Catheter-directed Thrombolysis in Deep Venous Thrombosis with Use of Reteplase: Immediate Results and Complications from a Pilot Study

Castañeda, Flavio; Li, Ruizong; Young, Kate; Swischuk, James L.; Smouse, Bob; Brady, Terry M.

doi:10.1016/s1051-0443(07)61650-9

Cited by 67 publications

(18 citation statements)

References 9 publications

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“…While evidence from observational studies [62][63][64][65] and one RCT 66 supports catheter-directed thrombolysis for isolated lower extremity DVT [66][67][68][69] and combined upper and lower extremity DVT, 62 evidence in support of catheter-directed thrombolysis for PE is limited. One case report 67 and a case series 68 of 13 postoperative patients, treated with reduced dose urokinase and heparin titrated to fibrinogen, describe successful catheter-directed thrombolysis for PE.…”

Section: Catheter-directed Thrombolysismentioning

confidence: 99%

A critical review of thromboembolic complications associated with central venous catheters

Burns

McLaren

2008

Can J Anesth/J Can Anesth

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Purpose: Central venous catheters (CVC) are commonly used in critical care. While thrombosis is a well-recognized and frequent complication associated with their use, CVC-related thromboembolic complications, including pulmonary embolism (PE) and right heart thromboembolism (RHTE), occur less frequently and often evade diagnosis. Little information exists to guide clinicians in the diagnosis and management of CVC-related thromboembolic complications. Source:We critically review and synthesize the literature highlighting the incidence of CVC-related thrombosis. We highlight the risk for developing thromboembolic complications and provide approaches to diagnosing and managing RHTE. Principle findings:The incidence of CVC-related thrombosis varies depending on patient, site, instrument, and infusaterelated factors. Central venous catheters-related thrombosis represents an important source of morbidity and mortality for affected patients. Pulmonary embolism occurs in approximately 15% of patients with CVC-related upper extremity deep venous thrombosis (UEDVT). More frequent use of transesophageal echocardiography, in patients with suspected and confirmed PE, has resulted in increased detection of RHTE. While it is recognized that the occurrence of RHTE, in association with PE, increases mortality, the optimal strategy for their management has not been established in a clinical trial. Conclusion:Central venous catheter-related thrombosis occurs frequently and represents an important source of morbidity and mortality for affected patients. Our review supports that surgery and thrombolysis have both been demonstrated to enhance survival in patients with RHTE and PE. However, important patient, clot, and institutional considerations mandate that treatment for patients with RHTE and PE be individualized.

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Section: Catheter-directed Thrombolysismentioning

confidence: 99%

A critical review of thromboembolic complications associated with central venous catheters

Burns

McLaren

2008

Can J Anesth/J Can Anesth

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“…[1][2][3] The treatment goals in lower extremity DVT are to prevent the embolic potential of existing thrombus burden, restore unobstructed flow, prevent recurrence, and preserve venous valve function. Traditionally, the treatment for DVT has been systemic anticoagulation; however, previous studies have shown catheter-directed thrombolysis to have superior results with success rates of over 90%, 4,5 with 79% of completely lysed vessels remaining patent at 1 year. 6 To date, the published data regarding peripheral vascular thrombolysis are difficult to interpret because of the lack of unified adherence to reporting standards and non-standard institutionalspecific dosing protocols.…”

Section: Introductionmentioning

confidence: 99%

The Association of Periprocedural Hypertension and Adverse Outcomes in Patients Undergoing Catheter-Directed Thrombolysis

Agle

McNally

Powell

et al. 2010

Annals of Vascular Surgery

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“…Most other studies of catheter-directed thrombolysis are observational studies or case series. [68][69][70][71][72][73][74][75][76][77] While these studies suggest that catheter-directed thrombolysis may be effi cacious in well-chosen patients, the evidence is insuffi cient to make recommendations.…”

mentioning

confidence: 99%

Management of Venous Thromboembolism: A Clinical Practice Guideline from the American College of Physicians and the American Academy of Family Physicians

Snow

Qaseem

Barry³

et al. 2007

The Annals of Family Medicine

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Catheter-directed Thrombolysis in Deep Venous Thrombosis with Use of Reteplase: Immediate Results and Complications from a Pilot Study

Cited by 67 publications

References 9 publications

A critical review of thromboembolic complications associated with central venous catheters

A critical review of thromboembolic complications associated with central venous catheters

The Association of Periprocedural Hypertension and Adverse Outcomes in Patients Undergoing Catheter-Directed Thrombolysis

Management of Venous Thromboembolism: A Clinical Practice Guideline from the American College of Physicians and the American Academy of Family Physicians

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