Caudal thoracic air sac cannulation in zebra finches for isoflurane anesthesia

Nilson, Paige Crystal; Teramitsu, Ikuko; White, Stephanie A.

doi:10.1016/j.jneumeth.2004.09.014

Cited by 29 publications

(9 citation statements)

References 17 publications

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“…4,10,11,16 Compared with an inhalant anesthesia, the use of an injectable agent may reduce the time to induce anesthesia, minimize equipment needs, and lower costs. 8 However, in small birds, intravenous injection can be difficult; thus, the intramuscular or subcutaneous routes are used more frequently.…”

Section: Introductionmentioning

confidence: 99%

COMPARISON OF INTRANASAL ADMINISTRATION OF XYLAZINE, DIAZEPAM, AND MIDAZOLAM IN BUDGERIGARS (MELOPSITTACUS UNDULATUS): CLINICAL EVALUATION

Sadegh¹

2013

Journal of Zoo and Wildlife Medicine

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Effective sedation methods are important to facilitate safe handling for diagnostic and clinical procedures for small and often delicate birds such as budgerigars (Melopsittacus undulatus). The aim of this study was to directly compare the time of onset and duration of sedation produced by intranasal administration of xylazine, diazepam, or midazolam in budgerigars. Fifteen (seven male, eight female) clinically healthy mature budgerigars weighing 28.9 +/- 6.1 g were involved in the study Each bird was used three times in a randomized crossover study design with 7 days between treatments. Birds received xylazine (25.6 +/- 2.2 mg/kg), diazepam (13.6 +/- 1.1 mg/kg), or midazolam (13.2 +/- 1.3 mg/kg) intranasally (i.n.) using a micropipette. The onset time and dorsal recumbency duration time were measured and recorded. Sedation was produced in all birds after i.n. administration of xylazine, diazepam, and midazolam. Time to onset of sedation was significantly shorter after midazolam (1.3 +/- 0.44 min) compared with that after xylazine (2.6 +/- 0.89 min) and diazepam (2.8 +/- 0.88 min). Xylazine produced significantly longer duration of sedation (286.0 +/- 28.8 min) than that produced by diazepam (165.40 +/- 19.2 min) and midazolam (71.60 +/- 8.9 min). This study demonstrated that i.n. drug administration could provide fast and reliable sedation in budgerigars. Although i.n. midazolam or diazepam can provide adequate sedation for diagnostic and minor therapeutic procedures, xylazine at the dose used in this study is not recommended because the quality of sedation may be insufficient to perform a clinical procedure.

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Section: Introductionmentioning

confidence: 99%

COMPARISON OF INTRANASAL ADMINISTRATION OF XYLAZINE, DIAZEPAM, AND MIDAZOLAM IN BUDGERIGARS (MELOPSITTACUS UNDULATUS): CLINICAL EVALUATION

Sadegh¹

2013

Journal of Zoo and Wildlife Medicine

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“…It is applied in case of respiratory tract obturation and for ventilation (Brown and Pilny, 2006) . In addition, cannulation is a convenient procedure for delivering isoflurane in zebra finches during surgery when access to the head is required (Nilson et al, 2005) . Cannulae can be left implanted for several days (Brown and Pilny, 2006) .…”

Section: Muting By Air Sac Cannulationmentioning

confidence: 99%

Welfare of zebra finches used in research

Yamahachi

Zai

Tachibana

et al. 2017

Preprint

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Over the past 50 years, songbirds have become a valuable model organism for scientists studying vocal communication from its behavioral, hormonal, neuronal, and genetic perspectives. Many advances in our understanding of vocal learning result from research using the zebra finch, a close-ended vocal learner. We review some of the manipulations used in zebra finch research, such as isolate housing, transient/irreversible impairment of hearing/vocal organs, implantation of small devices for chronic electrophysiology, head fixation for imaging, aversive song conditioning using sound playback, and mounting of miniature backpacks for behavioral monitoring. We highlight the use of these manipulations in scientific research, and estimate their impact on animal welfare, based on the literature and on data from our past and ongoing work. The assessment of harm-benefits tradeoffs is a legal prerequisite for animal research in Switzerland. We conclude that a diverse set of known stressors reliably lead to suppressed singing rate, and that by contraposition, increased singing rate may be a useful indicator of welfare. We hope that our study can contribute to answering some of the most burning questions about zebra finch welfare in research on vocal behaviors. Therefore, the interplay between corticosterone levels during development and long-term consequences of stress needs to be further studied. Skin temperatureA stressor can increase the core body temperature, provoking a decrease of the surface temperature. This phenomenon known as stress-induced hyperthermia could be utilized to measure stress. Indeed, infrared thermography has been used to determine the effect of stressful procedures in birds (Edgar et al., 2013;Herborn et al., 2015;Jerem et al., 2015) . Contrary to the stress snapshot of corticosterone, this non-invasive imaging method might provide longitudinal measurements of stress. Body weightBody weight can be used to assess body condition in birds, especially when multiple measurements are made over the course of a study (Brown, 1996;Dickens et al., 2009bDickens et al., , 2009a .

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“…When head fixation in a stereotaxic device is required, the isoflurane can be administered via a modified face mask or by taping a small (#5) French catheter just inside the oral cavity (Dr. Kvin Lertpiriyapong, personal communication); cannulation of an air sac for anesthetic gas delivery has also been described (Nilson et al, 2005). When head fixation in a stereotaxic device is required, the isoflurane can be administered via a modified face mask or by taping a small (#5) French catheter just inside the oral cavity (Dr. Kvin Lertpiriyapong, personal communication); cannulation of an air sac for anesthetic gas delivery has also been described (Nilson et al, 2005).…”

Section: Anesthesia and Analgesiamentioning

confidence: 99%