Catalytic Oxidation of Alcohols and Amines to Value‐Added Chemicals using Water as the Solvent

Abstract

Designing reactions in aqueous media has been one of the major challenges in modern organic synthesis, especially to avoid the use of large amounts of organic solvents whose disposal is a matter of grave concern from an environmental perspective. The oxidation of alcohols and amines is an essential and important step in the synthesis of many valuable products including polymers and pharmaceuticals. In recent times, there has been a surge in the use of water as a solvent in many organic reactions. This review focuses specifically on the oxidation reactions of alcohols and amines carried out in water media using transition metal catalysts, metal‐free catalysts and photocatalysts.

Visible Light-Induced Aerobic Oxidative Dehydrogenation of C–N/C–O to C=N/C=O Bonds Using Metal-Free Photocatalysts: Recent Developments

“…The oxidation of organic compounds is one of the most performed transformations in organic synthesis, since it is extensively used in the industry to synthesize drugs and fine chemicals [55,56]. Traditional oxidation methodologies use stoichiometric amounts of manganese-, chromium-or hypervalent halogen-based oxidants, which are toxic, have low selectivities, are expensive and generate undesired waste, as well as catalysts based on noble metals.…”

Reactivity of Styrenes in Micelles: Safe, Selective, and Sustainable Functionalization with Azides and Carboxylic Acids

“…Besides its obvious natural abundance, water is usually considered among the safest reaction solvents. It has been efficiently employed in “on water” and “in water” chemistry for many diverse transformations. − Aqueous micellar catalysis, a major enabler of chemistry in water, has recently gained attraction due to its applications to 4S reaction methodologies. − Many important transformations have been shown to occur in micellar media. − Our group has recently designed an amphiphile PS-750-M that structurally mimics the dipolar-aprotic solvent that enables several transformations which traditionally require DMF, DMAc, NMP, and 1,4-dioxane. − Additionally, the design hypothesis of PS-750-M assisted in gaining insight into how micellar nano-organometallic chemistry occurs. To date, preliminary answers to some fundamental questions are now in hand, such as, where and how chemistry occurs in micellar media and how reaction intermediates (radical, carbene, carbanion) react under the shielding effect of micelles.…”

Bio‐derived nanosilica‐anchored Cu(II)‐organoselenium complex as an efficient retrievable catalyst for alcohol oxidation

“…Substrate scope for aliphatic alcohols using water‐based catalytic systems still poses a major challenge due to poor water solubility of the substrates. [ 7 ] A triphasic system (solid–liquid–liquid) without co‐solvent over microporous titanium silicate showed enhanced catalytic activity and para selectivity in the oxidation of benzyl alcohol, cyclohexanol, etc. compared with biphasic (solid–liquid) systems.…”

“…[1,2] Till date, numerous methodologies are available to affect this transformation. [3][4][5][6][7] Traditionally, for the oxidation of alcohols to produce corresponding aldehydes/ketones, transition metals such as Cr(VI) and Mn(II) were widely used, which are toxic, corrosive and expensive. [8][9][10][11] Moreover, several reports are available, which used Cr-, Mn-, Fe-, Cu-, Mo-, Ru-, Pt-, Pd-, Mn-and Os-based catalyst in the presence of oxidants, such as molecular oxygen, tertiary butyl hydroxide (TBHP), hydrogen peroxide and sodium hypochlorite with toxic and costly solvents.…”