Causal Inferences Regarding Prenatal Alcohol Exposure and Childhood Externalizing Problems

D’Onofrio, Brian M.; Hulle, Carol A. Van; Waldman, Irwin D.; Rodgers, Joseph Lee; Rathouz, Paul J.; Lahey, Benjamin B.

doi:10.1001/archpsyc.64.11.1296

Cited by 140 publications

(144 citation statements)

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“…33,34 Although some research suggests a possible association, even after controlling for prenatal smoking and parental alcohol abuse or dependence, findings based on children-of-twins or differentially exposed sibling-pair designs contradict this. 2,[35][36] Conflicting findings might also reflect a gene-environment interaction. 37 Relatively few studies have examined the relationship between binge drinking and childhood hyperactivity/inattention; some have not found an association and others have not separated out binge episodes from daily drinking.…”

Section: Discussionmentioning

confidence: 99%

“…In contrast, there are mixed findings as to whether moderate (1-2 drinks per day) average levels of alcohol consumption during pregnancy are associated with childhood learning and mental health problems. [1][2][3][4][5][6][7][8][9][10] These discrepancies may reflect that intermittent episodes of heavier drinking such as binge episodes are obscured when investigating average levels. Drinking patterns may be as important as total amounts consumed in conferring risk for childhood behavioral and learning problems.…”

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confidence: 99%

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Binge Pattern of Alcohol Consumption During Pregnancy and Childhood Mental Health Outcomes: Longitudinal Population-Based Study

Heron²,

et al. 2009

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Alcohol consumption during pregnancy is a risk factor for childhood mental health and learning problems. A recent systematic review recommended research that distinguishes between risks related to intermittent binge drinking and those related to regular background levels of drinking. What This Study AddsThe occasional consumption of Ն4 drinks per day during pregnancy is associated with child mental health problems in the absence of moderate daily levels of drinking. The main risks relate to hyperactivity and inattention problems. ABSTRACTOBJECTIVE. Patterns of alcohol consumption during pregnancy such as episodes of binge drinking may be as important as average levels of consumption in conferring risk for later childhood mental health and learning problems. However, it can be difficult to distinguish risk resulting from episodic or regular background levels of drinking. This large study investigates whether patterns of alcohol consumption are independently associated with child mental health and cognitive outcomes, whether there are gender differences in risk, and whether occasional episodes of higher levels of drinking carry any risk in the absence of regular daily drinking during pregnancy.METHODS. This prospective, population-based study used data from the Avon Longitudinal Study of Parents and Children. We investigated the relationships between a binge pattern of alcohol use (consumption of Ն4 drinks in a day) in the second and third trimesters of pregnancy and childhood mental health problems at 47 and 81 months of age (n ϭ 6355 and 5599, respectively). In a subgroup, we also investigated these relationships with child IQ at 49 months of age (n ϭ 924). RESULTS.After controlling for a range of prenatal and postnatal factors, any episodes of consuming Ն4 drinks in a day were independently associated with higher risks for mental health problems (especially hyperactivity/inattention) in girls at the age of 47 months and in both genders at 81 months. There was no association with IQ scores at 49 months after adjustment for confounders. The consumption of Ն4 drinks in a day continued to carry risk for mental health problems (especially hyperactivity/ inattention) in the absence of regular daily drinking.CONCLUSIONS. The consumption of Ն4 drinks in a day on an occasional basis during pregnancy may increase risk for child mental health problems in the absence of moderate daily levels of drinking. The main risks seem to relate to hyperactivity and inattention problems. Pediatrics 2009;123:e289-e296

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

Binge Pattern of Alcohol Consumption During Pregnancy and Childhood Mental Health Outcomes: Longitudinal Population-Based Study

Heron²,

et al. 2009

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“…42 Children exposed prenatally to alcohol can become hyperactive, disruptive, impulsive, and are at an increased risk for a range of psychiatric disorders. 43,44 Maternal smoking produces a 2.7-fold increased risk for ADHD 45 and a dose-response relationship between maternal smoking during pregnancy and hyperactivity has been reported. 46 Nicotinic receptors modulate dopaminergic activity, and dopaminergic disruption is believed to be involved in the pathophysiology of ADHD.…”

Section: Environmental Risk Factorsmentioning

confidence: 99%

The neurobiology of attention deficit/hyperactivity disorder

Curatolo

Paloscia

D’Agati

et al. 2009

European Journal of Paediatric Neurology

113

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“…As may be expected, many children with FASD have comorbid ADHD (Fryer, McGee, Matt, Riley, & Mattson, 2007;Rasmussen et al, 2010), although careful analysis finds some differences from an ADHD population (Mattson, Crocker, & Nguyen, 2011). Prenatal alcohol exposure in the first trimester of pregnancy has been found to be significantly associated with an increased rate of conduct disorder (Disney, Iacono, McGue, Tully, & Legrand, 2008;D'Onofrio et al, 2007;Larkby, Goldschmidt, Hanusa, & Day, 2011), and behavior problems with FASD do persist into adulthood (Barr et al, 2006;Famy, Streissguth, & Unis, 1998;Spohr, Willms, & Steinhausen, 2007).…”

Section: Introductionmentioning

confidence: 95%

Lens Neurofeedback Treatment with Fetal Alcohol Spectrum Disorder and Neglect

Hammond

2012

Journal of Neurotherapy

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Causal Inferences Regarding Prenatal Alcohol Exposure and Childhood Externalizing Problems

Abstract: These results are consistent with PAE exerting an environmentally mediated causal effect on childhood CPs, but the relation between PAE and AIPs is more likely to be caused by other factors correlated with maternal drinking during pregnancy.

Cited by 140 publications

References 53 publications

Binge Pattern of Alcohol Consumption During Pregnancy and Childhood Mental Health Outcomes: Longitudinal Population-Based Study

Binge Pattern of Alcohol Consumption During Pregnancy and Childhood Mental Health Outcomes: Longitudinal Population-Based Study

The neurobiology of attention deficit/hyperactivity disorder

Lens Neurofeedback Treatment with Fetal Alcohol Spectrum Disorder and Neglect

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