Catalytic Reduction of Alpha-Diketones and Their Derivatives

Síntese da fenitoína assistida por micro-ondas: proposta de aula prática para alunos de graduação

“…A oxidação da benzoína à sua respectiva alfa-dicetona, a benzila, é um método relativamente simples e amplamente descrito na literatura com o uso de diversos agentes oxidantes, como ácido nítrico, 24 solução de Fehling, 25 nitrato de tálio (III), 26 acetato de nitrato-cobre (II) e bismuto (III), 27 sais de cromo com alumina ácida, 28 dentre outros. Mais recentemente, foi relatada uma reação de oxidação para a benzoína empregando-se hidreto de sódio, 29 resultando em um rendimento elevado e sem o emprego de reagentes tóxicos, numa busca por um processo sintético mais limpo e seguro do ponto de vista ambiental.…”

Green chemistry-mediated synthesis of benzil by using nano-MgO

“…[8] Benzil is extensively used as substrate in benzylic rearrangements and also acts as a starting material for the synthesis of many heterocyclic compounds [9,10] exhibiting biological activity such as anticonvulsant derivative dilantin. [11,12] The oxidation of benzoins is one of the most efficient and practical methods for the synthesis of benzils. In general, the oxidation of benzoins to benzils has been used, such as hallium nitrate, [13] ammonium nitrate-copper acetate, [14] bismuth nitrate-copper acetate, [15] and ferric nitrate.…”

An Efficient Oxidation of Benzoins to Benzils by Manganese(II) Schiff Base Complexes Using Green Oxidant

“…e oxidation of benzoins is one of the most efficient and practical methods for the synthesis of benzils. In general, the oxidation of benzoins to benzils has been accomplished by classical reagents such as nitric acid [4], Fehling's solution [4], thallium nitrate [5], ammonium nitrate-copper acetate [6], bismuth nitrate-copper acetate [7], and ferric nitrate [8]. In addition, the oxidation of benzoins to benzils was studied using p-benzoquinone or air in the presence of (Fe II (SPh) 4 ) 2 and (Fe II (SePh) 4 ) 2 [9], Fe(II)-cysteine peptide complexes [7] and ter.…”