Cationic Antimicrobial Peptides

Phoenix, David A.; Dennison, Sarah Rachel; Harris, Frederick

doi:10.1002/9783527652853.ch2

Cited by 8 publications

(2 citation statements)

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“…As to why these AHDPs possess the capacity for anticancer activity is unclear as, self-evidently, this capacity has no relevance to plant survival [85]. However, it has been suggested that this anticancer activity may result from the general ability of these peptides to interact with membranes [86], which appears to have evolved to kill microorganisms in line with the role of most HDPs as endogenous antimicrobials [39]. This review has shown that the anticancer actions used by plant AHPDs are based on membrane interaction, which at least in some cases, appears to involve the use of PE as a lipid receptor (Fig.…”

Section: Discussionmentioning

confidence: 99%

“…In this conformation, Cn-AMP2 exhibited a strongly hydrophobic region, formed by the C-terminal eight residues of the peptide, YFVFSVGM, which was flanked by a short anionic segment, TES [36,37]. This residue arrangement endows Cn-AMP2 with primary amphiphilicity [36,37], which has been reported for other anticancer peptides such as indolicidin [38,39] and is known to mediate the ability of these peptides to traverse membranes [40]. By analogy to indolicidin, it was suggested that the ability of Cn-AMP2 to traverse cancer cell membranes may be hydrophobicity driven by a mechanism involving the peptide's C-terminal region [36,37].…”

Section: Please Provide Corresponding Author(s) Photograph Size Shoulmentioning

confidence: 99%

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Anionic Host Defence Peptides from the Plant Kingdom: Their Anticancer Activity and Mechanisms of Action

Harris¹,

Prabhu²,

Dennison³

et al. 2016

PPL

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Abstract:It is becoming increasingly clear that plants ranging across the plant kingdom produce anionic host defence peptides (AHDPs) with potent activity against a wide variety of human cancers cells. In general, this activity involves membrane partitioning by AHDPs, which leads to membranolysis and / or internalization to attack intracellular targets such as DNA. Several models have been proposed to describe these events including: the toroidal pore and Shai-Matsuzaki-Huang mechanisms but, in general, the mechanisms underpinning the membrane interactions and anticancer activity of these peptides are poorly understood. Plant AHDPs with anticancer activity can be conveniently discussed with reference to two groups: cyclotides, which possess cyclic molecules stabilized by cysteine knot motifs, and other ADHPs that adopt extended andhelical conformations. Here, we review research into the anticancer action of these two groups of peptides along with current understanding of the mechanisms underpinning this action.

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Section: Discussionmentioning

confidence: 99%