Amaranthus tricolor whole plants are used by folk medicinal practitioners of Bangladesh for treatment of pain, anaemia, dysentery, skin diseases, diabetes, and as a blood purifier. Thus far, no scientific studies have evaluated the antihyperglycaemic and antinociceptive effects of the plant. The present study was carried out to evaluate the possible glucose tolerance efficacy of methanolic extracts of A. tricolour whole plants using glucose-induced hyperglycaemic mice, and antinociceptive effects with acetic acid-induced gastric pain models in mice. In antihyperglycaemic activity tests, the extract at different doses was administered one hour prior to glucose administration and blood glucose level was measured after two hours of glucose administration (p.o.) using glucose oxidase method. The statistical data indicated the significant oral hypoglycaemic activity on glucose-loaded mice at all doses of the extracts tested. Maximum antihyperglycaemic activity was shown at 400 mg extract per kg body weight, which was comparable to that of a standard drug, glibenclamide (10 mg/kg body weight). In antinociceptive activity tests, the extract also demonstrated a dose-dependent significant reduction in the number of writhings induced in mice through intraperitoneal administration of acetic acid. Maximum antinociceptive activity was observed at a dose of 400 mg extract per kg body weight, which compared favourably with that of a standard antinociceptive drug, aspirin, when administered at a dose of 200 mg per kg body weight. The results validate the folk medicinal use of the plant for reduction of blood sugar in diabetic patients as well as the folk medicinal use for alleviation of pain. The results suggest that this plant may possess further potential for scientific studies leading to possible discovery of efficacious antihyperglycaemic and antinociceptive components.
Chip seal is a widely used preventive maintenance treatment for flexible pavements. However, a major problem with chip seal is the damage caused by loose aggregates from newly placed seals, partly because of a lack of compatibility between aggregate and asphalt emulsion. In this study, limestone, crushed gravel, synthetic lightweight aggregates, and recycled asphalt pavement materials were studied in the laboratory with two polymer-modified asphalt emulsions to find the aggregate–emulsion combination that would result in maximum chip retention. Replicate specimens were tested in the ASTM D7000 sweep test for each aggregate–emulsion combination. Lightweight aggregates and gravel were also tested in a newly developed test setup for simulating the sweep test. Test results show that lightweight aggregates perform better than gravel. However, lightweight aggregate sources play an important role in chip retention. Emulsion is the most significant factor that affects chip loss. Statistical analysis identified the influential design factors affecting chip retention. Analysis of variance shows that aggregate and emulsion types and aggregate–emulsion interaction are significant factors affecting chip retention. Aggregate precoating and its interaction with emulsion type are insignificant factors as far as chip retention is concerned.
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