Catecholamine binding and concentrations in acute phase plasma after surgery

Sager, Georg; Trovik, T.; Slørdal, Lars; Jaeger, Ragnhild; Prytz, Per S.; Brox, Jan; Reikerås, Olav

doi:10.1080/00365518809085751

Cited by 25 publications

(16 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This explains why neither the quantitative changes (reduced HSA in Type I and increased AAG in Type II) nor the qualitative changes due to glycosylation, are expressed as changes in total plasma protein binding. In the present situation, catecholamine binding was correlated with that of HSA in contrast in acute phase plasma where changes in binding and AAG-concentrations parallelled [16].…”

Section: Discussionmentioning

confidence: 54%

Plasma protein binding of catecholamines, prazosin and propranolol in diabetes mellitus

Trovik

Jaeger

Jorde

et al. 1992

Eur J Clin Pharmacol

Self Cite

View full text Add to dashboard Cite

In the present study equilibrium dialysis has been used to determine the degree of protein binding of the catecholamines adrenaline and noradrenaline and the adrenergic receptor blockers, prazosin and propranolol in diabetics. The binding of the catecholamines in plasma from Type I and II diabetic patients was not significantly different from that of healthy subjects. The ratio of the bound and free catecholamine concentrations was correlated with the level of albumin (HSA). Significantly reduced protein binding of prazosin was observed in Type I and II diabetic subjects compared to healthy volunteers. The binding of propranolol was significantly reduced in Type I patients. The ratios between the bound and unbound concentrations of prazosin and propranolol were significantly correlated with the levels of alpha 1-acid glycoprotein (AAG). The results suggest that non-enzymatic glycosylation of plasma proteins may increase the unbound fraction of the adrenergic blockers prazosin and propranolol.

show abstract

Section: Discussionmentioning

confidence: 54%

Plasma protein binding of catecholamines, prazosin and propranolol in diabetes mellitus

Trovik

Jaeger

Jorde

et al. 1992

Eur J Clin Pharmacol

Self Cite

View full text Add to dashboard Cite

show abstract

“…The standards and samples for catecholamine analyses were prepared [28] and the levels assayed with high performance liquid chromatography as described previously [29].…”

Section: Blood Samplesmentioning

confidence: 99%

Treatment with Growth Hormone and Insulin-Like Growth Factor-1 in Septicemia: Effects on Carbohydrate Metabolism

Balteskard¹,

Unneberg²,

Mjaaland³

et al. 1998

Eur Surg Res

Self Cite

View full text Add to dashboard Cite

Growth hormone (GH) and insulin-like growth factor-1 (IGF-1) may be beneficial against the protein catabolism seen in injury and septicemia. Further understanding of their effects on carbohydrate metabolism is needed. In a septic porcine model receiving total parenteral nutrition, pretreatment with GH or IGF-1 (or no treatment in controls) was followed by an infusion of live Escherichia coli bacteria. Endogenous glucose production, carbohydrate oxidation, glucose and lactate fluxes over the liver, gastrointestinal organs, kidney, and hindleg were determined. Endogenous glucose production increased during septicemia in the GH group. The metabolic acidosis induced by septicemia was augmented by GH, but attenuated by IGF-1. The alanine and lactate levels were significantly higher in the GH- than in the IGF-1-treated animals during septicemia. IGF-1 pretreatment appeared to induce favorable effects while GH pretreatment might produce unfavorable effects on carbohydrate metabolism in septic piglets.

show abstract

“…Blood with heparin (4 iu ml-1), reduced glutathione (4.5 nM) and EGTA (5 mM) was kept on ice before centrifugation at 1.000 g for 20 min at 40 C. The samples were stored at -20°C awaiting analysis. Standards and samples were prepared as described previously [7]. Plasma concentrations of catecholamines and isoprenaline were measured by h.p.l.c.…”

Section: Catecholamine and Isoprenaline Concentrationsmentioning

confidence: 99%

Reduced sensitivity to beta‐adrenoceptor stimulation and blockade in insulin dependent diabetic patients with hypoglycaemia unawareness.

Trovik

Jaeger

Jorde

et al. 1994

Brit J Clinical Pharma

View full text Add to dashboard Cite

with the dose of isoprenaline which increased heart rate by 25 beats min-'. 4 The dose/response curves of both isoprenaline/HR and metoprolol/HR were significantly shifted to the right in IDDM-patients with hypoglycaemia unawareness compared with controls and IDDM-patients with hypoglycaemia awareness (P < 0.05). 5 Reduced sensitivity of isoprenaline stimulation has also been shown before, whereas reduced sensitivity of a blocking agent has not earlier been shown. 6 These findings support the hypothesis of reduced ,-adrenergic sensitivity as one pathophysiological component in hypoglycaemia unawareness.

show abstract

Catecholamine binding and concentrations in acute phase plasma after surgery

Cited by 25 publications

References 18 publications

Plasma protein binding of catecholamines, prazosin and propranolol in diabetes mellitus

Plasma protein binding of catecholamines, prazosin and propranolol in diabetes mellitus

Treatment with Growth Hormone and Insulin-Like Growth Factor-1 in Septicemia: Effects on Carbohydrate Metabolism

Reduced sensitivity to beta‐adrenoceptor stimulation and blockade in insulin dependent diabetic patients with hypoglycaemia unawareness.

Contact Info

Product

Resources

About