Cathodic Stripping Voltammetric Determination of Losartan in Bulk and Pharmaceutical Products

Habib, I. H. I.; Weshahy, Soheir A.; Toubar, Safaa S.; El‐Alamin, Maha M. Abou

doi:10.4152/pea.200804315

Cited by 29 publications

(12 citation statements)

References 25 publications

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“…22 On the other hand, the N=N group in most organic compounds is known to be reduced much easier than C=N one. [23][24][25] So, considering the reduction potentials of irbesartan over the entire pH range, the reduction behavior of irbesartan on HMDE may be attributed to saturation of the azomethine group C=N in tetrazolyl moiety of irbesartan molecule 26 not to the N=N group which is in contradictory to that reported in literature.…”

Section: Electroreduction Of Irbesartancontrasting

confidence: 62%

Voltammetry of irbesartan drug in pharmaceutical formulations and human blood: quantification and pharmacokinetic studies

El‐Desoky¹,

Ghoneim²,

Habazy³

2011

J. Braz. Chem. Soc.

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Voltamogramas cíclicos de 'irbesatan' em um eletrodo de gota pendente de mercúrio no tampão Britton-Robinson com valores de pH menores do que 4,5 exibiram um único pico catódico irreversível envolvendo dois elétrons, correspondendo à redução-saturação da ligação dupla C=N de sua unidade tetrazólia. Na faixa de pH 4,5-5,5, os voltamogramas exibiram dois picos catódicos irreversíveis (1º e 2º picos) com corrente de pico menor porém com alturas relativas iguais, as quais foram atribuídas à redução do grupo C=N das formas ácida e básica de 'irbesatan', respectivamente. Um método voltamétrico de onda quadrada com redissolução anódica adsortiva foi desenvolvido para a quantificação de ibsertan total em solução. O método desenvolvido foi aplicado com sucesso na quantificação de 'ibsertan' em formulações farmacêuticas e soro humano enriquecido sem a necessidade de pré-tratamento de amostras e/ou etapas lentas de extração antes da análise. Foram obtidas interferências insignificantes de seu ingrediente ativo "hidroclorotiazida", excipientes, íons metálicos comuns e drogas co-administradas. Limites de detecção de 9,0x10-10 e 2,1x10 -9 mol L -1 e limites de quantificação de 3,0x10 -9 e 7,0x10 -9 mol L -1 de 'irbesartan' total em padrão e em soro humano enriquecido foram alcançadas, respectivamente, pelo método voltamétrico desenvolvido. Além disto, parâmetros fármacocinéticos de 'irbesartan' em plasma de voluntários saudáveis obtidos após a administração oral de uma única dose de tabletes Aprovel® também foram estimados.Cyclic voltammograms of irbesartan at the hanging mercury dropping electrode in the BrittonRobinson buffer of pH values lower than 4.5 exhibited a single 2-electron irreversible cathodic peak corresponding to the reduction-saturation of the C=N double bond of its tetrazolyl moiety. Over the pH range 4.5-5.5, the voltammograms exhibited two irreversible cathodic peaks (1 st and 2 nd peaks) of lower peak current but of relatively equal heights which were attributed to reduction of the C=N group of the acidic and basic forms of irbesartan, respectively. A validated square-wave adsorptive cathodic stripping voltammetric method was developed for quantification of irbesartan in the bulk form. The developed stripping voltammetric method was successfully applied for quantitation of irbesartan in pharmaceutical formulations and spiked human serum, without the necessity for samples pretreatment and/or time-consuming extraction steps prior to the analysis. Insignificant interferences from its active ingredient "hydrochlorothiazide", excipients, common metal ions and co-administrated drugs were obtained during the analysis. Limits of detection of 9.0x10 -10 and 2.1x10 -9 mol L -1 and limits of quantitation of 3.0x10 -9 and 7.0x10 -9 mol L -1 irbesartan in the bulk form and in spiked human serum were achieved, respectively, by the developed stripping voltammetric method. Moreover, pharmacokinetic parameters of irbesartan in plasma of healthy volunteers following an oral administration of a single dose of Aprovel® tablet...

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Section: Electroreduction Of Irbesartancontrasting

confidence: 62%

Voltammetry of irbesartan drug in pharmaceutical formulations and human blood: quantification and pharmacokinetic studies

El‐Desoky¹,

Ghoneim²,

Habazy³

2011

J. Braz. Chem. Soc.

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“…Habib et al [25] described a cathodic stripping voltammetric determination of losartan using hanging mercury drop electrode (HMDE). The method was based on adsorptive accumulation of the species at HMDE and at pH 7, followed by alternating current (AC) sweep.…”

Section: Voltammetric Methodsmentioning

confidence: 99%

Losartan

Al-Majed

Assiri

Khalil

et al. 2015

Profiles of Drug Substances, Excipients and Related Methodology

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“…Potentiometric method offers a simple system and cost effective method than that of other methods which are having high cost, multiple steps and time consuming. Habib et al (2008) reported stripping voltammetry determination of VAL using a Hanging Mercury Drop Electrode (HMDE), was based on adsorptive accumulation of the species at HMDE followed by first harmonic alternating current AC stripping sweep at pH 6, the response was linear over the concentration range of 0.08-0.64 mg/mL with regression coefficient 0.999 [92].…”

Section: Potentiometric Methodsmentioning

confidence: 99%

A Concise Review on Analytical Profile of Valsartan

Shirkhedkar¹,

Chaudhari²,

Patil³

et al. 2017

Eurasian J Anal Chem

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Valsartan (VAL) is an orally active angiotensin-II receptor type-I antagonist. VAL is available alone in dosage form as well as multicomponent formulation with various antihypertensive drugs like nifedipine, hydrochlorothiazide, ramipril, amlodipine and nebivolol hydrochloride, for the management of hypertension. The present investigation assesses the various approaches for analysis of VAL in bulk drug as well as formulated products. A concise review represents the compilation and discussion of about more than 90 analytical methods which includes HPLC, HPTLC, capillary electrophoresis, electrochemical methods and UV-Spectrophotometry methods implemented for investigation of VAL in biological matrices, bulk samples and in different dosage formulations. The review describes the percentage utilization of the various approaches for analysis of VAL. The statistical data regarding the utility of these methods for estimation of VAL published during 2001 to 2016 have been included.

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Cathodic Stripping Voltammetric Determination of Losartan in Bulk and Pharmaceutical Products

Cited by 29 publications

References 25 publications

Voltammetry of irbesartan drug in pharmaceutical formulations and human blood: quantification and pharmacokinetic studies

Voltammetry of irbesartan drug in pharmaceutical formulations and human blood: quantification and pharmacokinetic studies

Losartan

A Concise Review on Analytical Profile of Valsartan

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