Causal relationship of COVID-19 on Alzheimer’s disease: an updated Mendelian randomization study

Sun, Dongren; Wang, Rui; Shi, Ziyan; Chen, Hongxi; Zhou, Hongyu

doi:10.1007/s10072-023-06807-8

Cited by 8 publications

(5 citation statements)

References 5 publications

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“…A p -value of less than 0.05 was considered statistically significant. Multiple comparisons were corrected by the simple Bonferroni method ( 24 , 25 ). The threshold of significance was set at p < 0.05/15 = 0.003, with p < 0.05 and p > 0.003 considered nominally significant.…”

Section: Methodsmentioning

confidence: 99%

Associations of vitamin D-related single nucleotide polymorphisms with post-stroke depression among ischemic stroke population

et al. 2023

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ObjectiveTo investigate the relationship between single nucleotide polymorphisms (SNPs) related to vitamin D (VitD) metabolism and post-stroke depression (PSD) in patients with ischemic stroke.MethodsA total of 210 patients with ischemic stroke were enrolled at the Department of Neurology in Xiangya Hospital, Central South University, from July 2019 to August 2021. SNPs in the VitD metabolic pathway (VDR, CYP2R1, CYP24A1, and CYP27B1) were genotyped using the SNPscan™ multiplex SNP typing kit. Demographic and clinical data were collected using a standardized questionnaire. Multiple genetic models including dominant, recessive, and over-dominant models were utilized to analyze the associations between SNPs and PSD.ResultsIn the dominant, recessive, and over-dominant models, no significant association was observed between the selected SNPs in the CYP24A1 and CYP2R1 genes and PSD. However, univariate and multivariate logistic regression analysis revealed that the CYP27B1 rs10877012 G/G genotype was associated with a decreased risk of PSD (OR: 0.41, 95% CI: 0.18–0.92, p = 0.030 and OR: 0.42, 95% CI: 0.18–0.98, p = 0.040, respectively). Furthermore, haplotype association analysis indicated that rs11568820-rs1544410-rs2228570-rs7975232-rs731236 CCGAA haplotype in the VDR gene was associated with a reduced risk of PSD (OR: 0.14, 95% CI: 0.03–0.65, p = 0.010), whereas no significant association was observed between haplotypes in the CYP2R1 and CYP24A1 genes and PSD.ConclusionOur findings suggest that the polymorphisms of VitD metabolic pathway genes VDR and CYP27B1 may be associated with PSD in patients with ischemic stroke.

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Section: Methodsmentioning

confidence: 99%

Associations of vitamin D-related single nucleotide polymorphisms with post-stroke depression among ischemic stroke population

et al. 2023

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“…22 Contrarily, UK Biobank data suggested a causal link between AD and various COVID-19 populations, including susceptibility, hospitalization, and severity groups. Sun et al also reported varying findings based on COVID-19 severity 23 (Supporting Information S1: Table 1). In light of these discrepancies, we aim to investigate the genetic expression patterns common to both diseases during their progression, uncovering shared pathological mechanisms.…”

Section: Is There a Causal Relationship Between Covid-19 And Ad?mentioning

confidence: 99%

Probing molecular pathways: Illuminating the connection between COVID‐19 and Alzheimer's disease through the endocannabinoid system dynamics

Sun,

Gao,

et al. 2024

Journal of Medical Virology

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Our study investigates the molecular link between COVID‐19 and Alzheimer's disease (AD). We aim to elucidate the mechanisms by which COVID‐19 may influence the onset or progression of AD. Using bioinformatic tools, we analyzed gene expression datasets from the Gene Expression Omnibus (GEO) database, including GSE147507, GSE12685, and GSE26927. Intersection analysis was utilized to identify common differentially expressed genes (CDEGs) and their shared biological pathways. Consensus clustering was conducted to group AD patients based on gene expression, followed by an analysis of the immune microenvironment and variations in shared pathway activities between clusters. Additionally, we identified transcription factor‐binding sites shared by CDEGs and genes in the common pathway. The activity of the pathway and the expression levels of the CDEGs were validated using GSE164805 and GSE48350 datasets. Six CDEGs (MAL2, NECAB1, SH3GL2, EPB41L3, MEF2C, and NRGN) were identified, along with a downregulated pathway, the endocannabinoid (ECS) signaling pathway, common to both AD and COVID‐19. These CDEGs showed a significant correlation with ECS activity (p < 0.05) and immune functions. The ECS pathway was enriched in healthy individuals' brains and downregulated in AD patients. Validation using GSE164805 and GSE48350 datasets confirmed the differential expression of these genes in COVID‐19 and AD tissues. Our findings reveal a potential pathogenetic link between COVID‐19 and AD, mediated by CDEGs and the ECS pathway. However, further research and multicenter evidence are needed to translate these findings into clinical applications.

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“…The research is based on publicly available GWAS summary data, which include very severe respiratory con rmed COVID (18152 cases and 1145546 controls, with 13769 participants of European being), hospitalized COVID-19 (44986 cases and 2356386 controls, with 32519 participants of European being), COVID-19 (159840 cases and 2782977 controls, with 122616 participants of European being, others come from all over the world) (23), these three COVID genotypic data are from the COVID-19 host genetics initiative. SPE (154 cases and 194266 controls, genetic data from the Finns); this data comes from the nnngen database.…”

Section: Gwas Summary Datasetsmentioning

confidence: 99%

An updated two-sample Mendelian randomization study: COVID-19 and pre-eclampsia superimposed on chronic hypertension

Tang,

Hao

2023

Preprint

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Objective: To investigate the association between COVID-19 and pre-eclampsia superimposed on chronic hypertension (SPE). Design: Two-sample Mendelian randomization study. Setting: COVID-19 Host Genetics Initiative (version R7) and FinnGen consortium (version R9). Patients: A total of 222978 cases and 6284909 controls are derived from three different COVID phenotypes of the COVID-19 Host Genetics Initiative, 154 cases, and 194266 controls with pre-eclampsia superimposed on chronic hypertension (SPE) from FinnGen. Intervention (s): None. Mains Outcome Measure: SPE. Result(s): Genetic predisposition to three different COVID phenotypes of the COVID-19 was associated with an increased risk of SPE, their IVW ORs (95% CIs) and P-values are 1.39 (1.00-1.92) and 0.04, 1.88 (1.17-3.02) and 0.008, 6.41 (1.27-32.22) and 0.02, respectively. Conclusion (s): This study based on genetic data suggests the causal potential of the association between COVID-19 and SPE.

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Causal relationship of COVID-19 on Alzheimer’s disease: an updated Mendelian randomization study

Cited by 8 publications

References 5 publications

Associations of vitamin D-related single nucleotide polymorphisms with post-stroke depression among ischemic stroke population

Associations of vitamin D-related single nucleotide polymorphisms with post-stroke depression among ischemic stroke population

Probing molecular pathways: Illuminating the connection between COVID‐19 and Alzheimer's disease through the endocannabinoid system dynamics

An updated two-sample Mendelian randomization study: COVID-19 and pre-eclampsia superimposed on chronic hypertension

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