Catheter Ablation of Persistent Atrial Fibrillation

Rajappan, Kim; Ginks, Matthew

doi:10.2217/fca.14.40

Cited by 3 publications

(3 citation statements)

References 56 publications

(40 reference statements)

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“…This procedure involves many different variations and anatomic approaches but commonly relies on introducing a catheter with an electrode tip threaded to the heart atrium from the groin or the internal jugular vein and destroying by freezing or heating, the venous or heart tissue that is the source of electrical irritability causing AF. [85] 11 Catheter ablation for persistent AF is a realtively safe procedure and is reputed to have a 95% success rate patients experiencing significant improvement of their AF over a 6…”

Section: Atrial Fibrillationmentioning

confidence: 99%

Cerebral Perfusion Enhancing Interventions: A New Strategy for the Prevention of Alzheimer Dementia

Torre

2016

Brain Pathology

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Cardiovascular and cerebrovascular diseases are major risk factors in the development of cognitive impairment and Alzheimer's disease (AD). These cardio-cerebral disorders promote a variety of vascular risk factors which in the presence of advancing age are prone to markedly reduce cerebral perfusion and create a neuronal energy crisis. Long-term hypoperfusion of the brain evolves mainly from cardiac structural pathology and brain vascular insufficiency. Brain hypoperfusion in the elderly is strongly associated with the development of mild cognitive impairment (MCI) and both conditions are presumed to be precursors of Alzheimer dementia. A therapeutic target to prevent or treat MCI and consequently reduce the incidence of AD aims to elevate cerebral perfusion using novel pharmacological agents. As reviewed here, the experimental pharmaca include the use of Rho kinase inhibitors, neurometabolic energy boosters, sirtuins and vascular growth factors. In addition, a compelling new technique in laser medicine called photobiomodulation is reviewed. Photobiomodulation is based on the use of low level laser therapy to stimulate mitochondrial energy production non-invasively in nerve cells. The use of novel pharmaca and photobiomodulation may become important tools in the treatment or prevention of cognitive decline that can lead to dementia.

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Section: Atrial Fibrillationmentioning

confidence: 99%

Cerebral Perfusion Enhancing Interventions: A New Strategy for the Prevention of Alzheimer Dementia

Torre

2016

Brain Pathology

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“…However, the high recurrence rate hinders its application and remains an important problem that needs to be addressed. 3 Recently, a number of studies have shown that inflammation and oxidative stress are associated with the development of AF and indicated that there is a positive association between C-reactive protein levels and AF recurrence. 4 This means that statins, the antiinflammatory medications, may have a positive role in the prevention of AF.…”

Section: Introductionmentioning

confidence: 99%

“…Currently, catheter ablation is considered to be one of most effective treatments of AF. However, the high recurrence rate hinders its application and remains an important problem that needs to be addressed . Recently, a number of studies have shown that inflammation and oxidative stress are associated with the development of AF and indicated that there is a positive association between C‐reactive protein levels and AF recurrence .…”

Section: Introductionmentioning

confidence: 99%