Catecholamine metabolism of manic-depressive illness

Takahashi, Ryo; Nagao, Yoshiko; Tsuchiya, Kenji J.; Takamizawa, M.; Kobayashi, Tsunetoshi; Toru, Michio; Kobayashi, Kenichi; Kariya, Tetsuhiko

doi:10.1016/0022-3956(68)90050-2

Cited by 25 publications

(2 citation statements)

References 20 publications

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“…The catecholamine hypothesis of affective disorders is that some, if not all, depressions are associated with an absolute or relative decrease in catecholamines, available at central adrenergic receptors sites, while elation, conversely, may be associated with an excess of such amines (4,5). Associated with this hypothesis has been the proposal by one of the present authors (T.F.)…”

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confidence: 65%

Effects of Rubidium on Behavioral Responses to Methamphetamine and Tetrabenazine

Furukawa

Tokuda

1976

Japanese Journal of Pharmacology

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Abstract-Different groups of mice were injected subcutaneoLisly every other day with rubidium chloride at three doses (0.41(50), 1.23(150) and 3.69(450) meq,'kg (mg/kg)) or with saline as a control for a period of 2-3 weeks. Rubidium administered acutely did not affect spontaneous locomotor activities, while it tended to increase the activities when administered repeatedly though the increase was not statistically significant. The methamphetamine-induced hyperlocomotor activities were potentiated in the rubidium groups as compared with those in the saline group, this effect of rubidium being in creased with prolongation of repeated administrations. Monotonic decreases in ambu lation after tetrabenazine were not significantly affected in the rubidium-treated animals though the decreases were sometimes preceded by slight increases and recovery from the decrement tended to be more rapid. After tetrabenazine in the rubidium-treated groups, incidences of catalepsy were increased and jumping behavior and Straub tail responses occurred in a few cases. The results suggest that rubidium potentiates the excitatory action of methamphetamine on spontaneous locomotor activities, as con trasted with inhibitory influence of lithium.Rubidium and lithium, alkaline metals, have been proposed to have valuable therapeutic and prophylactic effects in manic-depressive psychosis; rubidium is principally effective in depressive states (1, 2) while lithium is effective mainly for manic states. In studies on ani mals, the behavioral activation caused by morphine is potentiated by rubidium in mice whereas it is antagonized by lithium (3). Thus rubidium and lithium presumably have opposite effects in all species.Many studies have also been done on the neurochemical mechanisms underlying the affective disorders. The catecholamine hypothesis of affective disorders is that some, if not all, depressions are associated with an absolute or relative decrease in catecholamines, available at central adrenergic receptors sites, while elation, conversely, may be associated with an excess of such amines (4, 5). Associated with this hypothesis has been the proposal by one of the present authors (T.F.) that lithium modifies behavioral responses to me thamphetamine and tetrabenazine and that these drugs act on the metabolism of endogenous brain catecholamines, inhibiting in particular the methamphetamine-induced excitation (6).The present investigation was an attempt to study the effects of rubidium on behavioral responses induced by methamphetamine and tetrabenazine. MATERIALS AND METHODSHealthy ddY male albino mice obtained from the Kuroda Animal Laboratory (Kuma

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confidence: 65%

Effects of Rubidium on Behavioral Responses to Methamphetamine and Tetrabenazine

Furukawa

Tokuda

1976

Japanese Journal of Pharmacology

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“…Many reports have been published of women with premenstrual tension, depression during pregnancy and depression while receiving oral contraceptives who have improved dramatically when given pyridoxine {Baumblatt and Win ston, 1970;Takahashi et al, 1968;Winston 1969a, b). However, Stokes and Mendels (1972) found that 3 women with depression and premenstrual tension improved with the administration of 50 mg of pyridoxine while a placebocontrolled study was equivocal leading to the conclusion that there may be a pyridoxine-responsive group of depression.…”

Section: Pyridoxinementioning

confidence: 99%

Treatment of Intractable Depression

Ananth¹,

Ruskin²

1974

Int Pharmacopsychiatry

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Depression is a frequently encountered psychiatric disorder. Current methods of treatment of these syndromes range from psychotherapy, pharmacotherapy, electroconvulsive therapy and in severe refractory cases, lobotomy. Despite the usefulness of all these methods, 10-28 % of the depressed patients remain refractory to treatment (Bratfos and Haug, 1968; Greenblatt et al, 1964; Smith et al, 1969). As suicide is a relatively high risk in depressed patients, refractory patients may run even higher risk. Hence, various workers have attempted to enhance the antidepressant effects of medications by different techniques. As the basis of all these techniques remain hypothetical at this time, the conclusive evidence of the effectiveness of these methods can come from the clinical application of these techniques by the physicians in treating their intractable, depressed patients.

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The "Switch Process" in Manic-Depressive Illness

Bunney¹

1972

Arch Gen Psychiatry

152

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Catecholamine metabolism of manic-depressive illness

Cited by 25 publications

References 20 publications

Effects of Rubidium on Behavioral Responses to Methamphetamine and Tetrabenazine

Effects of Rubidium on Behavioral Responses to Methamphetamine and Tetrabenazine

Treatment of Intractable Depression

The "Switch Process" in Manic-Depressive Illness

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