Catarata diabética juvenil: Un hallazgo infrecuente que permitió el diagnóstico de esta enfermedad

Vila, P Orts; Torregrosa, P Devesa; Martínez, José Belmonte

doi:10.4321/s0365-66912003000700008

Cited by 2 publications

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“…In humans, unilateral and reversible diabetic cataracts were speculated to be associated with asymmetric subcapsular changes, and, accordingly, different damage of the lens fibers may be responsible for variable glucose permeability of the lenses [31]. As in young human patients, this finding might also indicate an early sign of DM in GPs [32]. The less pronounced lenticular changes in the contralateral eye of GP1 were easily missed without a detailed slit-lamp examination.…”

Section: Discussionmentioning

confidence: 99%

Successful Insulin Glargine Treatment in Two Pet Guinea Pigs with Suspected Type 1 Diabetes Mellitus

Kreilmeier-Berger

Zeugswetter

Blohm

et al. 2021

Animals

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Scientific information on spontaneous type I diabetes mellitus (DM) and treatment modalities in guinea pigs is scarce. As most diabetic guinea pigs are overweight and respond to dietary changes, a disorder resembling type II-DM in humans seems to be most prevalent in this species. In the present report, a nine-month-old female intact guinea pig (GP1) was presented because of a cataract and polyphagia. The physical examinations in GP1 and its littermate, GP2, were unremarkable. Laboratory tests revealed hyperglycemia, hyperlipidemia, elevated fructosamine concentrations, and glucosuria in GP1 and GP2. Not responding to dietary changes, an insulin-dependent diabetes mellitus was suspected in both animals. Treatment with 0.5 IU of glargine insulin (Lantus®) per guinea pig subcutaneously (s.c.) once daily was initiated in both animals. Monitoring included repeated clinical evaluations and the measurement of plasma glucose and fructosamine concentrations. Capillary glucose concentration was measured using a glucometer, and glucosuria was monitored by dipstick. Blood glucose concentrations decreased quickly in both GPs, and glucosuria resolved. Including several dose adjustments, DM remained controlled for over 1.5 years. Bilateral cataracts and lens-induced uveitis in GP1 were medically managed with only slight progression. This is the first report of guinea pigs with insulin-dependent diabetes mellitus that were successfully treated with long-acting basal insulin glargine.

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Section: Discussionmentioning

confidence: 99%

Successful Insulin Glargine Treatment in Two Pet Guinea Pigs with Suspected Type 1 Diabetes Mellitus

Kreilmeier-Berger

Zeugswetter

Blohm

et al. 2021

Animals

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Prevalence and risk factors for myopia in Taiwanese diabetes mellitus patients: a multicenter case–control study in Taiwan

Lin

Zheng

Fang

et al. 2021

Sci Rep

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This population-based retrospective cohort study investigated the prevalence of myopia among patients with Type 1 and Type 2 diabetes mellitus (DM) and evaluate risk factors for myopia in these groups. Records from 2000 to 2012 with at least one year of follow-up from the Taiwan National Health Insurance Research Database were included. This study included 35,538 patients with DM and 71,076 patients without DM. Patients with DM had a significantly higher adjusted hazard ratio for myopia in all age groups and both sexes compared with patients without DM. The subgroup analysis results revealed that the rates of myopia and astigmatism were significantly higher among patients with DM compared with patients without DM aged < 60 years. However, the rates of high myopia or myopia progression to high myopia did not differ significantly between the two groups. These findings indicate that DM is a critical risk factor for myopia and astigmatism among patients aged < 60 years. Therefore, active surveillance and earlier treatment of myopia are critical for patients with DM.

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Catarata diabética juvenil: Un hallazgo infrecuente que permitió el diagnóstico de esta enfermedad

Cited by 2 publications

References 0 publications

Successful Insulin Glargine Treatment in Two Pet Guinea Pigs with Suspected Type 1 Diabetes Mellitus

Successful Insulin Glargine Treatment in Two Pet Guinea Pigs with Suspected Type 1 Diabetes Mellitus

Prevalence and risk factors for myopia in Taiwanese diabetes mellitus patients: a multicenter case–control study in Taiwan

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