Associations of vitamin D-related single nucleotide polymorphisms with post-stroke depression among ischemic stroke population

Sun, Dongren; Song, Mingyu; Chen, Hengshu; Zhang, Jingyuan; Liu, Fan; Luo, Shihang; Liao, Qiao; Xiao, Yeqing; Wang, Xu; Zeng, Danfeng; Tan, Zheren; Tian, Fafa; Huang, Xia

doi:10.3389/fpsyt.2023.1148047

Cited by 4 publications

(1 citation statement)

References 45 publications

(51 reference statements)

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“…Notably, Women are more susceptible to PSD than men [10], and identifying risk factors is important. Accumulating evidence suggests that PSD development is in uenced by various factors, including biological and psychosocial factors [11,12]. Treatments for PSD include pharmacological interventions, rehabilitation physiotherapy, psychotherapy, and electroconvulsive interventions [13].…”

Section: Introductionmentioning

confidence: 99%

Research Hotspots and Trends on Post-Stroke Depression: a Bibliometric Analysis

Jia,

Yu,

et al. 2024

Preprint

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Post-stroke depression (PSD) is a common neuropsychiatric consequence of stroke that can negatively impact cognitive function, somatic function recovery, and patient survival. This paper utilized bibliometric and visualized analysis to explore current research hotspots and trends in this field to identify future clinical practice directions. Researchers utilized the Web of Science Core Collection (WoSCC) to extract papers on PSD and employed tools such as CiteSpace, VOSviewer, and Scimago Graphica to visually analyze the knowledge network of authors, institutions, countries/regions, journals, cited authors, cited references, cited journals, and keywords. A total of 850 papers were extracted from WoSCC, with Robinson, RG being identified as the most influential author in this area. The most prolific institution was Wenzhou Medical University, and China emerged as the leading country in producing research on PSD. Journal of Affective Disorders was found to be the most productive journal, with the primary keywords including poststroke depression, stroke, depression, and symptom. Co-citation analysis identified Robinson, RG as the leading researcher in PSD. The top-cited journal was Stroke, and the paper titled “Poststroke Depression: A Review” was ranked the most cited. Finally, “Neurosciences & Neurology” emerged as the most frequent study category. This study provided valuable information on the hotspot and frontier in PSD research, including potential partners and institutions, as well as reference points for future research topics and development directions.

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Section: Introductionmentioning

confidence: 99%

Research Hotspots and Trends on Post-Stroke Depression: a Bibliometric Analysis

Jia,

Yu,

et al. 2024

Preprint

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Vitamin D Deficiency in the Acute Phase of Stroke May Predict Post-stroke Depression: A Systematic Review and Meta-Analysis

Tan,

Jing,

Wang

et al. 2024

J Geriatr Psychiatry Neurol

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Objective To conduct the association between vitamin D levels in the acute phase of stroke and post-stroke depression (PSD) in stroke patients. Methods Five international databases (PubMed, Web of Science, Embase, Ovid MEDLINE(R), Cochrane Library) and one Chinese database (Wanfang Data) were searched for observational studies in any language reporting on PSD and vitamin D levels tested in the acute phase of stroke in stroke patients from inception to May 2024. Data extraction and study quality assessment were conducted by two authors independently. Qualitative and quantitative analyses of data were performed. The meta-analysis was registered in the PROSPERO database (CRD42023398581). Results We included 7 studies containing 3537 participants in the systematic review and meta-analysis. All studies that met the inclusion and exclusion criteria were conducted in China. Vitamin D levels in the acute phase of stroke were lower in PSD patients compared with non-PSD patients (weighted mean difference = −14.97 nmol/L; 95% confidence interval = −19.54, −10.40). Stroke patients with vitamin D deficiency (<50 nmol/L) had an increased risk of PSD compared with stroke patients with vitamin D sufficiency (≥75 nmol/L) (odds ratio = 3.59; 95% confidence interval = 2.05, 6.27). However, the association between vitamin D insufficiency (50-75 nmol/L) and PSD were not statistically significant (odds ratio = 4.15; 95% confidence interval = 0.87, 19.78). Conclusion Vitamin D deficiency in the acute phase of stroke may be a risk factor for PSD.

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Putative Pharmacological Depression and Anxiety-Related Targets of Calcitriol Explored by Network Pharmacology and Molecular Docking

Kouba,

Altê,

Rodrigues

2024

Pharmaceuticals

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Depression and anxiety disorders, prevalent neuropsychiatric conditions that frequently coexist, limit psychosocial functioning and, consequently, the individual’s quality of life. Since the pharmacological treatment of these disorders has several limitations, the search for effective and secure antidepressant and anxiolytic compounds is welcome. Vitamin D has been shown to exhibit neuroprotective, antidepressant, and anxiolytic properties. Therefore, this study aimed to explore new molecular targets of calcitriol, the active form of vitamin D, through integrated bioinformatic analysis. Calcitriol targets were predicted in SwissTargetPrediction server (2019 version). The disease targets were collected by the GeneCards database searching the keywords “depression” and “anxiety”. Gene ontology (GO) and the Kyoto Encyclopedia of Genes and Genomes (KEGG) were used to analyze the intersections of targets. Network analyses were carried out using GeneMania server (2023 version) and Cytoscape (V. 3.9.1.) software. Molecular docking predicted the main targets of the network and Ligplot predicted the main intermolecular interactions. Our study showed that calcitriol may interact with multiple targets. The main targets found are the vitamin D receptor (VDR), histamine H3 receptor (H3R), endocannabinoid receptors 1 and 2 (CB1 and CB2), nuclear receptor NR1H3, patched-1 (PTCH1) protein, opioid receptor NOP, and phosphodiesterase enzymes PDE3A and PDE5A. Considering the role of these targets in the pathophysiology of depression and anxiety, our findings suggest novel putative mechanisms of action of vitamin D as well as new promising molecular targets whose role in these disorders deserves further investigation.

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Associations of vitamin D-related single nucleotide polymorphisms with post-stroke depression among ischemic stroke population

Cited by 4 publications

References 45 publications

Research Hotspots and Trends on Post-Stroke Depression: a Bibliometric Analysis

Research Hotspots and Trends on Post-Stroke Depression: a Bibliometric Analysis

Vitamin D Deficiency in the Acute Phase of Stroke May Predict Post-stroke Depression: A Systematic Review and Meta-Analysis

Putative Pharmacological Depression and Anxiety-Related Targets of Calcitriol Explored by Network Pharmacology and Molecular Docking

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