Cationic triblock copolymer micelles enhance antioxidant activity, intracellular uptake and cytotoxicity of curcumin

Yoncheva, Krassimira; Kamenova, Katya; Perperieva, Teodora; Hadjimitova, Vera; Donchev, Petar; Kaloyanov, Kaloyan; Konstantinov, Spiro; Kondeva-Burdina, Magdalena; Tzankova, Virginia; Petrov, Petar

doi:10.1016/j.ijpharm.2015.05.057

Cited by 53 publications

(23 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…observed a faster reaction between gallic acid and DPPH incorporated in Triton X-100, SDS, or CTAB micelles than those in methanol, which allowed shorter analysis time. The ability of the micellar curcumin to scavenge the ABTS radicals was higher than that of free curcumin29. A recent study demonstrated that the activity and rate of the DPPH RSA of naringenin increased with the increasing concentrations of SDS and CTAB micelles30.…”

Section: Resultsmentioning

confidence: 95%

Physical characterization and antioxidant activity of thymol solubilized Tween 80 micelles

Deng

Taxipalati

Que

et al. 2016

Sci Rep

View full text Add to dashboard Cite

Attempts were made to solubilize thymol in Tween 80 micelle to study the solubilization mechanism of thymol and the effect of solubilization on its antioxidant activity. The maximum solubilized concentration of thymol in a 2.0% (w/v) Tween 80 micelle solution is 0.2 wt%. There was no significant difference in Z-average diameter between the empty micelles and thymol solubilized micelles. 1H NMR spectra indicated that 3-H and 4-H on the benzene ring of thymol interacted with the ester group between the hydrophilic head group and the hydrophobic tail group of Tween 80 by Van der Waals’ force. Ferric reducing antioxidant potential (FRAP) and cupric ion reducing antioxidant capacity (CUPRAC) assays showed that the reducing antioxidant activity of free thymol did not change after solubilized in Tween 80 micelles. Compared to free thymol, the solubilized thymol showed higher activities to scavenge DPPH (2,2-diphenyl-1-picrylhydrazyl) and hydroxyl radicals. The present study suggested a possible preparation of thymol-carrying micelles with enhanced antioxidant activities that could be applied in food beverages.

show abstract

Section: Resultsmentioning

confidence: 95%

Physical characterization and antioxidant activity of thymol solubilized Tween 80 micelles

Deng

Taxipalati

Que

et al. 2016

Sci Rep

View full text Add to dashboard Cite

show abstract

“…Moreover, a pleiotropic effect for curcumin has been advocated and might involve antineoplastic and anticlastogenic properties by interacting with signal transduction and scavenging of free radicals at various levels in the body [35][36][37]. In this respect, the present and other formulations [38,39] containing curcumin might further improve its bioavailability and intracellular uptake ability.…”

Section: Discussionmentioning

confidence: 97%

Curcumin and Fennel Essential Oil Improve Symptoms and Quality of Life in Patients with Irritable Bowel Syndrome

Portincasa

Bonfrate

Scribano

et al. 2016

JGLD

View full text Add to dashboard Cite

show abstract

“…( Figure S1 ). Surface morphology and size are important parameters for nanoemulsion stability and interaction with biological membranes [ 30 ]. Figure S2 shows the physiochemical properties of the saponin-based vitamin nanoemulsions.…”

Section: Resultsmentioning

confidence: 99%

Saponin-Based Nanoemulsification Improves the Antioxidant Properties of Vitamin A and E in AML-12 Cells

Choudhry

Kim

et al. 2016

IJMS

View full text Add to dashboard Cite

Our work aimed to investigate the protective effects of saponin-based nanoemulsions of vitamin A and E against oxidative stress-induced cellular damage in AML-12 cells. Saponin nanoemulsions of vitamin A (SAN) and vitamin E (SEN) were prepared by high-pressure homogenization and characterized in terms of size, zeta potential, and polydispersity index. SEN and SAN protect AML-12 cells against oxidative stress-induced cellular damage more efficiently via scavenging reactive oxygen species (ROS), and reducing DNA damage, protein carbonylation, and lipid peroxidation. These results provide valuable information for the development of nanoemulsion-based delivery systems that would improve the antioxidant properties of vitamin A and E.

show abstract

Cationic triblock copolymer micelles enhance antioxidant activity, intracellular uptake and cytotoxicity of curcumin

Cited by 53 publications

References 33 publications

Physical characterization and antioxidant activity of thymol solubilized Tween 80 micelles

Physical characterization and antioxidant activity of thymol solubilized Tween 80 micelles

Curcumin and Fennel Essential Oil Improve Symptoms and Quality of Life in Patients with Irritable Bowel Syndrome

Saponin-Based Nanoemulsification Improves the Antioxidant Properties of Vitamin A and E in AML-12 Cells

Contact Info

Product

Resources

About