelized areas because of dermo-epidermal separation and the lesions involve the oral and ocular mucosa, causing dysphagia and difficulty in speaking. He was treated with steroid and antihistamine therapy, suspending the previously undertaken therapy with antibiotic and Allopurinol.

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Causative drugs and clinical outcome in Stevens Johnson Syndrome (SJS), Toxic Epidermal Necrolysis (TEN), and SJS-TEN overlap in children

Cited by 23 publications

References 9 publications

Systemic Immunomodulating Therapies for Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis

Systemic Immunomodulating Therapies for Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis

Drug-related Stevens–Johnson Syndrome and Toxic Epidermal Necrolysis: A Review

Toxic epidermic necrolysis by allopurinol: a case report

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