Cationic polymer-derived carbon dots for enhanced gene delivery and cell imaging

He, Xi; Chen, Ping; Zhang, Ji; Luo, Tianying; Wang, Haijiao; Liu, Yanhong; Yu, Xiao‐Qi

doi:10.1039/c8bm01578c

Cited by 35 publications

(26 citation statements)

References 41 publications

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“…This suggests the significance of BP-NCDs/MC nanoconjugates as the potent gene carriers in gene delivery for cardiac injury [308]. In a study by He and team, hydrothermally prepared polymeric CDs were employed for enhancing the transfection efficiency in gene delivery [309]. Herein, the as-prepared polymeric CDs could serve as multifunctional gene vectors with excellent biocompatibility, low cytotoxicity, and strong transfection efficiency, by carrying out the luciferase assay in HeLa cells.…”

Section: Role Of Cds In Gene Delivery or Gene Therapymentioning

confidence: 99%

Carbon Dots: Classification, Properties, Synthesis, Characterization, and Applications in Health Care—An Updated Review (2018–2021)

2021

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Carbon dots (CDs) are usually smaller than 10 nm in size, and are meticulously formulated and recently introduced nanomaterials, among the other types of carbon-based nanomaterials. They have gained significant attention and an incredible interest in the field of nanotechnology and biomedical science, which is merely due to their considerable and exclusive attributes; including their enhanced electron transferability, photobleaching and photo-blinking effects, high photoluminescent quantum yield, fluorescence property, resistance to photo-decomposition, increased electrocatalytic activity, good aqueous solubility, excellent biocompatibility, long-term chemical stability, cost-effectiveness, negligible toxicity, and acquaintance of large effective surface area-to-volume ratio. CDs can be readily functionalized owing to the abundant functional groups on their surfaces, and they also exhibit remarkable sensing features such as specific, selective, and multiplex detectability. In addition, the physico-chemical characteristics of CDs can be easily tunable based on their intended usage or application. In this comprehensive review article, we mainly discuss the classification of CDs, their ideal properties, their general synthesis approaches, and primary characterization techniques. More importantly, we update the readers about the recent trends of CDs in health care applications (viz., their substantial and prominent role in the area of electrochemical and optical biosensing, bioimaging, drug/gene delivery, as well as in photodynamic/photothermal therapy).

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Section: Role Of Cds In Gene Delivery or Gene Therapymentioning

confidence: 99%

Carbon Dots: Classification, Properties, Synthesis, Characterization, and Applications in Health Care—An Updated Review (2018–2021)

2021

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“…Additionally, CDs exhibit higher cell viability and well tolerance with serum in comparison with commercially available polyethyleneimine (He et al, 2019). The sub-classes of CBNs possess different physicochemical properties like aspect ratio, surface functionalization, purity, etc., and exert different toxicological profiles (Bhattacharya et al, 2016).…”

Section: Biocompatibility and Biological Interactionsmentioning

confidence: 99%

Drug Delivery With Carbon-Based Nanomaterials as Versatile Nanocarriers: Progress and Prospects

Debnath

Srivastava

2021

Front. Nanotechnol.

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With growing interest, a large number of researches have been conducted on carbon-based nanomaterials (CBNs). However, their uses are limited due to comprehensive potential environmental and human health effects. It is often confusing for researchers to make an informed choice regarding the versatile carbon-based nanocarrier system and its potential applications. This review has highlighted emerging applications and cutting-edge progress of CBNs in drug delivery. Some critical factors like enzymatic degradation, surface modification, biological interactions, and bio-corona have been discussed here. These factors will help to fabricate CBNs for effective drug delivery. This review also addresses recent advancements in carbon-based target specific and release controlled drug delivery to improve disease treatment. The scientific community has turned their research efforts into the development of novel production methods of CBNs to make their production more attractive to the industrial sector. Due to the nanosize and diversified physical properties, these CBNs have demonstrated distinct biological interaction. Thus long-term preclinical toxicity study is recommended before finally translating to clinical application.

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“…He et al [65], prepared two cationic polymer-derived C-dots (Taea-CD and Cyclen-CD) using the hydrothermal method which has the potential to condense DNA into nanoparticles with a positive charge and provide protection to DNA from degradation. The results showed 2000 times higher transfection efficiency and also showed high serum tolerance and cell viability as compared to commercially available PEI.…”

Section: Cds Efficiency In Gene Deliverymentioning

confidence: 99%

Carbon Dot Nanoparticles: Exploring the Potential Use for Gene Delivery in Ophthalmic Diseases

Biswal

Bhatia

2021

Nanomaterials

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Ocular gene therapy offers significant potential for preventing retinal dystrophy in patients with inherited retinal dystrophies (IRD). Adeno-associated virus (AAV) based gene transfer is the most common and successful gene delivery approach to the eye. These days, many studies are using non-viral nanoparticles (NPs) as an alternative therapeutic option because of their unique properties and biocompatibility. Here, we discuss the potential of carbon dots (CDs), a new type of nanocarrier for gene delivery to the retinal cells. The unique physicochemical properties of CDs (such as optical, electronic, and catalytic) make them suitable for biosensing, imaging, drug, and gene delivery applications. Efficient gene delivery to the retinal cells using CDs depends on various factors, such as photoluminescence, quantum yield, biocompatibility, size, and shape. In this review, we focused on different approaches used to synthesize CDs, classify CDs, various pathways for the intake of gene-loaded carbon nanoparticles inside the cell, and multiple studies that worked on transferring nucleic acid in the eye using CDs.

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Cationic polymer-derived carbon dots for enhanced gene delivery and cell imaging

Abstract: The transformation of cationic polymers derived from ring-opening polymerization to carbon dots was proved as a promising strategy for developing gene vectors with high efficiency and cell-imaging ability.

Cited by 35 publications

References 41 publications

Carbon Dots: Classification, Properties, Synthesis, Characterization, and Applications in Health Care—An Updated Review (2018–2021)

Carbon Dots: Classification, Properties, Synthesis, Characterization, and Applications in Health Care—An Updated Review (2018–2021)

Drug Delivery With Carbon-Based Nanomaterials as Versatile Nanocarriers: Progress and Prospects

Carbon Dot Nanoparticles: Exploring the Potential Use for Gene Delivery in Ophthalmic Diseases

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