Novel oxo-5-(trifluoromethyl)quinazolinyl amide derivatives and their anticancer activity

Abstract

A series of novel oxo-5-(trifluoromethyl)quinazolinyl amide derivatives were prepared starting from 2-aminobenzoic acid 1, reacted with 4-Chlorobenzoyl chloride and obtained 2-(4-Chlorophenyl)-5-(trifluoromethyl)-4H-benzo[d][1, 3]oxazin-4-one 2, compound 2 on reaction with hydroxyl amine and obtained 2-(4-Chlorophenyl)-3-(4-hydroxyphenyl)-5-(trifluoromethyl)quinazolin-4(3H)-one 3, compound 3 on further react with bromoethyl acetate to get ethyl 2-(4-(2-(4-chlorophenyl)-4-oxo-5-(trifluoromethyl)quinazolin-3(4H)-yl) phenoxy) acetate 4, compound 4 on reaction with aliphatic and aryl amine to obtain amide functionalized quinazolinyl derivatives 5. All the final compounds evaluated for anti cancer activity against four human cancer cell lines such as ‘HeLa - Cervical cancer (CCL-2); COLO 205- Colon cancer (CCL-222); HepG2- Liver cancer (HB-8065); MCF7 - Breast cancer (HTB-22)’ and promising compounds 5l and 5m have been identified.