Catheter-related bacteremia due to Chryseobacterium indologenes in a bone marrow transplant recipient

Akay, Meltem Olga; Gündüz, Eren; Gülbaş, Zafer

doi:10.1038/sj.bmt.1705261

Cited by 19 publications

(22 citation statements)

References 10 publications

(9 reference statements)

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“…Clones from coral sample 2 showed sequence identity to a large number of bacteria that are reported in degradation of pesticides, herbicides and insecticides (Martin et al 1999;Kumar and Philip 2006). Clones HKT72, 78 and 91 were identified by BLAST as uncultured Chryseobacterium reported in diseased aquatic animals and hospital wastes (Bernardet et al 2005;Akay et al 2006). The phylogenetic tree of bacteria associated with coral sample 2 is shown in Fig.…”

Section: Measures Of Evennessmentioning

confidence: 98%

Preliminary analysis of bacterial diversity associated with the Porites coral from the Arabian sea

Kapley

Siddiqui

Misra

et al. 2007

World J Microbiol Biotechnol

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It is widely reported that coral reefs are suffering degradation from a combination of stresses. We have previously reported the use of genomic tools in the study of environmental impact assessment and hypothesize that monitoring the bacterial diversity associated with a coral would indicate changes in its health before visible damage occurs. This study analyzes the bacterial diversity associated with Porites coral collected from two sites in the Arabian Sea using culture independent techniques. Two clone libraries were constructed from the16S rDNA amplicons and selected individual clones were partially sequenced. Retrieved sequences were identified by BLAST analysis and indicate the presence of unidentified bacteria. Diversity index was calculated using Shannon-Wiener index. The bacterial diversity associated with coral sample 1 gives the index of species diversity, H 1 as 1.6287, divergence from eqiprobability as 45.708% and the evenness of the sample as 54.291. For coral sample 2, the values obtained were, H 1 as 1.97, divergence from eqiprobability as 15.11% and the evenness of the sample as 84.88. Sequences representing bacteria related to agricultural or industrial pollution and pathogenesis were also found. Coral samples collected near a lagoon area, showed a greater percentage of sequences representing bacteria related to human interventions, indicative of pollution.

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Section: Measures Of Evennessmentioning

confidence: 98%

Preliminary analysis of bacterial diversity associated with the Porites coral from the Arabian sea

Kapley

Siddiqui

Misra

et al. 2007

World J Microbiol Biotechnol

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“…Although their overall clinical impact is lower than that of Enterobacteriaceae, Pseudomonas, or Acinetobacter species, Flavobacteriaceae may cause various clinical syndromes that are not always straightforward to treat, due mainly to their intrinsic resistance to several antimicrobial agents (29). Eight different sublineages of resident enzymes in members of the family Flavobacteriaceae have been identified thus far (4-7, 18, 20, 26), and most of them (BlaB from Elizabethkingia meningoseptica, IND from Chryseobacterium indologenes, JOHN from Flavobacterium johnsoniae, CGB from Chryseobacterium gleum, EBR from Empedobacter brevis, TUS from Myroides odoratus, and MUS from Myroides odoratimimus) belong to subclass B1, although the GOB enzymes (from E. meningoseptica) belong to subclass B3.The most common flavobacterium from clinical specimens is C. indologenes, which is associated with different types of infections, such as intra-abdominal and urinary tract infections, catheter-related bacteremia, cellulitis, sepsis, and pneumonia, likely promoted by the bacterium's ability to form biofilm and to produce proteases (1,3,15,16,21,23,24,33). In some nosocomial settings, C. indologenes infections were also associated with relatively high mortality rates (16).…”

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confidence: 99%

“…The most common flavobacterium from clinical specimens is C. indologenes, which is associated with different types of infections, such as intra-abdominal and urinary tract infections, catheter-related bacteremia, cellulitis, sepsis, and pneumonia, likely promoted by the bacterium's ability to form biofilm and to produce proteases (1,3,15,16,21,23,24,33). In some nosocomial settings, C. indologenes infections were also associated with relatively high mortality rates (16).…”

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confidence: 99%

IND-6, a Highly Divergent IND-Type Metallo-β-Lactamase fromChryseobacterium indologenesStrain 597 Isolated in Burkina Faso

Zeba

Luca

Dubus

et al. 2009

Antimicrob Agents Chemother

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The genus Chryseobacterium and other genera belonging to the family Flavobacteriaceae include organisms that can behave as human pathogens and are known to cause different kinds of infections. Several species of Flavobacteriaceae, including Chryseobacterium indologenes, are naturally resistant to ␤-lactam antibiotics (including carbapenems), due to the production of a resident metallo-␤-lactamase. Although C. indologenes presently constitutes a limited clinical threat, the incidence of infections caused by this organism is increasing in some settings, where isolates that exhibit multidrug resistance phenotypes (including resistance to aminoglycosides and quinolones) have been detected. Here, we report the identification and characterization of a new IND-type variant from a C. indologenes isolate from Burkina Faso that is resistant to ␤-lactams and aminoglycosides Metallo-␤-lactamases (MBLs) belong to Ambler's class B, and their activity requires at least one zinc ion in the active site. These enzymes are particularly worrisome resistance determinants due to their ability to hydrolyze most ␤-lactam compounds, including carbapenems, while they are not susceptible to conventional ␤-lactamase inhibitors (e.g., clavulanic acid, sulbactam, and tazobactam) (25). Besides the acquired MBL genes which currently disseminate in major human pathogens (e.g., Pseudomonas aeruginosa) by means of mobile genetic elements (plasmids, integrons, or ISCR elements), most MBL genes identified thus far have been found in the chromosomes of various bacterial species, including nonpathogenic organisms (such as Caulobacter crescentus), plant pathogens (Erwinia carotovora), and occasional human pathogens such as Stenotrophomonas maltophilia, Aeromonas spp., and members of the family Flavobacteriaceae (25, 32). The latter family includes several species in which the production of a resident MBL has been detected. Although their overall clinical impact is lower than that of Enterobacteriaceae, Pseudomonas, or Acinetobacter species, Flavobacteriaceae may cause various clinical syndromes that are not always straightforward to treat, due mainly to their intrinsic resistance to several antimicrobial agents (29). Eight different sublineages of resident enzymes in members of the family Flavobacteriaceae have been identified thus far (4-7, 18, 20, 26), and most of them (BlaB from Elizabethkingia meningoseptica, IND from Chryseobacterium indologenes, JOHN from Flavobacterium johnsoniae, CGB from Chryseobacterium gleum, EBR from Empedobacter brevis, TUS from Myroides odoratus, and MUS from Myroides odoratimimus) belong to subclass B1, although the GOB enzymes (from E. meningoseptica) belong to subclass B3.The most common flavobacterium from clinical specimens is C. indologenes, which is associated with different types of infections, such as intra-abdominal and urinary tract infections, catheter-related bacteremia, cellulitis, sepsis, and pneumonia, likely promoted by the bacterium's ability to form biofilm and to produce proteases (1,3,15,16,21,23,24...

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“…C indologenes has been reported to cause primary bacteraemia,9 13 catheter-related bacteraemia,7 10 11 15 wound sepsis,13 16 cellulitis,17 pyelonephritis,13 peritonitis,13 biliary tract infection,13 urinary tract infection,18 pneumonia13 14 and keratitis of the eye 19. Infections caused by all Chryseobacterium species combined represent only 0.03% of all bacterial isolates collected by the SENTRY Program during the 5-year period evaluated (1997–2001) with about 40% due to C indologenes 20.…”

Section: Discussionmentioning

confidence: 99%

Chryseobacterium indologenesperitonitis in peritoneal dialysis

Afshar

Nobakht

Lew³

2013

BMJ Case Reports

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Peritoneal dialysis-related peritonitis remains a major complication of peritoneal dialysis in patients with end-stage renal disease. Chryseobacterium indologenes is a rare organism that has been reported to cause infections mostly in hospitalised patients with severe underlying diseases. We report the first case of C indologenes peritonitis in a patient on peritoneal dialysis outside of Asia. Our patient with end-stage renal disease on peritoneal dialysis grew C indologenes from peritoneal fluid when he presented with abdominal pain and cloudy effluent. The patient responded well to intraperitoneal antibiotic therapy. Tenckhoff catheter did not require removal. This case demonstrates the importance of considering rare causes of peritonitis, such as C indologenes, in patients on peritoneal dialysis. Given the resistance of such organisms to commonly used broad-spectrum antibiotics, antimicrobial susceptibility testing must be assessed as early as possible to assure appropriate antibiotic coverage to avoid untreated peritonitis leading to peritoneal dialysis failure.

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Catheter-related bacteremia due to Chryseobacterium indologenes in a bone marrow transplant recipient

Cited by 19 publications

References 10 publications

Preliminary analysis of bacterial diversity associated with the Porites coral from the Arabian sea

Preliminary analysis of bacterial diversity associated with the Porites coral from the Arabian sea

IND-6, a Highly Divergent IND-Type Metallo-β-Lactamase fromChryseobacterium indologenesStrain 597 Isolated in Burkina Faso

Chryseobacterium indologenesperitonitis in peritoneal dialysis

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