Catalytic processes in vitamins synthesis and production

Hydrogenation in the Vitamins and Fine Chemicals Industry – An Overview

“…In the pharmaceutical and partly also in the fine chemicals industry many chemical conversions require stoichiometric amounts of reagents, and thus generate large amounts of waste [1,2]. This is in contrast to the production of bulk chemicals which mostly relies on catalysis.…”

“…14. The C3-elongation can be carried out by Saucy-Marbet or Carroll reactions and the C2 elongation by ethynylation or vinylation reactions (vinyl Grignard addition) [1]. In such reaction sequences several hydrogenations of C=C bonds are necessary.…”

Drug Design by Regression Analyses of Newly Synthesized Derivatives of 8-Quinolinol

“…Furthermore, the compounds with proven antibacterial activity and concentration 1x10 -4 % were used for preparation of solutions with concentrations 1x10 -5 %, 1x10 -6 % and 1x10 -7 %. Filter paper discs "Vatman-3" with 5.5 mm diameter were sterilized for 1.5-2 min at temperature 160 0 C. Afterwards, 0.01 cm 3 of the corresponding solutions were absorbed on each of the discs. They were placed on the surface of the culture medium that was preliminary inoculated with broth culture of the corresponding pathogen.…”

“…Twenty four compounds that exhibited a relatively high antibacterial activity in the preliminary microbiological screening were used: esters ( 3 (with solvent dimethylformamide). Activated broth cultures from the used microbial species were applied to the agar surface and cultivated at 37 0 C for 24 h. MIC was accepted as the lowest concentration of the test compound, for which complete inhibition of microbial growth was established.…”

“…To accomplish this purpose, the minimal inhibitory concentrations (MIC, mg/dm 3 ) of the investigated compounds against Staphylococcus aureus were determined and applied for the mathematical model.…”