Catheter-related candidemia caused by <i>Candida lipolytica</i> in a child with tubercular meningitis

In Vitro Activity of Seven Systemically Active Antifungal Agents against a Large Global Collection of RareCandidaSpecies as Determined by CLSI Broth Microdilution Methods

“…Although rare, infections with this species in two patients with candidemia, three patients with traumatic ocular infections, one patient with chronic sinusitis, and children and adults with catheter-related fungemia have been documented (1,9,23,61,62,107,109). Patients described in the literature have been successfully treated with catheter removal and amphotericin B therapy (1,23), although Belet et al (9) described fungemia due to C. lipolytica that persisted in two infants despite catheter removal and amphotericin B treatment. Both infections resolved following the addition of caspofungin to amphotericin B. Shin et al (93) reported an outbreak of fungemia due to C. lipolytica (n ϭ 5 cases) in a pediatric ward.…”

Yarrowia lipolytica: Safety assessment of an oleaginous yeast with a great industrial potential

“…Since 1985, 55 cases of human infections due to Y. lipolytica have been described (Agarwal et al, 2008;Belet et al, 2006;Blanco et al, 2009;Chang et al, 2001;D'Antonio et al, 2002;Franck et al, 2010;Kang et al, 2008;Ninin et al, 1997;Ö zdemir et al, 2011;Shin et al, 2000;Walsh et al, 1989;Wehrspann & Füllbrandt, 1985;Yoon, 2009). Ninin et al (1997) reported nine cases in their hospital that were isolated within only two years, which may suggest that infections by Y. lipolytica occur more frequently than presently anticipated.…”

“…Six patients infected with Y. lipolytica suffered from diverse forms of leukemia (Chang et al, 2001;D'Antonio et al, 2002;Ninin et al, 1997;Shin et al, 2000;Ye et al, 2011). Other cases where Y. lipolytica infections were diagnosed included a neuroblastoma patient who received high-dose chemotherapy and was highly neutropenic (Ö zdemir et al, 2011), a 5-year-old boy who suffered from aplastic anemia and was immunocompromised because of globulin and cyclosporine therapies (Shin et al, 2000), a newborn treated with broad-spectrum antibiotics who was also co-infected with C. albicans (Belet et al, 2006), a 3-year-old male with tubercular meningitis who also received broad spectrum antibiotics (Agarwal et al, 2008), a 2-monthold boy with streptococcal meningitis (Shin et al, 2000) and a 4-month-old malnourished girl who received parenteral nutrition, was treated with vancomycin and later received broad spectrum antibiotics, and was also infected with C. albicans isolated from blood and the catheter. One case occurred in an 86-year-old female who suffered from many disorders, such as arterial hypertension, diabetes mellitus type 2, vesical neoformation with peritoneal fibrosis, bilateral hydronephrosis and recurrent urinary tract infections by many bacterial and yeast species other than Y. lipolytica (Blanco et al, 2009).…”

Clinical Characteristics, Laboratory Identification, and In Vitro Antifungal Susceptibility of Yarrowia (Candida) lipolytica Isolates Causing Fungemia: a Multicenter, Prospective Surveillance Study

“…Other forms of clinical disease, including noncatheter-related fungemia, traumatic ocular infection, and acute exacerbation of chronic sinusitis, have also been reported (5, 8, 11). A major limitation of the literature on Y. lipolytica infection is that most studies were case reports or small case series focusing only on clinical characteristics (5,(8)(9)(10)(11)(12)(13)(14)(15)(16)(17). Recently, Trabelsi and colleagues reported the epidemiological risk factors and clinical outcomes of 55 cases of Y. lipolytica fungemia in Tunisia and provided some data on the in vitro susceptibility test results of the isolates to a few antifungal drugs (6).…”