Catanionic lipid nanosystems improve pharmacokinetics and anti-lung cancer activity of curcumin

Li, Songlin; Fang, Chunshu; Zhang, Jingqing; Liu, Bilin; Wei, Zhuanqin; Fan, Xiaoxi; Sui, Zheng; Tan, Qunyou

doi:10.1016/j.nano.2016.02.007

Cited by 45 publications

(23 citation statements)

References 49 publications

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“…Furthermore, the effective methods are researching and developing to improve the anti-cancer activity of natural agents, such as curcumin. Researchers try to enhance anti-lung cancer activity of curcumin via catanionic lipid nanosystems [8]. Several reports have demonstrated that osthole inhibited cell growth and proliferation by inducing apoptosis, cell cycle arrest, and inhibition of migration and invasion in various types of tumors, such as glioma, colorectal cancer, and lung cancer [14,30,31,32].…”

Section: Discussionmentioning

confidence: 99%

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Osthole Induces Cell Cycle Arrest and Inhibits Migration and Invasion via PTEN/Akt Pathways in Osteosarcoma

Wang

Lei

et al. 2016

Cell Physiol Biochem

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Background/Aims: Osteosarcoma is the second highest cause of cancer-related death in children and adolescents. Majority of osteosarcoma patients (90%) show metastasis. Previous reports revealed that osthole showed antitumor activities via induction of apoptosis and inhibition of proliferation. However, the potential effects and detailed molecular mechanisms involved remained unclear. Methods: Cell viability was analyzed by MTT assay in osteosarcoma cell lines MG-63 and SAOS-2. Cell cycle was detected by flow cytometry. The effects of migration and invasion were evaluated by wound healing assay and transwell assays. Moreover, the level of proteins expression was determined by Western blot. Results: The cell viability of MG63 and SAOS-2 were markedly inhibited by osthole in a dose- and time-dependent manner. Cell cycle was arrested and the ability of migration and invasion was obviously reduced when cells were exposed to osthole. Moreover, enzymes involved in PTEN/Akt pathway were regulated such as PTEN and p-Akt proteins. Furthermore, osthole inhibited the tumor growth in vivo. Conclusion: Our study unraveled, for the first time, the ability of osthole to suppress osteosarcoma and elucidated the regulation of PTEN/Akt pathway as a signaling mechanism for the anti-tumor action of osthole. These findings indicate that osthole may represent a novel therapeutic strategy in the treatment of osteosarcoma.

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Section: Discussionmentioning

confidence: 99%

“…Such as, allicin suppresses pancreatic cancer cell via apoptotic pathway, and curcumin plays a crucial role in anti-lung cancer activity. Moreover, it is reported that formononetin plays an important function on anti-cancer activity against osteosarcoma [7,8,9]. Osthole is one of effective monomers found in Cnidium monnieri .…”

Section: Introductionmentioning

confidence: 99%

Osthole Induces Cell Cycle Arrest and Inhibits Migration and Invasion via PTEN/Akt Pathways in Osteosarcoma

Wang

Lei

et al. 2016

Cell Physiol Biochem

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“…1 It is reported that CM possesses multiple biomedical functions, such as antibacterial, antioxidant, anticancer, anti-inflammatory, anticarcinogenic, antispasmodic, and anticoagulant properties. [2][3][4] Importantly, oral administration of CM 12 g/day exhibited little toxicity in clinical trials. 5 However, clinical applications of insoluble CM face more challenging issues, such as low dissolution rate, low bioavailability, and controlled delivery.…”

Section: Introductionmentioning

confidence: 99%

Supercritical carbon dioxide-developed silk fibroin nanoplatform for smart colon cancer therapy

Xie¹,

Fan²,

Li³

et al. 2017

IJN

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Purpose To deliver insoluble natural compounds into colon cancer cells in a controlled fashion. Materials and methods Curcumin (CM)–silk fibroin (SF) nanoparticles (NPs) were prepared by solution-enhanced dispersion by supercritical CO 2 (SEDS) (20 MPa pressure, 1:2 CM:SF ratio, 1% concentration), and their physicochemical properties, intracellular uptake efficiency, in vitro anticancer effect, toxicity, and mechanisms were evaluated and analyzed. Results CM-SF NPs (<100 nm) with controllable particle size were prepared by SEDS. CM-SF NPs had a time-dependent intracellular uptake ability, which led to an improved inhibition effect on colon cancer cells. Interestingly, the anticancer effect of CM-SF NPs was improved, while the side effect on normal human colon mucosal epithelial cells was reduced by a concentration of ~10 μg/mL. The anticancer mechanism involves cell-cycle arrest in the G 0 /G 1 and G 2 /M phases in association with inducing apoptotic cells. Conclusion The natural compound-loaded SF nanoplatform prepared by SEDS indicates promising colon cancer-therapy potential.

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“…The markedly enhanced bioavailability of EVONE might be partly ascribed to the increased absorption with a higher absorptive rate and more effective permeability than free EVO. EVO was a substrate of P-glycoprotein in the human hepatoma HepG2 cells [ 18 ], while EVONE might protect EVO from deactivation in the gastro-intestinal segments, by entrapping EVO inside the nanoemulsions containing the P-glycoprotein and cytochrome P450 inhibitory surfactants [ 43 ]. EVONE also might protect EVO from elimination in systemic circulation before it is released from the nanocarriers.…”

Section: Discussionmentioning

confidence: 99%

Efficient intracellular delivery makes cancer cells sensitive to nanoemulsive chemodrugs

et al. 2017

Self Cite

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Evodiamine has been documented to possess activities in numerous cancer cells. Our preliminary study showed that A549 cells were insensitive to evodiamine. In this paper, A549 cells are sensitive to nanoemulsive evodiamine (EVONE) through an efficient intracellular and systematic delivery. EVONE entered tumor cells by energy-dependent and mainly through clathrin-mediated endocytosis. EVONE exerted a higher cytotoxicity in a dose- and time-dependent manner. The enhanced induction of cell cycle arrest was ascribed to the down-regulation of cyclin B and cyclin dependent kinase 1, while the enhanced induction of apoptosis was due to the activation of caspase −3, −8 and −9 and the decreased B-cell lymphoma 2/ assaciated X protein ratio. Furthermore, the in vivo kinetic, bioavailability and in situ absorption characteristics of EVONE were much better than those of free evodiamine. The cancer cells insensitive to free chemodrugs became sensitive to nanoemulsive chemodrugs.

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Catanionic lipid nanosystems improve pharmacokinetics and anti-lung cancer activity of curcumin

Cited by 45 publications

References 49 publications

Osthole Induces Cell Cycle Arrest and Inhibits Migration and Invasion via PTEN/Akt Pathways in Osteosarcoma

Osthole Induces Cell Cycle Arrest and Inhibits Migration and Invasion via PTEN/Akt Pathways in Osteosarcoma

Supercritical carbon dioxide-developed silk fibroin nanoplatform for smart colon cancer therapy

Efficient intracellular delivery makes cancer cells sensitive to nanoemulsive chemodrugs

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