Catalytic Synthesis and Antifungal Activity of New Polychlorinated Natural Terpenes

Ighachane, Hana; Boualy, Brahim; Ali, Mustapha Ait; Sedra, M.H.; Firdoussi, Larbi El; Lazrek, H. B.

doi:10.1155/2017/2784303

Cited by 3 publications

(4 citation statements)

References 32 publications

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“…Full experimental detail, 1 H and 13 C NMR spectra, ESI Mass etc. This material can be found via the "Supplementary Content" section of this article's webpage.…”

Section: Acknowledgementsmentioning

confidence: 99%

“…[1][2][3][4][5][6][7] Among heterocyclic compounds quinazolines are well-recognized for their pharmacological properties, such as anticonvulsant [8], antihypertensive [9] and vasodilator [10]. The interest in the quinazolinic structure, due to its wide range of biological activities, [11][12][13][14][15][16][17][18][19] led to a many number of different synthetic pathways to access this quinazolines nucleus. Quinazolinone are divided into subcategories like 2-quinazolinone (a) and 4-quinazolinone (b) based on the substitution on quinazolinones shown in Figure 1.…”

Section: Introductionmentioning

confidence: 99%

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Novel oxo-5-(trifluoromethyl)quinazolinyl amide derivatives and their anticancer activity

Pandiri,

Konda,

Chennuri

et al. 2023

Preprint

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A series of novel oxo-5-(trifluoromethyl)quinazolinyl amide derivatives were prepared starting from 2-aminobenzoic acid 1, reacted with 4-Chlorobenzoyl chloride and obtained 2-(4-Chlorophenyl)-5-(trifluoromethyl)-4H-benzo[d][1, 3]oxazin-4-one 2, compound 2 on reaction with hydroxyl amine and obtained 2-(4-Chlorophenyl)-3-(4-hydroxyphenyl)-5-(trifluoromethyl)quinazolin-4(3H)-one 3, compound 3 on further react with bromoethyl acetate to get ethyl 2-(4-(2-(4-chlorophenyl)-4-oxo-5-(trifluoromethyl)quinazolin-3(4H)-yl) phenoxy) acetate 4, compound 4 on reaction with aliphatic and aryl amine to obtain amide functionalized quinazolinyl derivatives 5. All the final compounds evaluated for anti cancer activity against four human cancer cell lines such as ‘HeLa - Cervical cancer (CCL-2); COLO 205- Colon cancer (CCL-222); HepG2- Liver cancer (HB-8065); MCF7 - Breast cancer (HTB-22)’ and promising compounds 5l and 5m have been identified.

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“…Full experimental detail, 1 H and 13 C NMR spectra, ESI Mass etc. This material can be found via the "Supplementary Content" section of this article's webpage.…”

Section: Acknowledgementsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Novel oxo-5-(trifluoromethyl)quinazolinyl amide derivatives and their anticancer activity

Pandiri,

Konda,

Chennuri

et al. 2023

Preprint

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“…The therapeutic significance of terpenoids from different plants has been reported, e.g., terpenes from eucalyptus oil is known for its antidiabetic property [11], ursolic acid from Rosmarinus officinalis and β-sesquiphellandrene from Piper guineense are known to be psychoprotective [12]. Antibacterial and antifungal potential of terpenoids derived from Pilgerodendron uviferum, Picea abies and other plant sources have also been reported [13][14][15]. Furthermore, a steroidal terpenoids called glycyrrhizic acid elicited anti-inflammatory activity [8].…”

Section: Plant Secondary Metabolite and Their Therapeutic Significancementioning

confidence: 99%

Pharmacognosy: Importance and Drawbacks

Balogun¹,

Ashafa²,

Sabiu³

et al. 2019

Pharmacognosy - Medicinal Plants

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In many nations of the world, a great number of deaths and morbidity arising from illnesses are witnessed due to lack of basic health care. Phytotherapy has continued to play a significant role in the prevention and treatment of diseases (communicable and noncommunicable). Interestingly, more than 80% of the global populations now adopt phytotherapy as a basic source of maintaining good healthy conditions, owing to the pronounced side effects, nonavailability, and expensive nature of conventional treatment options. While this review looked at the prospects and downsides of phytomedicine as it relates to the national health care system, it established the fact that although a number of medicinal plants had been resourceful (effective) against a range of diseases, with few developed into drugs based on the available phytotherapeutics, quite a large number of them are yet to scale through clinical trials to determine their safety and efficacy. It is believed that until this is done, we hope phytomedicine to be adopted or integrated into the national health care system in many countries.

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“…The repeating isoprene units comprise several structures and functional groups that contribute to their wide range of biological activities . For example, some of these natural compounds have anti-inflammatory properties, , whereas others have antifungal, , antibacterial, antiviral, , and antitumor activities.…”

Section: Introductionmentioning

confidence: 99%

Terpenes and Terpenoids Conjugated with BODIPYs: An Overview of Biological and Chemical Properties

Stanková,

Jurášek,

Hajdúch

et al. 2024

J. Nat. Prod.

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Advancements in small-molecule research have created the need for sensitive techniques to accurately study biological processes in living systems. Fluorescent-labeled probes have become indispensable tools, particularly those that use boron−dipyrromethene (BODIPY) dyes. Terpenes and terpenoids are organic compounds found in nature that offer diverse biological activities, and BODIPY-based probes play a crucial role in studying these compounds. Monoterpene−BODIPY conjugates have exhibited potential for staining bacterial and fungal cells. Sesquiterpene−BODIPY derivatives have been used to study sarcoplasmic/endoplasmic reticulum calcium ATPase (SERCA), indicating their potential for drug development. Owing to their unique properties, diterpenes have been investigated using BODIPY conjugates to evaluate their mechanisms of action. Triterpene−BODIPY conjugates have been synthesized for biological studies, with different spacers affecting their cytotoxicity. Fluorescent probes, inspired by terpenoid-containing vitamins, have also been developed. Derivatives of tocopherol, coenzyme Q10, and vitamin K1 can provide insights into their oxidation−reduction abilities. All these probes have diverse applications, including the study of cell membranes to investigate immune responses and antioxidant properties. Further research in this field can help better understand and use terpenes and terpenoids in various biological contexts.

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Catalytic Synthesis and Antifungal Activity of New Polychlorinated Natural Terpenes

Cited by 3 publications

References 32 publications

Novel oxo-5-(trifluoromethyl)quinazolinyl amide derivatives and their anticancer activity

Novel oxo-5-(trifluoromethyl)quinazolinyl amide derivatives and their anticancer activity

Pharmacognosy: Importance and Drawbacks

Terpenes and Terpenoids Conjugated with BODIPYs: An Overview of Biological and Chemical Properties

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