“…To diagnose dry eye disease (DED), the cut-off values used were an OSDI score ≥ 13, tear osmolarity ≥ 308 mOsm/L, FBUT < 10 s, and corneal staining (Oxford Scheme) ≥ 2 (Table 1). Only participants who were classi ed as having DED, with positive symptomatology and positive results on at least one clinical test, were included in the study sample [7,13,14]. According to the TFOS DEWS II criteria [7,8], participants were classi ed as having aqueous-de cient DED (ADDE) if they obtained a low tear meniscus height (TMH ≤ 20mm), as having evaporative DED (EDE) if they obtained a thin lipid layer pattern (LLP ≤ CM), or as having mixed DED if both criteria were met [8, 15,16].…”