2021
DOI: 10.1007/s12010-021-03511-1
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Catechin as the Most Efficient Bioactive Compound from Azadirachta indica with Antibiofilm and Anti-quorum Sensing Activities Against Dental Biofilm: an In Vitro and In Silico Study

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Cited by 48 publications
(27 citation statements)
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“…In this research, it was possible to observe an inhibition of total growth from the first incubation time (30 min) using SeNPs ( Figure 8 a,b). It could be due to the content of bioactive compounds in the Cof-Met extracts present on the surface of the SeNPs, capable of damaging the signaling receptors necessary to carry out quorum sensing (QS) [ 50 ], a chemical process of cell-to-cell communication used by bacteria such as A. faecalis to regulate their virulence and the formation of biofilms [ 51 , 52 ]. This QS inhibition has been reported using SeNPs biosynthesized with AsAc, with the average size of 85 nm, where the inhibition of the biosynthesis of crucial QS compounds such as violacein (80%) was demonstrated, suggesting the disruption of the QS signal [ 53 ].…”
Section: Resultsmentioning
confidence: 99%
“…In this research, it was possible to observe an inhibition of total growth from the first incubation time (30 min) using SeNPs ( Figure 8 a,b). It could be due to the content of bioactive compounds in the Cof-Met extracts present on the surface of the SeNPs, capable of damaging the signaling receptors necessary to carry out quorum sensing (QS) [ 50 ], a chemical process of cell-to-cell communication used by bacteria such as A. faecalis to regulate their virulence and the formation of biofilms [ 51 , 52 ]. This QS inhibition has been reported using SeNPs biosynthesized with AsAc, with the average size of 85 nm, where the inhibition of the biosynthesis of crucial QS compounds such as violacein (80%) was demonstrated, suggesting the disruption of the QS signal [ 53 ].…”
Section: Resultsmentioning
confidence: 99%
“…Neem contains highly water-soluble phytochemicals (flavonoids, tannins, polyphenols, catechins, gallic acid, quercetins, and saponins) with more health-promoting and biological effects [ 82 ]. It is anticipated that neem leaf extract targeted at sites other than those used by antibiotics will be effective against drug-resistant pathogens [ 83 ].…”
Section: Discussionmentioning
confidence: 99%
“…It was determined that catechin (flavan‐3‐ol) isolated from Azadirachta indica has strong antibiofilm effect on the dental plaque caused by P. gingivalis and Alcaligenes faecalis in vitro , catechin was further docked with quorum sensing LuxS protein (PDB ID: 6SLI) which also showed considerable interaction (Lahiri et al . 2021). In another study, both of in vitro and in silico studies were done to prove the anti‐quorum sensing potential of Senegalia nigrescens by selected phytochemicals and suggested that the S. nigrescens extracts and phytochemicals such as melanoxetin and quercetin‐3‐ O ‐methyl ether, have ability to reduce virulence and pathogenicity of drug‐resistant bacteria in vivo (Bodede et al .…”
Section: Resultsmentioning
confidence: 99%