Cationic porphyrin-based star-shaped polymers with photo-enhanced antibacterial activity by BIT-RDRP

Ren, Shusu; Xu, Xiang; Sun, Jingbo; Zhao, Haitao; He, Weiwei; Zhang, Lifen; Cheng, Zhenping

doi:10.1016/j.eurpolymj.2023.112232

Cited by 4 publications

(3 citation statements)

References 54 publications

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“…Four-armed initiator THPP-4Br was prepared as in our previous work 45 (the synthetic route and 1 H NMR spectrum were shown in Scheme S1 and Figure S1, respectively). Polymerization of MMA employing THPP-4Br as the initiator by BIT-RDRP was conducted, THPP-4PMMA of different molar masses was prepared, and the results were listed in Table S1.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

Preparation of Porphyrin-Based Unimolecular Micelles for Synergistic Photodynamic Therapy and Radiotherapy

Song,

Ren,

et al. 2024

ACS Appl. Polym. Mater.

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Polymeric carriers have been widely used in biomedical fields because of their strong structural tunability and biocompatibility, which often proximately determine the in vivo behavior of the drug and are crucial in practical application. In this work, porphyrin-based unimolecular micelles with an average diameter less than 20 nm are developed by light-mediated bromine–iodine transformation reversible-deactivation radical polymerization (BIT-RDRP) for synergistic photodynamic therapy (PDT) and radiotherapy (RT). Tetraphenylporphyrin is designed as a four-arm initiator to afford the PDT function, which is employed to regulate the sequential polymerization of hydrophobic and hydrophilic monomers to produce star-shaped amphiphilic copolymers, followed by self-assembly in water to form unimolecular micelles. A functional monomer containing triplet pyridine ligand is prepared and introduced during the polymerization, which is to combine the radionuclide 177Lu to provide the RT function. The as-prepared unimolecular micelles exhibit high-temperature and pH stability, as expected. Satisfactory accumulation and retention efficiency in tumors and fast metabolism in organs are achieved, and PDT and RT can be conducted simultaneously to enhance the therapeutic effect toward tumors. This work provides a polymeric drug with bimodal therapy, including radiotherapy, which is expected to be competitive in the field of tumor treatment.

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Section: ■ Results and Discussionmentioning

confidence: 99%

Preparation of Porphyrin-Based Unimolecular Micelles for Synergistic Photodynamic Therapy and Radiotherapy

Song,

Ren,

et al. 2024

ACS Appl. Polym. Mater.

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“…15,16 However, most of the currently reported antimicrobial polymers of this type are ionic, and their ionic interactions with cell membranes are the key to their antimicrobial activity. 17,18 Ionic polymers may have poor water solubility, poor antimicrobial performance sustainability, risk of scaling, and toxicity problems in practical applications.…”

Section: Introductionmentioning

confidence: 99%

“…Small-molecule antimicrobial agents usually include drugs (chlorine-containing, nitrogen-containing substances), , antibiotics, zinc oxide, and nanosilver, which have the advantages of small molecular weight and rapid reaction rate and can quickly cross the bacterial cell film ester structure and damage the cell matrix . However, small-molecule antimicrobial agents are susceptible to leaching and migration of antimicrobial molecules, easy-to-cause secondary environmental pollution, have physiological toxicity, and the use of a large number of small molecules of antimicrobial agents can cause bacterial resistance. , Synthetic antimicrobial polymers have stronger antimicrobial activity, lower potential to induce antimicrobial resistance, and a lower leaching risk and environmental toxicity than small-molecule antimicrobial agents. , However, most of the currently reported antimicrobial polymers of this type are ionic, and their ionic interactions with cell membranes are the key to their antimicrobial activity. , Ionic polymers may have poor water solubility, poor antimicrobial performance sustainability, risk of scaling, and toxicity problems in practical applications. Most synthetic antimicrobial polymers are petroleum-based, which are physiologically toxic, difficult to biodegrade, and cause environmental pollution. , Therefore, there is an urgent need to develop eco-friendly, efficient, biodegradable, nonleachable, and long-lasting nonionic antimicrobial polymers …”

Section: Introductionmentioning

confidence: 99%

Eco-Friendly Cellulose-Based Nonionic Antimicrobial Polymers with Excellent Biocompatibility, Nonleachability, and Polymer Miscibility

Dang,

Yu,

Wang

et al. 2023

ACS Appl. Mater. Interfaces

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This study aims to prepare natural biomass-based nonionic antimicrobial polymers with excellent biocompatibility, nonleachability, antimicrobial activity, and polymer miscibility. Two new cellulose-based nonionic antimicrobial polymers (MIPA and MICA) containing many terminal indole groups were synthesized using a sustainable one-pot method. The structures and properties of the nonionic antimicrobial polymers were characterized using nuclear magnetic resonance hydrogen spectroscopy ( 1 H NMR), infrared spectroscopy (FTIR), wide-angle X-ray diffractometry (XRD), thermogravimetric analysis (TGA), differential scanning calorimetry (DSC), scanning electron microscopy (SEM), gel chromatography (GPC), and other analytical techniques. The results showed that microcrystalline cellulose (MCC) molecules combined with indole derivatives through an esterification reaction to produce MICA and MIPA. The crystallinity of the prepared MICA and MIPA molecules decreased after MCC modification; their morphological structure changed from short fibrous to granular and showed better thermal stability and solubility. The paper diffusion method showed that both nonionic polymers had good bactericidal effects against the two common pathogenic bacteria Escherichia coli (E. coli, inhibition zone diameters >22 mm) and Staphylococcus aureus (S. aureus, inhibition zone diameters >38 mm). Moreover, MICA and MIPA showed good miscibility with biodegradable poly(vinyl alcohol) (PVA), and the miscible cellulose-based composite films (PVA-MICA and PVA-MIPA) showed good phase compatibility, light transmission, thermal stability (maximum thermal decomposition temperature >300 °C), biocompatibility, biological cell activity (no cytotoxicity), nonleachability, antimicrobial activity, and mechanical properties (maximum fracture elongation at >390%).

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Graphitic carbon nitride (g-C3N4) as an efficient and recyclable catalyst for iodine-mediated RCMP

Zhou,

Wang,

Wang

et al. 2024

European Polymer Journal

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Cationic porphyrin-based star-shaped polymers with photo-enhanced antibacterial activity by BIT-RDRP

Cited by 4 publications

References 54 publications

Preparation of Porphyrin-Based Unimolecular Micelles for Synergistic Photodynamic Therapy and Radiotherapy

Preparation of Porphyrin-Based Unimolecular Micelles for Synergistic Photodynamic Therapy and Radiotherapy

Eco-Friendly Cellulose-Based Nonionic Antimicrobial Polymers with Excellent Biocompatibility, Nonleachability, and Polymer Miscibility

Graphitic carbon nitride (g-C3N4) as an efficient and recyclable catalyst for iodine-mediated RCMP

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