Cationization of organic molecules under keV and MeV primary ion bombardment

Jenčič, Boštjan; Ekar, Jernej; Vasić, Mirjana; Barba, Žiga; Kelemen, Mitja; Vavpetič, Primož; Kovač, Janez; Pelicon, Primož

doi:10.1016/j.ijms.2022.116983

Cited by 2 publications

(2 citation statements)

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“…Other favored factors, such as analyte migration and mitigation of matrix effects, might be the main mechanisms behind the secondary ion yield increase. Despite the secondary ion yield, enhancement did not exceed a factor of 5, which is much lower than that with some other sample alteration techniques, such as salt treatment . This result is still promising, since preparation protocols are very straightforward.…”

Section: Discussionmentioning

confidence: 76%

“…Despite the secondary ion yield, enhancement did not exceed a factor of 5, which is much lower than that with some other sample alteration techniques, such as salt treatment. 23 This result is still promising, since preparation protocols are very straightforward. The main benefit of “MetA-MeV-SIMS” is still the advancement of imaging capabilities, especially when thicker insulating samples are used.…”

Section: Discussionmentioning

confidence: 97%

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Gold-Assisted Molecular Imaging of Organic Tissue by MeV Secondary Ion Mass Spectrometry

Jenčič,

Pongrac,

Vasić

et al. 2023

J. Am. Soc. Mass Spectrom.

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The quality of molecular imaging by means of MeV primary ion-induced secondary ion mass spectrometry by coating with gold was evaluated on different reference organic molecules and plant samples. The enhancement of the secondary ion yield was evident for the majority of the studied analytes, reaching the highest values at gold thicknesses between 0.5 and 2 nm, and increased the intensity up to 5-fold for reference samples and >2fold for specific peaks within the plant sample. Improved propagation of the electric field due to the target potential on otherwise electrically insulating plant samples was also evident through improved image resolution and by reducing the background in mass spectra. However, detection of several molecules was significantly decreased at even at 1 nm thick gold layer. The results indicated that an optimized sequence of analysis is required to reliably interpret results.

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Section: Discussionmentioning

confidence: 76%

Section: Discussionmentioning

confidence: 97%