Cationic poly(cyclodextrin)/alginate nanocapsules: From design to application as efficient delivery vehicle of 4-hydroxy tamoxifen to podocyte in vitro

Belbekhouche, Sabrina; Oniszczuk, Julie; Pawlak, André; Joukhar, Imane El; Goffin, Angélique; Varrault, Gilles; Sahali, Dil; Carbonnier, Benjamin

doi:10.1016/j.colsurfb.2019.03.060

Cited by 17 publications

(14 citation statements)

References 36 publications

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“…Hydrophobic chemicals 4-hydroxy-tamoxifen was loaded by incubated ethanol solution. The results indicated that the 4-hydroxy-tamoxifen was successfully encapsulated retaining its biologic activity [47]. Likewise, an antibiotic amoxicillin was effectively entrapped into a hollow LBL polyelectrolyte nanocapsules by suspended the formulated nanocapsules in the amoxicillin buffer acetate solution.…”

Section: Layer-by-layer Methodsmentioning

confidence: 98%

“…Moreover, common polysaccharides stated above, poly(cyclodextrin) [47], heparin [48] hyaluronan [49] and also other polysaccharides have been used to prepare nanocapsules as drug carrier for different pharmaceutic applications.…”

Section: Polymeric Shellmentioning

confidence: 99%

“…The materials considered as the template core should be easily removed by mild conditions in order to avoid shell damage. Metallic materials such as iron oxide [78] and gold [33,47] spheres were used as template core and are able to be removed by hydrochloric acid solution or potassium cyanide solution after polysaccharide shell is formed. Calcium carbonate as an inorganic candidate template core of nanocapsules can be removed by adding ethylene diamine tetra acetic acid into a nanocapsule water dispersion at pH 7 [79].…”

Section: Liquid/solid/hollow Corementioning

confidence: 99%

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Polymeric Nanocapsules as Nanotechnological Alternative for Drug Delivery System: Current Status, Challenges and Opportunities

et al. 2020

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Polymer-based nanocapsules have been widely studied as a potential drug delivery system in recent years. Nanocapsules—as one of kind nanoparticle—provide a unique nanostructure, consisting of a liquid/solid core with a polymeric shell. This is of increasing interest in drug delivery applications. In this review, nanocapsules delivery systems studied in last decade are reviewed, along with nanocapsule formulation, characterizations of physical/chemical/biologic properties and applications. Furthermore, the challenges and opportunities of nanocapsules applications are also proposed.

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Section: Layer-by-layer Methodsmentioning

confidence: 98%

Section: Polymeric Shellmentioning

confidence: 99%

Section: Liquid/solid/hollow Corementioning

confidence: 99%

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Polymeric Nanocapsules as Nanotechnological Alternative for Drug Delivery System: Current Status, Challenges and Opportunities

et al. 2020

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“…The self-assembly of amphiphilic polysaccharides in water leads to the formation of various formulations, depending on the content of hydrophobic groups covalently linked to the hydrophilic chain. Amphiphilic polysaccharides can form various structures, i.e., micelles, nanoparticles, microspheres and hydrogels that can carry both hydrophilic and hydrophobic compounds [ 79 , 80 , 81 , 82 , 83 ].…”

Section: Amphiphilic Polymers As Nanoemulsion Stabilizers: From Symentioning

confidence: 99%

Polymer Capsules with Hydrophobic Liquid Cores as Functional Nanocarriers

et al. 2020

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Recent developments in the fabrication of core-shell polymer nanocapsules, as well as their current and future applications, are reported here. Special attention is paid to the newly introduced surfactant-free fabrication method of aqueous dispersions of nanocapsules with hydrophobic liquid cores stabilized by amphiphilic copolymers. Various approaches to the efficient stabilization of such vehicles, tailoring their cores and shells for the fabrication of multifunctional, navigable nanocarriers and/or nanoreactors useful in various fields, are discussed. The emphasis is placed on biomedical applications of polymer nanocapsules, including the delivery of poorly soluble active compounds and contrast agents, as well as their use as theranostic platforms. Other methods of fabrication of polymer-based nanocapsules are briefly presented and compared in the context of their biomedical applications.

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“…In this scenario, branched cationic CD polymers have been designed for several applications. They increase the permeability of drugs to biological membranes [ 28 ], easily self-assemble into optimized nanocontainers for efficient intracellular delivery [ 29 ], form nanoemulsions for oral delivery [ 30 ], or systems for targeting antimicrobial effects in biofilms [ 31 ].…”

Section: Introductionmentioning

confidence: 99%

Cyclodextrin Cationic Polymer-Based Nanoassemblies to Manage Inflammation by Intra-Articular Delivery Strategies

et al. 2020

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Injectable nanobioplatforms capable of locally fighting the inflammation in osteoarticular diseases, by reducing the number of administrations and prolonging the therapeutic effect is highly challenging. β-Cyclodextrin cationic polymers are promising cartilage-penetrating candidates by intra-articular injection due to the high biocompatibility and ability to entrap multiple therapeutic and diagnostic agents, thus monitoring and mitigating inflammation. In this study, nanoassemblies based on poly-β-amino-cyclodextrin (PolyCD) loaded with the non-steroidal anti-inflammatory drug diclofenac (DCF) and linked by supramolecular interactions with a fluorescent probe (adamantanyl-Rhodamine conjugate, Ada-Rhod) were developed to manage inflammation in osteoarticular diseases. PolyCD@Ada-Rhod/DCF supramolecular nanoassemblies were characterized by complementary spectroscopic techniques including UV-Vis, steady-state and time-resolved fluorescence, DLS and ζ-potential measurement. Stability and DCF release kinetics were investigated in medium mimicking the physiological conditions to ensure control over time and efficacy. Biological experiments evidenced the efficient cellular internalization of PolyCD@Ada-Rhod/DCF (within two hours) without significant cytotoxicity in primary human bone marrow-derived mesenchymal stromal cells (hMSCs). Finally, polyCD@Ada-Rhod/DCF significantly suppressed IL-1β production in hMSCs, revealing the anti-inflammatory properties of these nanoassemblies. With these premises, this study might open novel routes to exploit original CD-based nanobiomaterials for the treatment of osteoarticular diseases.

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Cationic poly(cyclodextrin)/alginate nanocapsules: From design to application as efficient delivery vehicle of 4-hydroxy tamoxifen to podocyte in vitro

Cited by 17 publications

References 36 publications

Polymeric Nanocapsules as Nanotechnological Alternative for Drug Delivery System: Current Status, Challenges and Opportunities

Polymeric Nanocapsules as Nanotechnological Alternative for Drug Delivery System: Current Status, Challenges and Opportunities

Polymer Capsules with Hydrophobic Liquid Cores as Functional Nanocarriers

Cyclodextrin Cationic Polymer-Based Nanoassemblies to Manage Inflammation by Intra-Articular Delivery Strategies

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