Catalytic prenylation of natural polyphenols

Abstract

Prenylated polyphenols occur naturally and exhibit biological activity superior to the ubiquitous parent polyphenols. However, their low abundance limits the broader application of these derivatives. This work presents an expedient,...

Heterologous biosynthesis of prenylated resveratrol through multiplex metabolic engineering in Escherichia coli

“…Prenylation represents a prevalent chemical modification capable of adjusting the polarity, lipophilicity, and biological functionalities of polyphenols, thereby enhancing their bioavailability. 14 Prenylated derivatives have been discerned within various polyphenol subclasses, encompassing chalcones, stilbenes, flavanones, flavones, flavonols, and isoflavones.…”

“…10,11 It has been established that introducing a prenyl group into the ring system of stilbenoids can enhance their lipophilicity and increase their affinity to biological membranes, thereby improving their cellular accessibility. 12–14 However, the limited availability of prenylated stilbenoids and their complex composition in plants result in high extraction costs and low yields. This hampers further exploration of their potential applications for human health benefits.…”