Catecholamines and their metabolites

K»gedal, Bertil; Goldstein, David S.

doi:10.1016/s0378-4347(00)83871-2

Cited by 167 publications

(52 citation statements)

References 288 publications

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“…VMA in urine was measured by HPLC with fluorometric detection. Here, the inter-assay CVs ranged from 2.4 to 9.1% with also slightly lower values for the intra-assay CV (19,20). The levels above which the 24-h urinary excretion of catecholamines was determined to be increased were: epinephrine, 0.16 mmol/24 h (29 mg/24 h); norepinephrine, 0.47 mmol/24 h (80 mg/24 h); dopamine, 3.40 mmol/24 h (520 mg/24 h); VMA, 30 mmol/24 h (6 mg/24 h).…”

Section: Methodsmentioning

confidence: 75%

Increased prevalence of catecholamine excess and phaeochromocytomas in a well-defined Dutch population with SDHD-linked head and neck paragangliomas

Houtum¹,

Corssmit²,

Dekker³

et al. 2005

eur j endocrinol

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Objective: The aim of this study was to identify the prevalence of catecholamine excess and phaeochromocytomas in a well-defined population of people with hereditary head and neck paragangliomas. Methods: We studied in a prospective follow-up protocol all consecutive patients referred to the Department of Endocrinology, Leiden University Medical Center, Leiden, The Netherlands with documented head and neck paragangliomas and either a positive family history for paragangliomas or a proven SDHD gene mutation. Initial analysis included medical history, physical examination and the measurement of excretion of catecholamines in two 24-h urine collections. In the case of documented catecholamine excess iodinated meta-iodobenzylguanidine ( 123 I-MIBG) scintigraphy and magnetic resonance imaging were done. Results: Between 1988 and 2003, 40 consecutive patients (20 male and 20 female) with documented head and neck paragangliomas were screened. Biochemical screening revealed urinary catecholamine excess in 15 patients (37.5%). In nine of these 15 patients a lesion was found by 123 I-MIBG scintigraphy. Exact localization by magnetic resonance imaging revealed phaeochromocytomas in seven of the 15 patients. One of the nine patients had an extra-adrenal paraganglioma. Histopathological examination in a subset of tumors displayed loss of heterozygosity of the wild-type SDHD allele in all cases. Conclusions: The prevalence of catecholamine excess (37.5%) and phaeochromocytomas (20.0%) is high in patients with familial head and neck paragangliomas. Therefore, patients with hereditary head and neck paragangliomas require lifelong follow up by biochemical testing for catecholamine excess.European Journal of Endocrinology 152 87-94

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Section: Methodsmentioning

confidence: 75%

Increased prevalence of catecholamine excess and phaeochromocytomas in a well-defined Dutch population with SDHD-linked head and neck paragangliomas

Houtum¹,

Corssmit²,

Dekker³

et al. 2005

eur j endocrinol

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“…It is not surprising, therefore, to find it in biological fluids, despite a strict washout in the dietary protocol. In fact, homovanillic acid, one of the main metabolites of dopamine, has also been reported as a major metabolite of Ht (30,31 ). These observations also raise questions concerning the extent HT from the diet and dihydroxyphenylethanol from dopamine metabolism may participate jointly as an antioxidant system in the body.…”

Section: Discussionmentioning

confidence: 99%

Hydroxytyrosol Disposition in Humans

Covas²,

et al. 2003

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Background: Animal and in vitro studies suggest that phenolic compounds in virgin olive oil are effective antioxidants. In animal and in vitro studies, hydroxytyrosol and its metabolites have been shown to be strong antioxidants. One of the prerequisites to assess their in vivo physiologic significance is to determine their presence in human plasma. Methods: We developed an analytical method for both hydroxytyrosol and 3-O-methyl-hydroxytyrosol in plasma. The administered dose of phenolic compounds was estimated from methanolic extracts of virgin olive oil after subjecting them to different hydrolytic treatments. Plasma and urine samples were collected from 0 to 12 h before and after 25 mL of virgin olive oil intake, a dose close to that used as daily intake in Mediterranean countries. Samples were analyzed by capillary gas chromatography-mass spectrometry before and after being subjected to acidic and enzymatic hydrolytic treatments. Results: Calibration curves were linear (r >0.99). Analytical recoveries were 42-60%. Limits of quantification were <1.5 mg/L. Plasma hydroxytyrosol and 3-O-methyl-hydroxytyrosol increased as a response to virgin olive oil administration, reaching maximum concentrations at 32 and 53 min, respectively (P <0.001 for quadratic trend). The estimated hydroxytyrosol elimination halflife was 2.43 h. Free forms of these phenolic compounds were not detected in plasma samples. Conclusions: The proposed analytical method permits quantification of hydroxytyrosol and 3-O-methyl-hydroxytyrosol in plasma after real-life doses of virgin olive oil. From our results, ϳ98% of hydroxytyrosol appears to be present in plasma and urine in conjugated

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“…LF = Low frequency ; HF = High frequency. (*= control baseline vs T2DM baseline; # = control after 3 months vs T2DM after 3 months) *= p <0.01; **= p <0.001;#= p <0.01;##= p <0.001); n = number of subjects, VMA = Vanillyl mandelic acid Literature review showed that urinary VMA is one of the end product of metabolic degradation of catecholamines in circulation 32 . Its urinary excretion is a measure of sympathetic activity which cause release of catecholamines in circulation [32][33] .…”

Section: Discussionmentioning

confidence: 99%

“…(*= control baseline vs T2DM baseline; # = control after 3 months vs T2DM after 3 months) *= p <0.01; **= p <0.001;#= p <0.01;##= p <0.001); n = number of subjects, VMA = Vanillyl mandelic acid Literature review showed that urinary VMA is one of the end product of metabolic degradation of catecholamines in circulation 32 . Its urinary excretion is a measure of sympathetic activity which cause release of catecholamines in circulation [32][33] . Urinary level of VMA in all diabetic patients showed significantly higher level than nondiabetic control group before intervention but this result after intervention did not reflect any significant variation than their corresponding pre-intervention value.…”

Section: Discussionmentioning

confidence: 99%

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Effect of supine rest on cardiac autonomic tone in type 2 diabetes mellitus

Rahman

Ferdousi

2018

J Bangladesh Soc Physiol

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Background: Autonomic nerve dysfunction has been noted in type 2 diabetes mellitus (T2DM). Regular practice of supine rest (SR) may cause improvement of this impaired autonomic nerve function.Objective: To observe the effect of SR on the autonomic nerve activity by analysis of heart rate variability (HRV) in patients with T2DM.Methods: This prospective interventional study was carried out in the Department of Physiology, Bangabandhu Sheikh Mujib Medical University (BSMMU)during 2016 on 30 female diagnosed T2DM patients aged 50-55 years with duration of diabetes of 5-10 years. They performed SR (20 minutes twice daily) for 3 months. The diagnosed patients were selected from the Out Patient Department of Endocrinology, BSMMU, Dhaka. Thirty age matched apparently healthy females who did not perform regular SR, were control. To assess the cardiac autonomic nerve function, HRV parameters of all subjects were recorded by PowerLab. HRV data of all subjects were collected at baseline and also after 3 months follow-up. In addition, urinary level of Vanillyl Mandelic acid (VMA) of all subjects were measured at baseline and at post intervention period for patients. For statistical analysis, paired and independent sample t-tests were done, as applicable.Results: The pre-intervention values of LF normalized unit (LF nu), LF/HF ratio(p<0.01) and urinary VMA were significantly higher(p <0.001) and HF normalized unit (HF nu) was significantly (p<0.01)lower in all diabetic patients compared to control. The post-intervention data showed LF nu, LF/HF ratio and urinary VMA were reduced and HF nu was increased but these changes were not statistically significant (p> 0.05) in diabetic patients.Conclusion: This study concluded that parasympathetic activity decreased, increased sympathetic activity with higher sympathovagal balance indicating autonomic dysfunction in patients with T2DM, which was shown with trend of improvement after regular practice of supine rest of 3 months though statistically not significant.Bangladesh Soc Physiol. 2017, December; 12(2): 65-71

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Catecholamines and their metabolites

Cited by 167 publications

References 288 publications

Increased prevalence of catecholamine excess and phaeochromocytomas in a well-defined Dutch population with SDHD-linked head and neck paragangliomas

Increased prevalence of catecholamine excess and phaeochromocytomas in a well-defined Dutch population with SDHD-linked head and neck paragangliomas

Hydroxytyrosol Disposition in Humans

Effect of supine rest on cardiac autonomic tone in type 2 diabetes mellitus

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